A research team led by CU SRP PI Habibul Ahsan and Brandon Pierce, University of Chicago Medicine, with contributions by SRP scientists Marie Argos, Joseph Graziano, Mary Gamble, Faruque Parvez, and Vesna Slavkovich has discovered genetic variants that elevate the risk for skin lesions in people chronically exposed to arsenic, as part of the first large-scale genomic studies in a developing country. Genetic changes found near the enzyme for metabolizing the chemical into a less toxic form can significantly increase an individual's risk for developing arsenic-related disease (summary link below).
Pierce BL, Kibriya MG, Tong L, Jasmine F, Argos M, et al. (2012) Genome-Wide Association Study Identifies Chromosome 10q24.32 Variants Associated with Arsenic Metabolism and Toxicity Phenotypes in Bangladesh. PLoS Genet 8(2): e1002522. doi:10.1371/journal.pgen.1002522