Archived Announcements

May 1 2012

IRIS Inputs Requested

The EPA Integrated Risk Information System (IRIS) released its list of chemicals that have been selected for inclusion in its 2012 agenda. EPA is requesting information from the public for consideration in the development of these assessments. Two of the chemicals that may be of interest to SRP researchers are manganese and mercury. If you have publications that may be related to a risk assessment of either of these chemicals, you are encouraged to submit them at www.regulations.gov.

Related link(s):
Announcement type: CU SRP Announcements

February 23 2012

Variants Associated with Arsenic Metabolism and Toxicity Phenotypes in Bangladesh

A research team led by CU SRP PI Habibul Ahsan and Brandon Pierce, University of Chicago Medicine, with contributions by SRP scientists Marie Argos, Joseph Graziano, Mary Gamble, Faruque Parvez, and Vesna Slavkovich has discovered genetic variants that elevate the risk for skin lesions in people chronically exposed to arsenic, as part of the first large-scale genomic studies in a developing country. Genetic changes found near the enzyme for metabolizing the chemical into a less toxic form can significantly increase an individual's risk for developing arsenic-related disease (summary link below).

Citation:

Pierce BL, Kibriya MG, Tong L, Jasmine F, Argos M, et al. (2012) Genome-Wide Association Study Identifies Chromosome 10q24.32 Variants Associated with Arsenic Metabolism and Toxicity Phenotypes in Bangladesh. PLoS Genet 8(2): e1002522. doi:10.1371/journal.pgen.1002522
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Announcement type: CU SRP Publications

October 1 2011

Manganese Exposure from Drinking Water and Children’s Classroom Behavior in Bangladesh

As part of the SRP child development project in Araihazar, Bangladesh, this cross-sectional study investigates the associations of manganese and arsenic in tube well water with classroom behavior among more than 200 elementary school children, 8–11 years of age.  The study examines specificity in the exposure/behavior problems by assessing both exter­nalizing and internalizing behavior. Its findings reinforce the growing concern regarding neurotoxicologic effects for children exposed to high manganese levels in drinking water.

Citation:

Khalid Khan, Pam Factor-Litvak, Gail A. Wasserman, Xinhua Liu, Ershad Ahmed, Faruque Parvez, Vesna Slavkovich, Diane Levy, Jacob Mey, Alexander van Geen, and Joseph H. Graziano. Manganese Exposure from Drinking Water and Children’s Classroom Behavior in Bangladesh. Enviromental Health Perspectives. Oct 2011; 119(10):1501-1506.

Announcement type: CU SRP Publications

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