Archived Announcements

March 5 2014

Additional evidence that nutritional status may explain differences in susceptibility to arsenic toxicity

Caitlin Howe, Columbia SRP student with Project 3, is the lead author of the upcoming paper, "Folate and Cobalamin Modify Associations between S-adenosylmethionine and Methylated Arsenic Metabolites in Arsenic-Exposed Bangladeshi Adults" that will appear in the May 2014 publication of the Journal of Nutrition. Co-authors include Columbia SRP student alumnae and scientists as well as collaborators from Columbia University Arsenic Project in Bangladesh. The key findings provide additional evidence that nutritional status may explain some differences among individuals in arsenic metabolism and, thus, susceptibility to arsenic toxicity. The paper is currently available online. Please see the link below.

Suggested citation:

Howe CG, Niedzwiecki MM, Hall MN, Liu X, Ilievski V, Slavkovich V, Alam S, Siddique AB, Graziano JH,4 and Gamble MV. Folate and Cobalamin Modify Associations between S-adenosylmethionine and Methylated Arsenic Metabolites in Arsenic-Exposed Bangladeshi Adults J. Nutr. May 2014 jn.113.188789; first published online March 5, 2014. doi:10.3945/jn.113.188789.

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Announcement type: CU SRP Publications

March 3 2014 to March 4 2014

NIEHS Health Effects & Mitigation of Arsenic Workshop

The NIEHS Health Effects & Mitigation of Arsenic: Current Research Efforts and Future Directions workshop will highlight significant new and emerging research on lowdose exposure to arsenic in human health (cancer and non-cancer) such as environmental and endogenous bioavailability associated with arsenic toxicity, susceptibility to arsenic's health effects, advanced techniques to understand arsenic in health and environment, and current mitigation/remediation efforts of arsenic in the US and globally. Speakers and participants will represent a range of scientific expertise (e.g., epidemiology, human and animal toxicology, exposure, chemistry, microbiology, detection, and mitigation/remediation) and will consist of scientists from academia, federal/state/local agencies, and other researchers with an interest in this field of study. On Day 2, Dr. Maria Argos, Project 1 scientist with the Columbia SRP, will participate in a panel discussion on Contributions of Advanced Techniques to Understanding Arsenic in Health and Environment. Later that day, Drs. Megan Hall and Alexander van Geen will present papers as part of the session on Prevention and Remediation Strategies for Arsenic Exposure. They are then joined with Dr. Mary Gamble for a panel discussion on that topic. In addition, the workshop will include a poster session for sharing additional information on ongoing research.

The product from the workshop will be a report/white paper/publication consisting of summaries from each of the speakers discussing knowledge gaps in their particular area of research and their vision for the future of arsenic research. In addition, the report will provide the current state of the science in arsenic research and a summary of additional knowledge gaps that arose from the workshop. Importantly, using the recommendations provided by this workshop, the report will outline suggested topic areas on which to focus upon for future arsenic research efforts.

For more information on the workshop, please see the NIEHS workshop website below.


Sponsored by: NIEHS
Location: NIEHS Main Campus, Rall Building, Rodbell A, B, C
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Announcement type: General Announcements

October 15 2013 to October 17 2013

Superfund Research Program 2013 Annual Meeting

The SRP Annual Meeting this fall was hosted by LSU in Baton Rouge, Louisiana from Oct 15-17th. The scientific session focused on Arsenic and Metals.

Meeting Dates:

October 15-17, 2013, Baton Rouge, Louisiana

Tuesday, October 15: Research Translation and Community Engagement Cores (all day); R01 grantees (afternoon), and trainees (afternoon), opening reception

Wednesday, October 16 and Thursday, October 17: Plenary sessions, scientific meeting, administrator meeting

For More Information

Please see the conference website:  If you have any questions about the scientific sessions, please contact Dr. Tammy Dugas (TDugas [at]

Sponsored by: LSU SRP
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Announcement type: General Announcements

September 11 2013

Nature publication: Retardation of arsenic transport through a Pleistocene aquifer

Benjamin Bostick and Nguyen-Ngoc Mai at a high-arsenic well near village of Van Phuc (credit: Charles Harvey, MIT)

Nature published on September 11, 2013 a paper by CU SRP scientists Alexander van Geen, Benjamin Bostik, Kathleen Radloff, Zahid Aziz, Jacob L. Mey along with several of their collaborators on "Retardation of arsenic transport through a Pleistocene aquifer". Here they present findings from their study on the contamination of a Pleistocene aquifer near Hanoi, Vietnam. Their study reveals that "changes in groundwater flow conditions and the redox state of the aquifer sands induced by groundwater pumping caused the lateral intrusion of arsenic contamination more than 120 metres from a Holocene aquifer into a previously uncontaminated Pleistocene aquifer.We also find that arsenic adsorbs onto the aquifer sands and that there is a 16–20-fold retardation in the extent of the contamination relative to the reconstructed lateral movement of groundwater over the same period. Our findings suggest that arsenic contamination of Pleistocene aquifers in south and southeast Asia as a consequence of increasing levels of groundwater pumping may have been delayed by the retardation of arsenic transport."

The research presented here was fund by the US National Science Foundation and the NIEHS Superfund Research Program.

Additional authors include Vi Mai Lan, Nguyen-Ngoc Mai, Phu Dao Manh and Pham Hung Viet, of the Hanoi University of Science, Mason Stahl and Charles Harvey from MIT, Beth Weinman from Vanderbilt University along with researchers from Anchor QEA, Eawag Swiss Federal Institute of Aquatic Science and Technology,Institute of Geochemistry and Petrology, Swiss Federal Institute of Technology.

Suggested citation:
van Geen, A., Bostick, B., Thi Kim Trang, P., et al. 2013. Retardation of arsenic transport through a Pleistocene aquifer. Nature 501, 204–207 doi:10.1038/nature12444 (onine 12 September 2013).

Sponsored by: NIEHS Superfund Research Program and National Science Foundation
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Announcement type: CU SRP Publications

July 30 2013 to August 1 2013

EPA Community Involvement Training Conference

The EPA Office of Water, EPA Region 1, and the EPA Office of Solid Waste and Emergency Response are hosting the U.S. Environmental Protection Agency's (EPA) 13th Community Involvement Training Conference which will be held at the Westin Boston Waterfront Hotel Boston, Massachusetts July 30-August 1, 2013. The goal of this conference is both inform and train EPA staff, Agency stakeholders, and partners who plan and implement environmental community involvement and public communication, education and stewardship programs.

Registration for attending in person the EPA Community Involvement Training Conference is now open (see below for link) and will close on July 17th. Registration for online streaming sessions of the conference will be available later in June.

Location: Boston, Massachusetts
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Announcement type: General Announcements

July 29 2013 to July 31 2013

Environmental Health Disparities & Environmental Justice Meeting

On July 29-31, 2013 the National Institute of Environmental Health Sciences (NIEHS) in partnership with U.S. Environmental Protection Agency (EPA) , National Institute on Minority Health and Health Disparities (NIMHD) , Centers for Disease Control and Prevention (CDC) , Office of Minority Health (OMH) , Indian Health Service (IHS) will host a meeting focused on identifying priorities for action to address environmental health disparities (EHD) and environmental justice (EJ). This meeting will take place at the NIEHS Campus at Research Triangle Park in North Carolina. The deadline for submitting poster abstracts is July 5th and for hotel reservations, July 7th. Online meeting registration is now closed. Please contact Whitney Freberg at 919-794-4700 or "whitney. freberg at" to secure a place on the waiting list for this meeting.

The meeting will bring together researchers, community residents, healthcare professionals, and federal partners committed to addressing EHD and EJ, in particular the grantees funded by NIEHS, EPA, NIMHD, CDC, OMH, and IHS. For the purposes of this meeting, EHD is defined as the unique contribution of the environment to health disparities.

The main goals of this meeting will be to:

  1. Acknowledge and build off past meetings that have identified historical EHD & EJ issues
  2. Prioritize research areas to ensure the most vulnerable populations' issues are addressed
  3. Identify emerging EHD or EJ issues (new exposures that have not been considered in the past that may lead to new or additional health disparities) and,
  4. Develop a set of priorities that enables participants to set multi-year plans to address the most critical EHD and EJ issues

The meeting will include presentations, small group discussions, demonstrations, and poster sessions that lead to the development of an action agenda. Presenters will highlight challenges, emerging opportunities, and strategies to build upon existing efforts that bring community groups together with researchers. Specifically, the meeting will highlight and promote best practices of current and past EHD and EJ projects, and identify emerging issues and new directions in research, communication, capacity building, training, and evaluation. An additional goal of the meeting will be to foster new partnerships at the local, state, regional, tribal, and national levels. The meeting is also intended to bring together new partners to the discussion of environmental health disparities. Such partners could include: anthropologists, sociologists, and economists as well as those with expertise in law, policy, analysis and evaluation.

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Announcement type: General Announcements

July 1 2013

NIEHS SRP 16th Annual Wetterhahn Award

The SRP has established Annual Wetterhahn Award to recognize an outstanding graduate student or post-doctoral researcher that best demonstrates the qualities of scientific excellence exhibited by Dr. Karen Wetterhahn, who served as the Program Director of the Dartmouth College SRP from 1995 until she died in 1997. She was a leader in conducting research on how metals initiate cancer and other metal-induced human diseases at the molecular level. Dr. Wetterhahn passed awayas a result of dimethylmercury poisoning caused by the accidental spill of a few drops of the chemical on her latex glove-covered hand.

The award is open to ALL SRP trainees to apply (an SRP trainee is either funded directly by an SRP grant (P42 or R01) or is conducting research or other activities funded by SRP). SRP Center Directors, Project Leaders, and Core Leaders can nominate students and researchers.

Applications will be accepted between July 1st and August 1st. Please see links below for the Wetterhahn web page and application guidelines.

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Announcement type: General Announcements

July 1 2013

Blood glutathione redox status and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults

The July issue of Epigenetics will include a paper by Mailman graduate student Megan Niedzwiecki and her Columbia SRP colleagues entitled “Blood glutathione redox status and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults”. In this article, the researchers investigated the relationship between oxidative stress and DNA methylation in humans.   Oxidative stress and DNA methylation are metabolically linked:  depletion of glutathione (GSH), the body’s primary antioxidant, might lead to depletion of S-adenosylmethionine (SAM), the universal methyl donor for methylation reactions.  Additionally, many enzymes involved in DNA methylation show altered activity under oxidized cellular conditions., The Columbia SRP scientists tested the hypothesis that a more oxidized blood GSH redox status is associated with decreased global peripheral blood mononuclear cell (PBMC) DNA methylation in a sample of Bangladeshi adults. They found that a more oxidized blood GSH redox state was associated with decreased global DNA methylation, but blood SAM was not a mediator of this association. Future research should explore mechanisms through which cellular redox status might influence global DNA methylation as this may represent an important pathway leading towards both carcinogenic and non-carcinogenic mechanisms of action of arsenic. Given that redox status and DNA methylation are both potentially modifiable through nutritional and other interventions, a greater mechanistic understanding of these observations could ultimately have therapeutic implications.

Suggested citation:

Niedzwiecki M, Hall MN, Liu X, Oka J, Harper KN, Slavkovich V, Ilievski V, Levy D, van Geen A, Mey JL, Alam S, Siddique AB, Parvez F, Graziano JH, and Gamble MV. Blood glutathione redox status and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults. Epigenetics 2013:8(7):730-738. Published Online: May 17, 2013.

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Announcement type: CU SRP Publications

June 21 2013

EHP Publication: Chronic Arsenic Exposure and Blood Glutathione and Glutathione Disulfide Concentrations in Bangladeshi Adults

Exposure to arsenic (As) has been shown to deplete glutathione (GSH), the primary intracellular antioxidant, and induce oxidative stress in In vitro and rodent studies. Glutathione disulfide (GSSG) is produced after GSH donates an electron to reactive oxygen species.  The primary objective of this study was to test whether As exposure was associated with decreases in GSH and increases in GSSG, i.e., a more oxidized intracellular environment. Lead author Dr. Hall and her colleagues also investigated whether As exposure was associated with reductions in cysteine (Cys) and increases in cystine (CySS); Cys and CySS are the predominant thiol/disulfide redox couple found in human plasma.  The authors observed inverse associations of As exposure with GSH and Cyss, but no associations with GSSG and Cys and concluded that “The observed associations are consistent with the hypothesis that As may influence concentrations of GSH and other non-protein sulfhydryls through binding and irreversible loss in bile and/or possibly in urine.”

Hall MN, Niedzwiecki M, Liu X, Harper KN, Alam S, Slavkovich V, Ilievski V, Levy D, Siddique S, Parvez F, Mey JL, van Geen A, Graziano J, and Gamble MV. Chronic Arsenic Exposure and Blood Glutathione and Glutathione Disulfide Concentrations in Bangladeshi Adults. Environmental Health Perspectives Advance Publication: 21 June 2013.

Announcement type: CU SRP Publications

June 10 2013

Two Potential Perils in Cancer Studies Involving DNA Methylation Array Analysis

The June publication of Cancer Epidemiology Biomarkers & Prevention features a paper by Kristin Harper, Bradilyn Peters, and Mary Gamble on “Batch Effects and pathway analysis: Two potential perils in cancer studies involving DNA methylation array analysis”. It includes some recent findings from their research under the Columbia Superfund Research Program’s Project 3, Impact of Nutrition on Arsenic-Induced Epigenetic Dysregulation.

DNA methylation microarrays have become an increasingly popular means of studying the role of epigenetics in cancer, although the methods used to analyze these arrays are still being developed and existing methods are not always widely disseminated among microarray users.

Harper, Peters, and Gamble investigated two problems likely to confront DNA methylation microarray users: (i) batch effects and (ii) the use of widely available pathway analysis software to analyze results. First, DNA taken from individuals exposed to low and high levels of drinking water arsenic were plated twice on Illumina's Infinium 450 K HumanMethylation Array, once in order of exposure and again following randomization. Second, they conducted simulations in which random CpG sites were drawn from the 450 K array and subjected to pathway analysis using Ingenuity's IPA software.

They concluded that the analyses illustrated the pitfalls of not properly controlling for chip-specific batch effects as well as using pathway analysis software created for gene expression arrays to analyze DNA methylation array data. The in silico pathway analysis experiment yielded spurious but significant findings due to over-representation of CpGs on the 450K array chip that were associated with genes involved in pathways linked to cancer, developmental disorders, cellular development, cell morphology, embryological development, and more.

Suggested citation

Harper KN, Peters BA, Gamble MV. Batch Effects and pathway analysis: Two potential perils in cancer studies involving DNA methylation array analysis. Cancer Epidemiol Biomarkers Prev 2013; 22(6); 1–9. Published OnlineFirst April 29, 2013; doi:10.1158/1055-9965.EPI-13-0114.

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Announcement type: CU SRP Publications


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