Documents

Publications by CU SRP Project & Core Scientists

2015     2014     2013     2012     2011     2010     2009     2008     2007     2005/2006


2015 Publications

 

All Projects and Cores

Argos M, Chen L, Jasmine F, Tong L, Pierce BL, Roy S, Paul-Brutus R, Gamble MV, Harper KN, Parvez F, Rahman M, Rakibuz-Zaman M, Slavkovich V, Baron JA, Graziano JH, Kibriya MG, Ahsan H. Gene-specific differential DNA methylation and chronic arsenic exposure in an epigenome-wide association study of adults in Bangladesh. Environ Health Perspect. 2015 Jan; 123(1):64–71. Epub 2014 Oct 17. PMID: 25325195; PMCID: PMC4286273. http://dx.doi.org/10.1289/ehp.1307884

Aschebrook-Kilfoy B, Argos M, Pierce BL, Tong L, Jasmine F, Roy S, Parvez F, Ahmed A, Islam T, Kibriya MG, Ahsan H. Genome-wide association study of parity in Bangladeshi women. PLoS One. 2015 Mar 5; 10(3):e0118488. PMID: 25742292; PMCID: PMC4350917. http://dx.doi.org/10.1371/journal.pone.0118488

Farzan SF, Karagas MR, Jiang J, Wu F, Liu M, Newman JD, Jasmine F, Kibriya MG, Paul-Brutus R, Parvez F, Argos M, Bryan MS, Eunus M, Ahmed A, Islam T, Rakibuz-Zaman M, Hasan R, Sarwar G, Slavkovich V, Graziano J, Ahsan H, Chen Y. Gene-arsenic interaction in longitudinal changes of blood pressure: Findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh. Toxicol Appl Pharmacol. 2015 Oct 1; 288(1):95–105. Epub 2015 Jul 26. PMID: 26220686; PMCID: PMC4606937. http://dx.doi.org/10.1016/j.taap.2015.07.017

Flanagan SV, Marvinney RG, Zheng Y. Influences on domestic well water testing behavior in a Central Maine area with frequent groundwater arsenic occurrence. Sci Total Environ. 2015 Feb 1; 505:1274–1281. Epub 2014 May 26. PMID: 24875279; PMCID: PMC4245378. http://dx.doi.org/10.1016/j.scitotenv.2014.05.017

Flanagan SV, Marvinney RG, Johnston RA, Yang Q, Zheng Y. Dissemination of well water arsenic results to homeowners in Central Maine: Influences on mitigation behavior and continued risks for exposure. Sci Total Environ. 2015 Feb 1; 505:1282–1290. Epub 2014 Apr 13. PMID: 24726512; PMCID: PMC4192113. http://dx.doi.org/10.1016/j.scitotenv.2014.03.079

Gao J, Roy S, Tong L, Argos M, Jasmine F, Rahaman R, Rakibuz-Zaman M, Parvez F, Ahmed A, Hore SK, Sarwar G, Slavkovich V, Yunus M, Rahman M, Baron JA, Graziano JH, Ahsan H, Pierce BL. Arsenic exposure, telomere length, and expression of telomere-related genes among Bangladeshi individuals. Environ Res. 2015 Jan; 136:462–469. Epub 2014 Nov 25. PMID: 25460668; PMCID: PMC4264833. http://dx.doi.org/10.1016/j.envres.2014.09.040

Gao J, Tong L, Argos M, Bryan MS, Ahmed A, Rakibuz-Zaman M, Kibriya MG, Jasmine F, Slavkovich V, Graziano JH, Ahsan H, Pierce BL. The genetic architecture of arsenic metabolism efficiency: A SNP-based heritability study of Bangladeshi adults. Environ Health Perspect. 2015 Oct; 123(10):985–992. Epub 2015 Mar 13. PMID: 25768001; PMCID: PMC4590755. http://dx.doi.org/10.1289/ehp.1408909

George, CM, Brooks WA, Graziano JH, Nonyane BA, Hossain L, Goswami D, Zaman K, Yunus M, Khan AF, Jahan Y, Ahmed D, Slavkovich V, Higdon M, Deloria-Knoll M, O' Brien KL. Arsenic exposure is associated with pediatric pneumonia in rural Bangladesh: a case control study. Environ Health. 2015 Oct 23; 14:83. PMID: 26497043; PMCID: PMC4619558. http://dx.doi.org/10.1186/s12940-015-0069-9

Howe CG and Gamble MV. Enzymatic cleavage of histone H3: a new consideration when measuring histone modifications in human samples. Clin Epigen. 2015 Jan 22; 7(1):7. PMID: 25628766; PMCID: PMC4307743. http://dx.doi.org/10.1186/s13148-014-0041-5

Jansen RJ, Argos M, Tong L, Li J, Rakibuz-Zaman M, Islam MT, Slavkovich V, Ahmed A, Navas-Acien A, Parvez F, Chen Y, Gamble MV, Graziano JH, Pierce BL, Ahsan H. Determinants and consequences of arsenic metabolism efficiency among 4,794 individuals: demographics, lifestyle, genetics, and toxicity. Cancer Epidemiol Biomarkers Prev. 2016 Feb; 25(2):381-390. Epub 2015 Dec 16. PMID: 26677206; PMCID: PMC4767610. doi: 10.1158/1055-9965.epi-15-0718. http://cebp.aacrjournals.org/content/25/2/381.abstract

Jiang J, Liu M, Parvez F, Wang B, Wu F, Eunus M, Bangalore S, Ahmed A, Islam T, Rakibuz-Zaman M, Hasan R, Sarwar G, Levy D, Argos M, Scannell Bryan M, Graziano J, Hayes RB, Ahsan H, Chen Y. Association of major dietary patterns and blood pressure longitudinal change in Bangladesh. J Hypertens. 2015 June; 33(6):1193–1200. PMID: 25693059; PMCID: PMC4606930. http://dx.doi.org/10.1097/HJH.0000000000000534

Jiang J, Liu M, Parvez F, Wang B, Wu F, Eunus M, Bangalore S, Newman JD, Ahmed A, Islam T, Rakibuz-Zaman M, Hasan R, Sarwar G, Levy D, Slavkovich V, Argos M, Scannell Bryan M, Farzan SF, Hayes RB, Graziano JH, Ahsan H, Chen Y. Association between arsenic exposure from drinking water and longitudinal change in blood pressure among HEALS cohort participants. Environ Health Perspect. 2015 Aug; 123(8):806–812. Epub 2015 Mar 27. PMID: 25816368; PMCID: PMC4529016. http://dx.doi.org/10.1289/ehp.1409004

Karagas MR, Gossai A, Pierce B, Ahsan H. Drinking water arsenic contamination, skin lesions, and malignancies: A systematic review of the global evidence. Curr Environ Health Rep. 2015 Mar; 2(1):52–68. PMID: 26231242; PMCID: PMC4522704. http://dx.doi.org/10.1007/s40572-014-0040-x

Khan K, Ahmed E, Factor-Litvak P, Liu X, Siddique AB, Wasserman GA, Slavkovich V, Levy D, Mey JL, van Geen A, Graziano JH. Evaluation of an elementary school-based educational intervention for arsenic exposure in Bangladesh. Environ Health Perspect. 2015 Dec; 123(12):1331–1336. Epub 2015 May 8. PMID: 25956010; PMCID: PMC4671245 http://dx.doi.org/10.1289/ehp.1409462

Muñoz A, Chervona Y, Hall M, Kluz T, Gamble MV, Costa M. Sex-specific patterns and deregulation of endocrine pathways in the gene expression profiles of Bangladeshi adults exposed to arsenic contaminated drinking water. Toxicol Appl Pharmacol. 2015 May 1; 284(3):330–338. Epub 2015 Mar 7. PMID: 25759245; PMCID: PMC4410068. http://dx.doi.org/10.1016/j.taap.2015.02.025

Niedzwiecki MM, Liu X, Hall MN, Thomas T, Slavkovich V, Ilievski V, Levy D, Alam S, Siddique AB, Parvez F, Graziano JH, Gamble MV. Sex-specific associations of arsenic exposure with global DNA methylation and hydroxymethylation in leukocytes: Results from two studies in Bangladesh. Cancer Epidemiol Biomarkers Prev. 2015 Nov; 24(11):1748-1757. Epub 2015 Sep 12. PMID: 26364164; PMCID: PMC4633312. doi: 10.1158/1055-9965. http://cebp.aacrjournals.org/content/24/11/1748.abstract

Pesola GR, Argos M, Chen Y, Parvez F, Ahmed A, Hasan R, Rakibuz-Zaman M, Islam T, Eunus M, Sarwar G, Chinchilli VM, Neugut AI, Ahsan H. Dipstick proteinuria as a predictor of all-cause and cardiovascular disease mortality in Bangladesh: A prospective cohort study. Prev Med. 2015 Sep; 78:72–77. Epub 2015 Jul 17. PMID: 26190365; PMCID: PMC4718561. http://dx.doi.org/10.1016/j.ypmed.2015.07.009

Peters BA, Hall MN, Liu X, Parvez F, Sanchez TR, van Geen A, Mey JL, Siddique AB, Shahriar H, Uddin MN, Islam T, Balac O, Ilievski V, Factor-Litvak P, Graziano JH, Gamble MV. Folic acid and creatine as therapeutic approaches to lower blood arsenic: A randomized-controlled trial. Environ Health Perspect. 2015 Dec; 123(12):1294–1301. PMID: 25978852; PMCID: PMC4671237. http://dx.doi.org/10.1289/ehp.1409396

Peters BA, Hall MN, Liu X, Parvez F, Siddique AB, Shahriar H, Uddin MN, Islam T, Ilievski V, Graziano JH, Gamble MV. Low-dose creatine supplementation lowers plasma guanidinoacetate, but not plasma homocysteine, in a double-blind, randomized, placebo-controlled trial. J Nutr 2015 Oct; 145(10):2245–2252. Epub 2015 Aug 26. PMID: 26311810; PMCID: PMC4580963. doi: 10.3945/jn.115.216739. http://jn.nutrition.org/content/145/10/2245.abstract

Peters BA, Hall MN, Liu X, Slavkovich V, Ilievski V, Alam S, Siddique AB, Islam T, Graziano JH, Gamble MV. Renal function is associated with indicators of arsenic methylation capacity in Bangladeshi adults. Environ Research. 2015 Nov; 143(Part A):123–130. Epub 2015 Oct 19. PMID: 26476787; PMCID: PMC4740972. http://dx.doi.org/10.1016/j.envres.2015.10.001

Peters BA, Liu X, Hall MN, Ilievski V, Slavkovich V, Siddique AB, Alam S, Islam T, Graziano JH, Gamble MV. Arsenic exposure, inflammation, and renal function in Bangladeshi adults: effect modification by plasma glutathione redox potential. Free Rad Biol Med. 2015 Aug; 85:174–182. Epub 2015 Apr 24. PMID: 25916185; PMCID: PMC4679178. http://dx.doi.org/10.1016/j.freeradbiomed.2015.04.020

Radloff KA, Zheng Y, Stute M, Weinman B, Bostick B, Mihajlov I, Bounds M, Rahman MM, Huq MR, Ahmed KM, Schlosser P, van Geen A. Reversible adsorption and flushing of arsenic in a shallow, Holocene aquifer of Bangladesh. Applied Geochemistry. Available online 2015 Nov 23. http://dx.doi.org/10.1016/j.apgeochem.2015.11.003

Reed MC, Gamble MV, Hall MN, Nijhout HF. Mathematical analysis of the regulation of competing methyltransferases. BMC Syst Biol. 2015 Oct 14; 9:69. PMID: 26467983; PMCID: PMC4606511. http://dx.doi.org/10.1186/s12918-015-0215-6

Stanton BA, Caldwell K, Congdon CB, Disney J, Donahue M, Ferguson E, Flemings E, Golden M, Guerinot ML, Highman J, James K, Kim C, Lantz RC, Marvinney RG, Mayer G, Miller D, Navas-Acien A, Nordstrom DK, Postema S, Rardin L, Rosen B, SenGupta A, Shaw J, Stanton E, Susca P. MDI Biological Laboratory Arsenic Summit: Approaches to Limiting Human Exposure to Arsenic. Curr Environ Health Rep. 2015 Sept; 2(3):329–337. PMID: 26231509; PMCID: PMC4522277. http://dx.doi.org/10.1007/s40572-015-0057-9

Sun J, Chillrud SN, Mailloux BJ, Stute M, Singh R, Dong H, Lepre CJ, Bostick BC. Enhanced and stabilized arsenic retention in microcosms through the microbial oxidation of ferrous iron by nitrate. Chemosphere 2016 Feb; 144:1106–1115. Epub 2015 Oct 23. PMID: 26454120; PMCID: PMC4779597. http://dx.doi.org/10.1016/j.chemosphere.2015.09.045

van Geen A, Ahmed KM, Ahmed EB, Choudhurry I, Mozumder MR, Bostick BC, Mailloux BJ. Inequitable allocation of deep community wells for reducing arsenic exposure in Bangladesh. J Water Sanit and Hyg Dev. 2016 Mar; 6(1):142–150. Epub 2015 Dec 15. PMID: 27087915; PMCID: PMC4827352. http://dx.doi.org/10.2166/washdev.2015.115

Wasserman GA, Liu X, Parvez F, Factor-Litvak P, Kline J, Siddique AB, Shahriar H, Uddin MN, van Geen A, Mey JL, Balac O, Graziano JH. Child intelligence and reductions in water arsenic and manganese: A two-year follow-up study in Bangladesh. Environ Health Perspect. 2016 July; 124(7):1114–1120. Epub 2015 Dec 29. PMID: 26713676; PMCID: PMC4937860. http://dx.doi.org/10.1289/ehp.1509974

Wu F, Jasmine F, Kibriya MG, Liu M, Cheng X, Parvez F, Islam T, Ahmed A, Rakibuz-Zaman M, Jiang J, Roy S, Paul-Brutus R, Slavkovich V, Islam T, Levy D, VanderWeele TJ, Pierce BL, Graziano JH, Ahsan H, Chen Y. Interaction between arsenic exposure from drinking water and genetic polymorphisms on cardiovascular disease in Bangladesh: a prospective case-cohort study. Environ Health Perspect. 2015 May; 123(5):451–457. Epub 2015 Jan 9. PMID: 25575156; PMCID: PMC4421763. http://dx.doi.org/10.1289/ehp.1307883

Wu F, Parvez F, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Argos M, Levy D, Sarwar G, Ahsan H, Chen Y. Betel quid use and mortality in Bangladesh: a cohort study. Bull World Health Organ. 2015 Oct 1; 93(10):684–692. Epub 2015 Jun 25. PMID: 26600610; PMCID: PMC4645429. http://dx.doi.org/10.2471/BLT.14.149484

Zheng Y, Ayotte JD. At the crossroads: Hazard assessment and reduction of health risks from arsenic in private well waters of the northeastern United States and Atlantic Canada. Sci Total Environ. 2015 Feb 1; 505:1237–1247. Epub 2014 Nov 18. PMID: 25466685; PMCID: PMC4386837. http://dx.doi.org/10.1016/j.scitotenv.2014.10.089


Project 1: Health Effects of Arsenic Longitudinal Study (HEALS)

Argos M, Chen L, Jasmine F, Tong L, Pierce BL, Roy S, Paul-Brutus R, Gamble MV, Harper KN, Parvez F, Rahman M, Rakibuz-Zaman M, Slavkovich V, Baron JA, Graziano JH, Kibriya MG, Ahsan H. Gene-specific differential DNA methylation and chronic arsenic exposure in an epigenome-wide association study of adults in Bangladesh. Environ Health Perspect. 2015 Jan; 123(1):64–71. PMID: 25325195; PMCID: PMC4286273. http://dx.doi.org/10.1289/ehp.1307884

Aschebrook-Kilfoy B, Argos M, Pierce BL, Tong L, Jasmine F, Roy S, Parvez F, Ahmed A, Islam T, Kibriya MG, Ahsan H. Genome-wide association study of parity in Bangladeshi women. PLoS One. 2015 Mar 5; 10(3):e0118488. PMID: 25742292; PMCID: PMC4350917. http://dx.doi.org/10.1371/journal.pone.0118488

Farzan SF, Karagas MR, Jiang J, Wu F, Liu M, Newman JD, Jasmine F, Kibriya MG, Paul-Brutus R, Parvez F, Argos M, Bryan MS, Eunus M, Ahmed A, Islam T, Rakibuz-Zaman M, Hasan R, Sarwar G, Slavkovich V, Graziano J, Ahsan H, Chen Y. Gene-arsenic interaction in longitudinal changes of blood pressure: Findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh. Toxicol Appl Pharmacol. 2015 Oct 1; 288(1):95–105. Epub 2015 Jul 26. PMID: 26220686; PMCID: PMC4606937. http://dx.doi.org/10.1016/j.taap.2015.07.017

Gao J, Roy S, Tong L, Argos M, Jasmine F, Rahaman R, Rakibuz-Zaman M, Parvez F, Ahmed A, Hore SK, Sarwar G, Slavkovich V, Yunus M, Rahman M, Baron JA, Graziano JH, Ahsan H, Pierce BL. Arsenic exposure, telomere length, and expression of telomere-related genes among Bangladeshi individuals. Environ Res. 2015 Jan; 136:462–469. Epub 2014 Nov 25. PMID: 25460668; PMCID: PMC4264833. http://dx.doi.org/10.1016/j.envres.2014.09.040

Gao J, Tong L, Argos M, Bryan MS, Ahmed A, Rakibuz-Zaman M, Kibriya MG, Jasmine F, Slavkovich V, Graziano JH, Ahsan H, Pierce BL. The genetic architecture of arsenic metabolism efficiency: A SNP-based heritability study of Bangladeshi adults. Environ Health Perspect. 2015 Oct; 123(10):985–992. Epub 2015 Mar 13. PMID: 25768001; PMCID: PMC4590755. http://dx.doi.org/10.1289/ehp.1408909

Jansen RJ, Argos M, Tong L, Li J, Rakibuz-Zaman M, Islam MT, Slavkovich V, Ahmed A, Navas-Acien A, Parvez F, Chen Y, Gamble MV, Graziano JH, Pierce BL, Ahsan H. Determinants and consequences of arsenic metabolism efficiency among 4,794 individuals: demographics, lifestyle, genetics, and toxicity. Cancer Epidemiol Biomarkers Prev. 2016 Feb; 25(2):381-390. Epub 2015 Dec 16. PMID: 26677206; PMCID: PMC4767610. doi: 10.1158/1055-9965.epi-15-0718. http://cebp.aacrjournals.org/content/25/2/381.abstract

Jiang J, Liu M, Parvez F, Wang B, Wu F, Eunus M, Bangalore S, Ahmed A, Islam T, Rakibuz-Zaman M, Hasan R, Sarwar G, Levy D, Argos M, Scannell Bryan M, Graziano J, Hayes RB, Ahsan H, Chen Y. Association of major dietary patterns and blood pressure longitudinal change in Bangladesh. J Hypertens. 2015 June; 33(6):1193–1200. PMID: 25693059; PMCID: PMC4606930. http://dx.doi.org/10.1097/HJH.0000000000000534

Jiang J, Liu M, Parvez F, Wang B, Wu F, Eunus M, Bangalore S, Newman JD, Ahmed A, Islam T, Rakibuz-Zaman M, Hasan R, Sarwar G, Levy D, Slavkovich V, Argos M, Scannell Bryan M, Farzan SF, Hayes RB, Graziano JH, Ahsan H, Chen Y. Association between arsenic exposure from drinking water and longitudinal change in blood pressure among HEALS cohort participants. Environ Health Perspect. 2015 Aug; 123(8):806–812. Epub 2015 Mar 27. PMID: 25816368; PMCID: PMC4529016. http://dx.doi.org/10.1289/ehp.1409004

Karagas MR, Gossai A, Pierce B, Ahsan H. Drinking water arsenic contamination, skin lesions, and malignancies: A systematic review of the global evidence. Curr Environ Health Rep. 2015 Mar; 2(1):52–68. PMID: 26231242; PMCID: PMC4522704. http://dx.doi.org/10.1007/s40572-014-0040-x

Pesola GR, Argos M, Chen Y, Parvez F, Ahmed A, Hasan R, Rakibuz-Zaman M, Islam T, Eunus M, Sarwar G, Chinchilli VM, Neugut AI, Ahsan H. Dipstick proteinuria as a predictor of all-cause and cardiovascular disease mortality in Bangladesh: A prospective cohort study. Prev Med. 2015 Sep; 78:72–77. Epub 2015 Jul 17. PMID: 26190365; PMCID: PMC4718561. http://dx.doi.org/10.1016/j.ypmed.2015.07.009

Wu F, Jasmine F, Kibriya MG, Liu M, Cheng X, Parvez F, Islam T, Ahmed A, Rakibuz-Zaman M, Jiang J, Roy S, Paul-Brutus R, Slavkovich V, Islam T, Levy D, VanderWeele TJ, Pierce BL, Graziano JH, Ahsan H, Chen Y. Interaction between arsenic exposure from drinking water and genetic polymorphisms on cardiovascular disease in Bangladesh: a prospective case-cohort study. Environ Health Perspect. 2015 May; 123(5):451–457. Epub 2015 Jan 9. PMID: 25575156; PMCID: PMC4421763. http://dx.doi.org/10.1289/ehp.1307883


Project 2: Consequences of Arsenic & Manganese Exposure on Children’s Health

George, CM, Brooks WA, Graziano JH, Nonyane BA, Hossain L, Goswami D, Zaman K, Yunus M, Khan AF, Jahan Y, Ahmed D, Slavkovich V, Higdon M, Deloria-Knoll M, O' Brien KL. Arsenic exposure is associated with pediatric pneumonia in rural Bangladesh: a case control study. Environ Health. 2015 Oct 23; 14:83. PMID: 26497043; PMCID: PMC4619558. http://dx.doi.org/10.1186/s12940-015-0069-9

Khan K, Ahmed E, Factor-Litvak P, Liu X, Siddique AB, Wasserman GA, Slavkovich V, Levy D, Mey JL, van Geen A, Graziano JH. Evaluation of an elementary school-based educational intervention for arsenic exposure in Bangladesh. Environ Health Perspect. 2015 Dec; 123(12):1331–1336. Epub 2015 May 8. PMID: 25956010; PMCID: PMC4671245 http://dx.doi.org/10.1289/ehp.1409462

Wasserman GA, Liu X, Parvez F, Factor-Litvak P, Kline J, Siddique AB, Shahriar H, Uddin MN, van Geen A, Mey JL, Balac O, Graziano JH. Child intelligence and reductions in water arsenic and manganese: A two-year follow-up study in Bangladesh. Environ Health Perspect. 2016 July; 124(7):1114–1120. Epub 2015 Dec 29. PMID: 26713676; PMCID: PMC4937860. http://dx.doi.org/10.1289/ehp.1509974


Project 3: Impact of Nutrition on Arsenic-induced Epigenetic Dysregulation

Argos M, Chen L, Jasmine F, Tong L, Pierce BL, Roy S, Paul-Brutus R, Gamble MV, Harper KN, Parvez F, Rahman M, Rakibuz-Zaman M, Slavkovich V, Baron JA, Graziano JH, Kibriya MG, Ahsan H. Gene-specific differential DNA methylation and chronic arsenic exposure in an epigenome-wide association study of adults in Bangladesh. Environ Health Perspect. 2015 Jan; 123(1):64–71. Epub 2014 Oct 17. PMID: 25325195; PMCID: PMC4286273. http://dx.doi.org/10.1289/ehp.1307884

Howe CG and Gamble MV. Enzymatic cleavage of histone H3: A new consideration when measuring histone modifications in human samples. Clin Epigen 2015 Jan 22; 7(1):7. PMID: 25628766; PMCID: PMC4307743. http://dx.doi.org/10.1186/s13148-014-0041-5

Muñoz A, Chervona Y, Hall M, Kluz T, Gamble MV, Costa M. Sex-specific patterns and deregulation of endocrine pathways in the gene expression profiles of Bangladeshi adults exposed to arsenic contaminated drinking water. Toxicol Appl Pharmacol. 2015 May 1; 284(3):330–338. Epub 2015 Mar 7. PMID: 25759245; PMCID: PMC4410068. http://dx.doi.org/10.1016/j.taap.2015.02.025

Niedzwiecki MM, Liu X, Hall MN, Thomas T, Slavkovich V, Ilievski V, Levy D, Alam S, Siddique AB, Parvez F, Graziano JH, Gamble MV. Sex-specific associations of arsenic exposure with global DNA methylation and hydroxymethylation in leukocytes: Results from two studies in Bangladesh. Cancer Epidemiol Biomarkers Prev. 2015 Nov; 24(11):1748-1757. Epub 2015 Sep 12. PMID: 26364164; PMCID: PMC4633312. doi: 10.1158/1055-9965. http://cebp.aacrjournals.org/content/24/11/1748.abstract

Peters BA, Hall MN, Liu X, Parvez F, Sanchez TR, van Geen A, Mey JL, Siddique AB, Shahriar H, Uddin MN, Islam T, Balac O, Ilievski V, Factor-Litvak P, Graziano JH, Gamble MV. Folic acid and creatine as therapeutic approaches to lower blood arsenic: A randomized-controlled trial. Environ Health Perspect. 2015 Dec; 123(12):1294–1301. PMID: 25978852; PMCID: PMC4671237. http://dx.doi.org/10.1289/ehp.1409396

Peters BA, Hall MN, Liu X, Parvez F, Siddique AB, Shahriar H, Uddin MN, Islam T, Ilievski V, Graziano JH, Gamble MV. Low-dose creatine supplementation lowers plasma guanidinoacetate, but not plasma homocysteine, in a double-blind, randomized, placebo-controlled trial. J Nutr 2015 Oct; 145(10):2245–2252. Epub 2015 Aug 26. PMID: 26311810; PMCID: PMC4580963. doi: 10.3945/jn.115.216739. http://jn.nutrition.org/content/145/10/2245.abstract

Peters BA, Hall MN, Liu X, Slavkovich V, Ilievski V, Alam S, Siddique AB, Islam T, Graziano JH, Gamble MV. Renal function is associated with indicators of arsenic methylation capacity in Bangladeshi adults. Environ Research. 2015 Nov; 143(Part A):123–130. Epub 2015 Oct 19. PMID: 26476787; PMCID: PMC4740972. http://dx.doi.org/10.1016/j.envres.2015.10.001

Peters BA, Liu X, Hall MN, Ilievski V, Slavkovich V, Siddique AB, Alam S, Islam T, Graziano JH, Gamble MV. Arsenic exposure, inflammation, and renal function in Bangladeshi adults: effect modification by plasma glutathione redox potential. Free Rad Biol Med. 2015 Aug; 85:174–182. Epub 2015 Apr 24. PMID: 25916185; PMCID: PMC4679178. http://dx.doi.org/10.1016/j.freeradbiomed.2015.04.020

Reed MC, Gamble MV, Hall MN, Nijhout HF. Mathematical analysis of the regulation of competing methyltransferases. BMC Syst Biol. 2015 Oct 14; 9:69. PMID: 26467983; PMCID: PMC4606511. http://dx.doi.org/10.1186/s12918-015-0215-6


Project 4: Arsenic, Iron, Sulfur and Organic Carbon Speciation and their impact on Groundwater Arsenic

Sun J, Chillrud SN, Mailloux BJ, Stute M, Singh R, Dong H, Lepre CJ, Bostick BC. Enhanced and stabilized arsenic retention in microcosms through the microbial oxidation of ferrous iron by nitrate. Chemosphere 2016 Feb; 144:1106–1115. Epub 2015 Oct 23. PMID: 26454120; PMCID: PMC4779597. http://dx.doi.org/10.1016/j.chemosphere.2015.09.045

Sun J, Quicksall AN, Chillrud SN, Mailloux BJ, Bostick BC. Arsenic mobilization from sediments in microcosms under sulfate reduction. Chemosphere (accepted pending changes).


Project 5: Application of Enhanced Mitigation Methods for Groundwater Arsenic at U.S. Superfund sites

Sun J, Chillrud SN, Mailloux BJ, Stute M, Singh R, Dong H, Lepre CJ, Bostick BC. Enhanced and stabilized arsenic retention in microcosms through the microbial oxidation of ferrous iron by nitrate. Chemosphere 2016 Feb; 144:1106–1115. Epub 2015 Oct 23. PMID: 26454120; PMCID: PMC4779597. http://dx.doi.org/10.1016/j.chemosphere.2015.09.045


Project 6: Defining the Sustainable Uses of Low-Arsenic Aquifers in Bangladesh

Khan K, Ahmed E, Factor-Litvak P, Liu X, Siddique AB, Wasserman GA, Slavkovich V, Levy D, Mey JL, van Geen A, Graziano JH. Evaluation of an elementary school-based educational intervention for arsenic exposure in Bangladesh. Environ Health Perspect. 2015 Dec; 123(12):1331–1336. Epub 2015 May 8. PMID: 25956010; PMCID: PMC4671245 http://dx.doi.org/10.1289/ehp.1409462

Peters BA, Hall MN, Liu X, Parvez F, Sanchez TR, van Geen A, Mey JL, Siddique AB, Shahriar H, Uddin MN, Islam T, Balac O, Ilievski V, Factor-Litvak P, Graziano JH, Gamble MV. Folic acid and creatine as therapeutic approaches to lower blood arsenic: A randomized-controlled trial. Environ Health Perspect. 2015 Dec; 123(12):1294–1301. PMID: 25978852; PMCID: PMC4671237. http://dx.doi.org/10.1289/ehp.1409396

Radloff KA, Zheng Y, Stute M, Weinman B, Bostick B, Mihajlov I, Bounds M, Rahman MM, Huq MR, Ahmed KM, Schlosser P, van Geen A. Reversible adsorption and flushing of arsenic in a shallow, Holocene aquifer of Bangladesh. Applied Geochemistry. Available online 2015 Nov 23. http://dx.doi.org/10.1016/j.apgeochem.2015.11.003

van Geen A, Ahmed KM, Ahmed EB, Choudhurry I, Mozumder MR, Bostick BC, Mailloux BJ. Inequitable allocation of deep community wells for reducing arsenic exposure in Bangladesh. J Water Sanit and Hyg Dev. 2016 Mar; 6(1):142–150. Epub 2015 Dec 15. PMID: 27087915; PMCID: PMC4827352. http://dx.doi.org/10.2166/washdev.2015.115


Core A: Data Management Core

Wu F, Parvez F, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Argos M, Levy D, Sarwar G, Ahsan H, Chen Y. Betel quid use and mortality in Bangladesh: a cohort study. Bull World Health Organ. 2015 Oct 1; 93(10):684–692. Epub 2015 Jun 25. PMID: 26600610; PMCID: PMC4645429. http://dx.doi.org/10.2471/BLT.14.149484


Core B: Trace Metals Core Laboratory

Core C: Biogeochemistry Core Laboratory

Core D: Hydrogeology Support Laboratory

There are not unique core specific publications from cores A-D but the publications from the projects above heavily rely on their contributions.


Core E: Community Engagement Core

Flanagan SV, Marvinney RG, Zheng Y. Influences on domestic well water testing behavior in a Central Maine area with frequent groundwater arsenic occurrence. Sci Total Environ. 2015 Feb 1; 505:1274–1281. Epub 2014 May 26. PMID: 24875279 ; PMCID: PMC4245378. http://dx.doi.org/10.1016/j.scitotenv.2014.05.017

Flanagan SV, Marvinney RG, Johnston RA, Yang Q, Zheng Y. Dissemination of well water arsenic results to homeowners in Central Maine: Influences on mitigation behavior and continued risks for exposure. Sci Total Environ. 2015 Feb 1; 505:1282–1290. Epub 2014 Apr 13. PMID: 24726512; PMCID: PMC4192113. http://dx.doi.org/10.1016/j.scitotenv.2014.03.079

Zheng Y, Ayotte JD. At the crossroads: Hazard assessment and reduction of health risks from arsenic in private well waters of the northeastern United States and Atlantic Canada. Sci Total Environ. 2015 Feb 1; 505:1237–1247. Epub 2014 Nov 18. PMID: 25466685; PMCID: PMC4386837. http://dx.doi.org/10.1016/j.scitotenv.2014.10.089


Research Translation Core (RTC)

Stanton BA, Caldwell K, Congdon CB, Disney J, Donahue M, Ferguson E, Flemings E, Golden M, Guerinot ML, Highman J, James K, Kim C, Lantz RC, Marvinney RG, Mayer G, Miller D, Navas-Acien A, Nordstrom DK, Postema S, Rardin L, Rosen B, SenGupta A, Shaw J, Stanton E, Susca P. MDI Biological Laboratory Arsenic Summit: Approaches to Limiting Human Exposure to Arsenic. Curr Environ Health Rep. 2015 Sept; 2(3):329–337. PMID: 26231509; PMCID: PMC4522277. http://dx.doi.org/10.1007/s40572-015-0057-9


2014 Publications

 

All Projects and Cores

Argos M, Parvez F, Rahman M, Rakibuz-Zaman M, Ahmed A, Hore SK, Islam T, Chen Y, Pierce BL, Slavkovich V, Olopade C, Yunus M, Baron JA, Graziano JH, Ahsan H. Arsenic and lung disease mortality in Bangladeshi adults. Epidemiology. 2014 Jul; 25(4):536-543. doi: 10.1097/EDE.0000000000000106. PMID: 24802365. NIHMSID: 660748

Argos M, Tong L, Pierce BL, Rakibuz-Zaman M, Ahmed A, Islam T, Rahman M, Paul-Brutus R, Rahaman R, Roy S, Jasmine F, Kibriya MG, Ahsan H. Genome-wide association study of smoking behaviours among Bangladeshi adults. J Med Genet. 2014 May; 51(5):327-333. doi: 10.1136/jmedgenet-2013-102151. Epub 2014 Mar 24. PMID: 24665060; PMCID: PMC4126189.

Chai-Onn T, Golden M. (December 2014). Superfund Site Footprints Data with metadata for direct download (http://sedac.ciesin.columbia.edu/data/collection/superfund/sets/browse): ATSDR Hazardous Waste Site Polygon Data, v2 (2010), 2.1 MB zipped shapefile, http://dx.doi.org/10.7927/H48P5XF7; ATSDR Hazardous Waste Site Polygon Data with CIESIN Modifications, v2 (2010), 1.4 MB zipped shapefile, http://dx.doi.org/10.7927/H4DF6P5Z; and U.S. EPA National Priorities List Sites with CIESIN Modifications, v2 (2014), 728 KB xls file, http://dx.doi.org/10.7927/H44X55RB. Disseminated online by NASA Socioeconomic Data and Applications Center (SEDAC) hosted by Center for International Earth Science Information Network - CIESIN - Columbia University, Palisades, NY

Chen Y, Ge W, Parvez F, Bangalore S, Eunus M, Ahmed A, Islam T, Rakibuz-Zaman M, Hasan R, Argos M, Levy D, Sarwar G, Ahsan H. A prospective study of arm circumference and risk of death in Bangladesh. Int J Epidemiol. 2014 Aug; 43(4):1187-1196. doi: 10.1093/ije/dyu082. Epub 2014 Apr 7. PMID: 24713183; PMCID: PMC4121562.

Harper, KN, Liu X, Hall MN, Ilievski V, Oka J, Calancie L, Slavkovich V, Levy D, Mey JL, van Geen A, Graziano JH, Gamble MV. A dose-response study of arsenic exposure and markers of oxidative damage in Bangladesh. J Occup Environ Med 2014 June; 56(6):652-658. PMCID:PMC4050339. doi: 10.1097/JOM.0000000000000166

Howe C, Niedzwiecki MM, Hall MN, Liu X, Ilievski V, Slavkovich V, Alam S, Siddique A, Graziano JH and Gamble MV. Folate and cobalamin modify associations between s-adenosylmethionine and methylated arsenic metabolites in arsenic-exposed Bangladeshi adults. Journal of Nutrition. 2014 May; 144(5):690-697. PMCID:PMC3985826

Lawley SD, Yun J, Gamble MV, Hall MN, Reed MC, Nijhout HF. Mathematical modeling of the effects of glutathione on arsenic methylation. Theor Biol Med Model. 2014 May 16; 11:20 PMCID: PMC4041632

Layton AC, Chauhan A, Williams DE, Mailloux B, Knappett PSK, Ferguson AS, McKay LD, Alam MJ, Matin Ahmed K, van Geen A, Sayler GS. 2014. Metagenomes of microbial communities in arsenic- and pathogen-contaminated well and surface water from Bangladesh. Genome Announc. 2014 Nov-Dec; 2(6):e01170-14. doi:10.1128/genomeA.01170-14. PMCID: PMC4239352

McClintock TR, Chen Y, Parvez F, Makarov DV, Ge W, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Slavkovich V, Bjurlin MA, Graziano JH, Ahsan H. Association between arsenic exposure from drinking water and hematuria: results from the Health Effects of Arsenic Longitudinal Study. Toxicol Appl Pharmacol. 2014 Apr 1; 276(1):21-27. doi: 10.1016/j.taap.2014.01.015. Epub 2014 Jan 28. PMID: 24486435; PMCID: PMC3959280

McClintock TR, Parvez F, Wu F, Wang W, Islam T, Ahmed A, Shaheen I, Sarwar G, Demmer RT, Desvarieux M, Ahsan H, Chen Y. Association between betel quid chewing and carotid intima-media thickness in rural Bangladesh. Int J Epidemiol. 2014 Aug; 43(4):1174-1182. doi: 10.1093/ije/dyu009. Epub 2014 Feb 17. PMID: 24550247; PMCID: PMC4121551.

Niedzwiecki MM, Hall MN, Liu X, Slavkovich V, Ilievski V, Levy D, Alam S, Siddique A, Parvez F, Graziano JH, Gamble MV. Interaction of plasma glutathione redox and folate deficiency on arsenic methylation capacity in Bangladeshi adults. Free Radical Biology and Medicine. 2014 Aug; 73:67-74. PMCID: PMC4111991. http://dx.doi.org/10.1016/j.freeradbiomed.2014.03.042

Pesola GR, Ahsan H. Dyspnea as an independent predictor of mortality. Clin Respir J. 2014 Jul 28. doi: 10.1111/crj.12191. [Epub ahead of print] PMCID: PMC4309743

Peters BA, Hall MN, Liu X, Neugut YD, Pilsner JR, Levy D, Ilievski V, Slavkovich V, Islam T, Factor-Litvak P, Graziano JH, Gamble MV. Creatinine, arsenic metabolism, and renal function in an arsenic-exposed population in Bangladesh. PLoS ONE 2014 Dec.1; 9(12): e113760. doi: 10.1371/journal.pone.0113760

Scannell BM, Argos M, Pierce B, Tong L, Rakibuz-Zaman M, Ahmed A, Rahman M, Islam T, Yunus M, Parvez F, Roy S, Jasmine F, Baron JA, Kibriya MG, Ahsan H. Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults. PLoS ONE 2014 Aug. 18; 9(8):e105062. doi: 10.1371/journal.pone.0105062. eCollection 2014. PMID: 25133637; PMCID: PMC4136799.

Stahl MO, Ong JB, Harvey CF, Johnson CD, Badruzzaman ABM, Tarek MH, van Geen A, Anderson JA, Lane JW. Detecting well casing leaks in Bangladesh using a salt spiking method. Groundwater 2014 Sep.; 52(S1):195–200. doi: 10.1111/gwat.12200.

van Geen A, Sumon EBA, Pitcher L, Mey JL, Ahsan H, Graziano JH, Ahmed KM. Comparison of two blanket surveys of arsenic in tubewells conducted 12 years apart in a 25 km2 area of Bangladesh. Sci Tot Environ 2014 Aug. 1; 488-489:484-492. PMCID: PMC4043877. http://dx.doi.org/10.1016/j.scitotenv.2013.12.049

van Geen A, Win KH, Zaw T, Naing W, Mey JL, Mailloux B. Confirmation of elevated arsenic levels in groundwater of Myanmar. Sci Tot Environ 2014 April 15; 478:21-24. PMCID: PMC3954970. http://dx.doi.org/10.1016/j.scitotenv.2014.01.073

Wasserman G, Liu X, LoIacono NJ, Kline J, Factor-Litvak P, van Geen A, Mey JL, Levy D, Abramson R, Schwartz A, Graziano JH. A cross-sectional study of well water arsenic and child IQ Maine schoolchildren. Environmental Health 2014 April 1; 13:23. doi:10.1186/1476-069X-13-23. PMCID: PMC4104994. http://www.ehjournal.net/content/13/1/23

Wovkulich K, Stute M, Mailloux BJ, Keimowitz AR, Ross J, Bostick B, Sun J, and Chillrud SN. In situ oxalic acid injection to accelerate arsenic remediation at a Superfund site in New Jersey. Environmental Chemistry 2014 Sep. 25; 11(5):525-537. doi:10.1071/EN13222. PMID:25598701 PMCID: PMC4294815. http://dx.doi.org/10.1071/EN13222

Wu F, Jasmine F, Kibriya MG, Liu M, Cheng X, Parvez F, Paul-Brutus R, Paul RR, Sarwar G, Ahmed A, Jiang J, Islam T, Slavkovich V, Rundek T, Demmer RT, Desvarieux M, Ahsan H, Chen Y. Interaction between arsenic exposure from drinking water and genetic susceptibility in carotid intima-media thickness in Bangladesh. Toxicol Appl Pharmacol. 2014 May 1; 276(3):195-203. doi: 10.1016/j.taap.2014.02.014. PMID: 24593923; PMCID: PMC4080412. http://dx.doi.org/10.1016/j.taap.2014.02.014

Zheng W, McLerran DF, Rolland BA, Fu Z, Boffetta P, He J, Gupta PC, Ramadas K, Tsugane S, Irie F, Tamakoshi A, Gao YT, Koh WP, Shu XO, Ozasa K, Nishino Y, Tsuji I, Tanaka H, Chen CJ, Yuan JM, Ahn YO, Yoo KY, Ahsan H, Pan WH, Qiao YL, Gu D, Pednekar MS, Sauvaget C, Sawada N, Sairenchi T, Yang G, Wang R, Xiang YB, Ohishi W, Kakizaki M, Watanabe T, Oze I, You SL, Sugawara Y, Butler LM, Kim DH, Park SK, Parvez F, Chuang SY, Fan JH, Shen CY, Chen Y, Grant EJ, Lee JE, Sinha R, Matsuo K, Thornquist M, Inoue M, Feng Z, Kang D, Potter JD. Burden of total and cause-specific mortality related to tobacco smoking among adults aged ≥ 45 years in Asia: a pooled analysis of 21 cohorts. PLoS Med. 2014 Apr 22; 11(4):e1001631. doi: 10.1371/journal.pmed.1001631. eCollection 2014 Apr. PMID: 24756146; PMCID: PMC3995657.

Additional Submissions:

Knappett, PSK, Mailloux BJ, Choudhury I, Khan M, Michael H, Barua S, Mondal DR, Steckler M, Akter H, Ahmed KM, Bostick B, Harvey C, Shamsudduha M, Mihajlov I, Mozumder R, van Geen A. Vulnerability of intermediate and deep low-arsenic aquifers to municipal pumping in Bangladesh. Revision submitted to Environ Sci & Technol, December 2014

Pfaff A, Schoenfeld A, Ahmed KM, van Geen A. Reducing arsenic exposure in Bangladesh: New evidence of the impacts of insufficient testing and health-risk communication from a tubewell and household survey. Submitted to J Health, Population & Nutr, October 2014

Sun J, Chillrud SN, Mailloux BJ, Stute M, Singh R, Dong H, Lepre C, Bostick BC. Enhanced arsenic retention in microcosms containing magnetite formed through the oxidation of ferrous iron by nitrate. Submitted

van Geen A, Ahmed KM, Ahmed EB, Choudhurry I, Mozumder MR, Bostick BC, Mailloux BJ. Increasing the impact of deep-well installations to reduce arsenic exposure in Bangladesh. Submitted to Environ Sci & Technol, November 2014.


Project 1: A Cohort Study of Health Effects of Arsenic Exposure in Bangladesh

Argos M, Parvez F, Rahman M, Rakibuz-Zaman M, Ahmed A, Hore SK, Islam T, Chen Y, Pierce BL, Slavkovich V, Olopade C, Yunus M, Baron JA, Graziano JH, Ahsan H. Arsenic and lung disease mortality in Bangladeshi adults. Epidemiology. 2014 Jul; 25(4):536-543. doi: 10.1097/EDE.0000000000000106. PMID: 24802365. NIHMSID: 660748

Argos M, Tong L, Pierce BL, Rakibuz-Zaman M, Ahmed A, Islam T, Rahman M, Paul-Brutus R, Rahaman R, Roy S, Jasmine F, Kibriya MG, Ahsan H. Genome-wide association study of smoking behaviours among Bangladeshi adults. J Med Genet. 2014 May; 51(5):327-333. doi: 10.1136/jmedgenet-2013-102151. Epub 2014 Mar 24. PMID: 24665060; PMCID: PMC4126189.

Chen Y, Ge W, Parvez F, Bangalore S, Eunus M, Ahmed A, Islam T, Rakibuz-Zaman M, Hasan R, Argos M, Levy D, Sarwar G, Ahsan H. A prospective study of arm circumference and risk of death in Bangladesh. Int J Epidemiol. 2014 Aug; 43(4):1187-1196. doi: 10.1093/ije/dyu082. Epub 2014 Apr 7. PMID: 24713183; PMCID: PMC4121562.

McClintock TR, Chen Y, Parvez F, Makarov DV, Ge W, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Slavkovich V, Bjurlin MA, Graziano JH, Ahsan H. Association between arsenic exposure from drinking water and hematuria: results from the Health Effects of Arsenic Longitudinal Study. Toxicol Appl Pharmacol. 2014 Apr 1; 276(1):21-27. doi: 10.1016/j.taap.2014.01.015. Epub 2014 Jan 28. PMID: 24486435; PMCID: PMC3959280

McClintock TR, Parvez F, Wu F, Wang W, Islam T, Ahmed A, Shaheen I, Sarwar G, Demmer RT, Desvarieux M, Ahsan H, Chen Y. Association between betel quid chewing and carotid intima-media thickness in rural Bangladesh. Int J Epidemiol. 2014 Aug; 43(4):1174-1182. doi: 10.1093/ije/dyu009. Epub 2014 Feb 17. PMID: 24550247; PMCID: PMC4121551.

Pesola GR, Ahsan H. Dyspnea as an independent predictor of mortality. Clin Respir J. 2014 Jul 28. doi: 10.1111/crj.12191. [Epub ahead of print] PMCID: PMC4309743

Scannell BM, Argos M, Pierce B, Tong L, Rakibuz-Zaman M, Ahmed A, Rahman M, Islam T, Yunus M, Parvez F, Roy S, Jasmine F, Baron JA, Kibriya MG, Ahsan H. Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults. PLoS ONE 2014 Aug. 18; 9(8):e105062. doi: 10.1371/journal.pone.0105062. eCollection 2014. PMID: 25133637; PMCID: PMC4136799.

Wu F, Jasmine F, Kibriya MG, Liu M, Cheng X, Parvez F, Paul-Brutus R, Paul RR, Sarwar G, Ahmed A, Jiang J, Islam T, Slavkovich V, Rundek T, Demmer RT, Desvarieux M, Ahsan H, Chen Y. Interaction between arsenic exposure from drinking water and genetic susceptibility in carotid intima-media thickness in Bangladesh. Toxicol Appl Pharmacol. 2014 May 1; 276(3):195-203. doi: 10.1016/j.taap.2014.02.014. PMID: 24593923; PMCID: PMC4080412. http://dx.doi.org/10.1016/j.taap.2014.02.014

Zheng W, McLerran DF, Rolland BA, Fu Z, Boffetta P, He J, Gupta PC, Ramadas K, Tsugane S, Irie F, Tamakoshi A, Gao YT, Koh WP, Shu XO, Ozasa K, Nishino Y, Tsuji I, Tanaka H, Chen CJ, Yuan JM, Ahn YO, Yoo KY, Ahsan H, Pan WH, Qiao YL, Gu D, Pednekar MS, Sauvaget C, Sawada N, Sairenchi T, Yang G, Wang R, Xiang YB, Ohishi W, Kakizaki M, Watanabe T, Oze I, You SL, Sugawara Y, Butler LM, Kim DH, Park SK, Parvez F, Chuang SY, Fan JH, Shen CY, Chen Y, Grant EJ, Lee JE, Sinha R, Matsuo K, Thornquist M, Inoue M, Feng Z, Kang D, Potter JD. Burden of total and cause-specific mortality related to tobacco smoking among adults aged ≥ 45 years in Asia: a pooled analysis of 21 cohorts. PLoS Med. 2014 Apr 22; 11(4):e1001631. doi: 10.1371/journal.pmed.1001631. eCollection 2014 Apr. PMID: 24756146; PMCID: PMC3995657.


Project 2: Consequences of Arsenic and Manganese Exposure on Children

Wasserman G, Liu X, LoIacono NJ, Kline J, Factor-Litvak P, van Geen A, Mey JL, Levy D, Abramson R, Schwartz A, Graziano JH. A cross-sectional study of well water arsenic and child IQ Maine schoolchildren. Environmental Health 2014 April 1; 13:23. doi:10.1186/1476-069X-13-23. PMCID: PMC4104994. http://www.ehjournal.net/content/13/1/23


Project 3: Impact of Nutrition on Arsenic-induced Epigenetic Dysregulation

Harper, KN, Liu X, Hall MN, Ilievski V, Oka J, Calancie L, Slavkovich V, Levy D, Mey JL, van Geen A, Graziano JH, Gamble MV. A dose-response study of arsenic exposure and markers of oxidative damage in Bangladesh. J Occup Environ Med 2014 June; 56(6):652-658. PMCID:PMC4050339. doi: 10.1097/JOM.0000000000000166

Howe C, Niedzwiecki MM, Hall MN, Liu X, Ilievski V, Slavkovich V, Alam S, Siddique A, Graziano JH and Gamble MV. Folate and cobalamin modify associations between s-adenosylmethionine and methylated arsenic metabolites in arsenic-exposed Bangladeshi adults. Journal of Nutrition. 2014 May; 144(5):690-697. PMCID:PMC3985826

Lawley SD, Yun J, Gamble MV, Hall MN, Reed MC, Nijhout HF. Mathematical modeling of the effects of glutathione on arsenic methylation. Theor Biol Med Model. 2014 May 16; 11:20 PMCID: PMC4041632

Niedzwiecki MM, Hall MN, Liu X, Slavkovich V, Ilievski V, Levy D, Alam S, Siddique A, Parvez F, Graziano JH, Gamble MV. Interaction of plasma glutathione redox and folate deficiency on arsenic methylation capacity in Bangladeshi adults. Free Radical Biology and Medicine. 2014 Aug; 73:67-74. PMCID: PMC4111991. http://dx.doi.org/10.1016/j.freeradbiomed.2014.03.042

Peters BA, Hall MN, Liu X, Neugut YD, Pilsner JR, Levy D, Ilievski V, Slavkovich V, Islam T, Factor-Litvak P, Graziano JH, Gamble MV. Creatinine, arsenic metabolism, and renal function in an arsenic-exposed population in Bangladesh. PLoS ONE 2014 Dec.1; 9(12): e113760. doi: 10.1371/journal.pone.0113760


Project 4: Arsenic, Iron, Sulfur and Organic Carbon Speciation

Layton AC, Chauhan A, Williams DE, Mailloux B, Knappett PSK, Ferguson AS, McKay LD, Alam MJ, Matin Ahmed K, van Geen A, Sayler GS. 2014. Metagenomes of microbial communities in arsenic- and pathogen-contaminated well and surface water from Bangladesh. Genome Announc. 2014 Nov-Dec; 2(6):e01170-14. doi:10.1128/genomeA.01170-14. PMCID: PMC4239352

Wovkulich K, Stute M, Mailloux BJ, Keimowitz AR, Ross J, Bostick B, Sun J, and Chillrud SN. In situ oxalic acid injection to accelerate arsenic remediation at a Superfund site in New Jersey. Environmental Chemistry 2014 Sep. 25; 11(5):525-537. doi:10.1071/EN13222. PMID:25598701 PMCID: PMC4294815. http://dx.doi.org/10.1071/EN13222

Additional Submissions:

Sun J, Chillrud SN, Mailloux BJ, Stute M, Singh R, Dong H, Lepre C, Bostick BC. Enhanced arsenic retention in microcosms containing magnetite formed through the oxidation of ferrous iron by nitrate. Submitted


Project 5: Application of Enhanced Mitigation Methods for Groundwater Arsenic at US Superfund Sites

Wovkulich K, Stute M, Mailloux BJ, Keimowitz AR, Ross J, Bostick B, Sun J, and Chillrud SN. In situ oxalic acid injection to accelerate arsenic remediation at a Superfund site in New Jersey. Environmental Chemistry 2014 Sep. 25; 11(5):525-537. doi:10.1071/EN13222. PMID:25598701 PMCID: PMC4294815. http://dx.doi.org/10.1071/EN13222

Additional Submissions:

Sun J, Chillrud SN, Mailloux BJ, Stute M, Singh R, Dong H, Lepre C, Bostick BC. Enhanced arsenic retention in microcosms containing magnetite formed through the oxidation of ferrous iron by nitrate. Submitted


Project 6: Defining the Sustainable Uses of Low-Arsenic Aquifers in Bangladesh

Harper, KN, Liu X, Hall MN, Ilievski V, Oka J, Calancie L, Slavkovich V, Levy D, Mey JL, van Geen A, Graziano JH, Gamble MV. A dose-response study of arsenic exposure and markers of oxidative damage in Bangladesh. J Occup Environ Med 2014 June; 56(6):652-658. PMCID:PMC4050339.

Layton AC, Chauhan A, Williams DE, Mailloux B, Knappett PSK, Ferguson AS, McKay LD, Alam MJ, Matin Ahmed K, van Geen A, Sayler GS. 2014. Metagenomes of microbial communities in arsenic- and pathogen-contaminated well and surface water from Bangladesh. Genome Announc. 2014 Nov-Dec; 2(6):e01170-14. doi:10.1128/genomeA.01170-14. PMCID: PMC4239352

Stahl MO, Ong JB, Harvey CF, Johnson CD, Badruzzaman ABM, Tarek MH, van Geen A, Anderson JA, Lane JW. Detecting well casing leaks in Bangladesh using a salt spiking method. Groundwater 2014 Sep.; 52(S1):195–200. doi: 10.1111/gwat.12200.

van Geen A, Sumon EBA, Pitcher L, Mey JL, Ahsan H, Graziano JH, Ahmed KM. Comparison of two blanket surveys of arsenic in tubewells conducted 12 years apart in a 25 km2 area of Bangladesh. Sci Tot Environ 2014 Aug. 1; 488-489:484-492. PMCID: PMC4043877. http://dx.doi.org/10.1016/j.scitotenv.2013.12.049

van Geen A, Win KH, Zaw T, Naing W, Mey JL, Mailloux B. Confirmation of elevated arsenic levels in groundwater of Myanmar. Sci Tot Environ 2014 April 15; 478:21-24. PMCID: PMC3954970. http://dx.doi.org/10.1016/j.scitotenv.2014.01.073

Wasserman G, Liu X, LoIacono NJ, Kline J, Factor-Litvak P, van Geen A, Mey JL, Levy D, Abramson R, Schwartz A, Graziano JH. A cross-sectional study of well water arsenic and child IQ Maine schoolchildren. Environmental Health 2014 April 1; 13:23. doi:10.1186/1476-069X-13-23. PMCID: PMC4104994. http://www.ehjournal.net/content/13/1/23

Additional Submissions:

Knappett, PSK, Mailloux BJ, Choudhury I, Khan M, Michael H, Barua S, Mondal DR, Steckler M, Akter H, Ahmed KM, Bostick B, Harvey C, Shamsudduha M, Mihajlov I, Mozumder R, van Geen A. Vulnerability of intermediate and deep low-arsenic aquifers to municipal pumping in Bangladesh. Revision submitted to Environ Sci & Technol, December 2014

Pfaff A, Schoenfeld A, Ahmed KM, van Geen A. Reducing arsenic exposure in Bangladesh: New evidence of the impacts of insufficient testing and health-risk communication from a tubewell and household survey. Submitted to J Health, Population & Nutr, October 2014

van Geen A, Ahmed KM, Ahmed EB, Choudhurry I, Mozumder MR, Bostick BC, Mailloux BJ. Increasing the impact of deep-well installations to reduce arsenic exposure in Bangladesh. Submitted to Environ Sci & Technol, November 2014.


Core A: Data Management Core

Core B: Trace Metals Core Laboratory

Core C: Biogeochemistry Core Laboratory

Core D: Hydrogeology Support Laboratory

There are not unique core specific publications from cores A-D but the publications from the projects above heavily rely on their contributions.


Core E: Community Engagement Core

Manuscripts submitted in 2014 have been published in 2015.


Research Translation Core:

Chai-Onn T, Golden M. (December 2014). Superfund Site Footprints Data with metadata for direct download (http://sedac.ciesin.columbia.edu/data/collection/superfund/sets/browse): ATSDR Hazardous Waste Site Polygon Data, v2 (2010), 2.1 MB zipped shapefile, http://dx.doi.org/10.7927/H48P5XF7; ATSDR Hazardous Waste Site Polygon Data with CIESIN Modifications, v2 (2010), 1.4 MB zipped shapefile, http://dx.doi.org/10.7927/H4DF6P5Z; and U.S. EPA National Priorities List Sites with CIESIN Modifications, v2 (2014), 728 KB xls file, http://dx.doi.org/10.7927/H44X55RB. Disseminated online by NASA Socioeconomic Data and Applications Center (SEDAC) hosted by Center for International Earth Science Information Network - CIESIN - Columbia University, Palisades, NY


2013 Publications

 

All Projects and Cores

(*-denotes publications that resulted from collaborations between project and core activities)

*Argos M, Parvez F, Rahman M, Rakibuz-Zaman M, Ahmed A, Hore SK, Islam T, Chen Y, Pierce BL, Slavkovich V, Olopade C, Yunus M, Baron JA, Graziano JH, Ahsan H. A prospective cohort study of urinary total arsenic concentration and skin lesion status in relation to malignant and non-malignant lung disease mortality in bangladeshi adults. Epidemiology 2014; In press.098/09 PMCID: in process

Argos M, Melkonian S, Parvez F, Rakibuz-Zaman M, Ahmed A, Chen Y, Ahsan H. A population-based prospective study of energy-providing nutrients in relation to all-cause cancer mortality and cancers of digestive organs mortality. Int J Cancer 2013;133:2422-8. PMCID: in process

Argos M, Rahman M, Parvez F, Dignam J, Islam T, Quasem I, K Hore S, T Haider A, Hossain Z, I Patwary T, Rakibuz-Zaman M, Sarwar G, La Porte P, Harjes J, Anton K, Kibriya MG, Jasmine F, Khan R, Kamal M, Shea CR, Yunus M, Baron JA, Ahsan H. Baseline comorbidities in a skin cancer prevention trial in Bangladesh. Eur J Clin Invest. 2013 Jun;43(6):579-88. doi: 10.1111/eci.12085. Epub 2013 Apr 17. NIHMSID: NIHMS457153

*Balasubramanya S, Pfaff A, Bennear L, Tarozzi A, Ahmed KM, Schoenfeld A, van Geen A, Evolution of households' responses to the groundwater arsenic crisis in Bangladesh: information on environmental health risks can have increasing behavioral impact over time. Environ Develop Econ 2013;pp.1-17. doi:10.1017/S1355770X13000 NIHMSID: NIHMS558341

Brocato J and Costa M. Basic mechanisms of DNA methylation and the unique landscape of the DNA methylome in metal-induced carcinogenesis. Crit Rev Toxicol 2013;43(6):493-514. PMCID: PMC3871623

*Chen Y, Wu F, Parvez F, Ahmed A, Eunus M, McClintock TR, Patwary TI, Islam T, Ghosal AK, Islam S, Hasan R, Levy D, Sarwar G, Slavkovich V, van Geen A, Graziano JH, Ahsan H. Arsenic exposure from drinking water and QT-interval prolongation: results from the Health Effects of Arsenic Longitudinal Study. Environ Health Perspect 2013;121:427-32. 432e1-7. doi: 10.1289/ehp.1205197. PMCID: PMC3620737

*Chen Y, Wu F, Liu M, Parvez F, Slavkovich V, Eunus M, Ahmed A, Argos M, Islam T, Rakibuz-Zaman M, Hasan R, Sarwar G, Levy D, Graziano J, Ahsan H. A prospective study of arsenic exposure, arsenic methylation capacity, and risk of cardiovascular disease in Bangladesh. Environ Health Perspect 2013;121:832-8. PMCID: PMC3701993

*Chen Y, Wu F, Graziano JH, Parvez F, Liu M, Paul RR, Shaheen I, Sarwar G, Ahmed A, Islam T, Slavkovich V, Rundek T, Demmer RT, Desvarieux M, Ahsan H. Arsenic exposure from drinking water, arsenic methylation capacity, and carotid intima-media thickness in Bangladesh. Am J Epidemiol 2013;178:372-81. PMCID: PMC3727341

Feighery F, Mailloux BJ, Ferguson AS, Ahmed KM, van Geen A, Culligan PJ. Transport of E. coli in aquifer sediments of Bangladesh: Implications for widespread microbial contamination of groundwater. Water Resources Res DOI: 10.1002/wrcr.20289, 2013. NIHMSID: NIHMS558342

*George CM, Gamble M, Slavkovich V, Levy D, Ahmed A, Ahsan H, Graziano J. A cross-sectional study of the impact of blood selenium on blood and urinary arsenic concentrations in Bangladesh. Environ Health 2013;12:52. doi:10.1186/1476-069X-12-52. PMCID: PMC3724573

*Hall MN, Niedzwiecki MM, Liu X, Harper KN, Alam S, Slavkovich V, Ilievski V, Levy D, Siddique AB, Parvez F, Mey JL, van Geen A, Graziano JH and Gamble MV. Chronic arsenic exposure and blood glutathione and glutathione disulfide concentrations in Bangladeshi adults. Environ Health Persp 2013;121(9):1068-74. PMCID: PMC3764071

Harper KN, Peters B, Gamble MV. Batch effects and pathway analysis: Two potential perils in cancer studies involving DNA methylation array analysis. Cancer Epidemiol Biomarkers Prev 2013;22(6):1052-60. PMCID: PMC3687782.

Knappett PK, Du J, Liu P, Horvath V, Mailloux BJ, Feighery J, van Geen A, Culligan PJ. Importance of reversible attachment in predicting E. coli transport in saturated aquifers from column experiments. Adv Water Res 2014;63:120–30. http://dx.doi.org/10.1016/j.advwatres.2013.11.005, 2013. NIHMSID: NIHMS558343

Lee JE, McLerran DF, Rolland B, Chen Y, Grant EJ, Vedanthan R, Inoue M, Tsugane S, Gao YT, Tsuji I, Kakizaki M, Ahsan H, Ahn YO, Pan WH, Ozasa K, Yoo KY, Sasazuki S, Yang G, Watanabe T, Sugawara Y, Parvez F, Kim DH, Chuang SY, Ohishi W, Park SK, Feng Z, Thornquist M, Boffetta P, Zheng W, Kang D, Potter J, Sinha R. Meat intake and cause-specific mortality: a pooled analysis of Asian prospective cohort studies. Am J Clin Nutr 2013;98:1032-41. PMCID: PMC3778858

Lin Y, Fu R, Grant E, Chen Y, Lee JE, Gupta PC, Ramadas K, Inoue M, Tsugane S, Gao YT, Tamakoshi A, Shu XO, Ozasa K, Tsuji I, Kakizaki M, Tanaka H, Chen CJ, Yoo KY, Ahn YO, Ahsan H, Pednekar MS, Sauvaget C, Sasazuki S, Yang G, Xiang YB, Ohishi W, Watanabe T, Nishino Y, Matsuo K, You SL, Park SK, Kim DH, Parvez F, Rolland B, McLerran D, Sinha R, Boffetta P, Zheng W, Thornquist M, Feng Z, Kang D, Potter JD. Association of body mass index and risk of death from pancreatic cancer in Asians: findings from the Asia Cohort Consortium. Eur J Cancer Prev 2013;22:244-50. PMCID: PMC3838869

*Mailloux BJ, Trembath-Reichert E, Cheung J, Watson M, Stute M, Freyer GA, Ferguson AS, Ahmed KM, Alam MJ, Buchholz BA, Thomas J, Layton AC, Zheng Y, Bostick BC, van Geen A. Advection of surface-derived organic carbon fuels microbial reduction in Bangladesh groundwater, PNAS 110: 5331-5, 2013. PMCID: PMC3619377

*Melkonian S, Argos M, Hall MN, Chen Y, Parvez F, Pierce B, Cao H, Aschebrook-Kilfoy B, Ahmed A, Islam T, Slavkovich V, Gamble M, Haris PI, Graziano JH, Ahsan H. Urinary and Dietary Analysis of 18,470 Bangladeshis Reveal a Correlation of Rice Consumption with Arsenic Exposure and Toxicity. PLoS ONE 2013;8(11):e80691. doi:10.1371/journal.pone.0080691 PMCID: PMC3829854

*Niedzwiecki M, Hall MN, Liu X, Oka J, Harper K, Slavkovich V, Ilievski V, Levy D, van Geen A, Mey J, Alam S, Siddique A, Parvez F, Graziano JH, Gamble MV. Blood glutathione redox status and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults. Epigenetics 2013;8(7):730-8. PMCID: PMC3781192

*Niedzwiecki MM, Hall MN, Liu X, Oka J, Harper K, Slavkovich V, Ilievski V, Levy D, van Geen A, Mey J, Alam S, Siddique AB, Parvez F, Graziano JH, Gamble MV. A Dose-response study of arsenic exposure and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults. Environ Health Persp 2013;121 (11-12):1306-12. PMCID: PMC3855504

*Parvez F, Chen Y, Yunus M, Olopade C, Segers S, Slavkovich V, Argos M, Hasan R, Ahmed A, Islam T, Akter MM, Graziano JH, Ahsan H. Arsenic exposure and impaired lung function. Findings from a large population-based prospective cohort study. Am J Respir Crit Care Med 2013;188:813-9. PMCID: PMC3826268

*Syed EH, Poudel KC, Sakisaka K, Yasuoka J, Ahsan H, Jimba M. Quality of life and mental health status of arsenic-affected patients in a Bangladeshi population. J Health Popul Nutr 2012;30:262-9. PMCID: PMC3489942

*vanGeen A, Ahmed EB, Pitcher L, Mey JL, Ahsan H, Graziano JH, Ahmed KM. Comparison of two blanket surveys of arsenic in tubewells conducted 12 years apart in a 25 km2 area of Bangladesh. Sci Tot Environ, 2014 Jan 16. pii: S0048-9697(13)01522-2. doi: 10.1016/j.scitotenv.2013.12.049. [Epub ahead of print] NIHMSID: NIHMS557871

van Geen A, Bostick BC, Pham TK, Vi ML, Nguyen-Ngoc M, Phu DM, Pham HV, Radloff K, Aziz Z, Mey JL, Stahl MO, Harvey CF, Oates P, Weinman B, Stengel C, Frei F, Kipfer R, Berg M. Retardation of arsenic transport through a Pleistocene aquifer. Nature 2013;501:204-7. doi:10.1038/nature12444. PMCID: PMC3772538

vanGeen A, Win KH, Zaw T, Naing W, Mey JL, Mailloux B. Confirmation of elevated arsenic levels in groundwater of Myanmar. Sci Tot Environ, 2014; in press. NIHMSID: NIHMS558340

Wu F, Chen Y, Parvez F, Segers S, Argos M, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Ahsan H. A prospective study of tobacco smoking and mortality in Bangladesh. PLoS One 2013;8: e58516. doi: 10.1371/journal.pone.0058516. PMCID: PMC3594295

Yinon L, Chen Y, Parvez F, Bangalore S, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Ahsan H. A prospective study of variability in systolic blood pressure and mortality in a rural Bangladeshi population cohort. Prev Med 2013;57:807-12. PMCID: in process


Project 1: A Cohort Study of Health Effects of Arsenic Exposure in Bangladesh

Argos M, Melkonian S, Parvez F, Rakibuz-Zaman M, Ahmed A, et al. A population-based prospective study of energy-providing nutrients in relation to all-cause cancer mortality and cancers of digestive organs mortality. Int J Cancer 2013;133:2422-28.

George CM, Gamble M, Slavkovich V, Levy D, Ahmed A, et al. A cross-sectional study of the impact of blood selenium on blood and urinary arsenic concentrations in Bangladesh. Environ Health 2013;12:52.

Chen Y, Wu F, Parvez F, Ahmed A, Eunus M, et al. (2013) Arsenic exposure from drinking water and QT-interval prolongation: results from the Health Effects of Arsenic Longitudinal Study. Environ Health Perspect 2013;121:427-32. , 432e421-427.

Chen Y, Wu F, Graziano JH, Parvez F, Liu M, et al. Arsenic exposure from drinking water, arsenic methylation capacity, and carotid intima-media thickness in Bangladesh. Am J Epidemiol 2013;178:372-81.

Chen Y, Wu F, Liu M, Parvez F, Slavkovich V, et al. A prospective study of arsenic exposure, arsenic methylation capacity, and risk of cardiovascular disease in Bangladesh. Environ Health Perspect 2013;121: 832-8.

Lee JE, McLerran DF, Rolland B, Chen Y, Grant EJ, et al. Meat intake and cause-specific mortality: a pooled analysis of Asian prospective cohort studies. Am J Clin Nutr 2013;98:1032-41.

Lin Y, Fu R, Grant E, Chen Y, Lee JE, et al. Association of body mass index and risk of death from pancreatic cancer in Asians: findings from the Asia Cohort Consortium. Eur J Cancer Prev 2013;22:244-50.

Melkonian S, Argos M, Hall MN, Chen Y, Parvez F, et al. Urinary and dietary analysis of 18,470 bangladeshis reveal a correlation of rice consumption with arsenic exposure and toxicity. PLoS One 2013;8: e80691.

Parvez F, Chen Y, Yunus M, Olopade C, Segers S, et al. Arsenic exposure and impaired lung function. Findings from a large population-based prospective cohort study. Am J Respir Crit Care Med 2013;188:813-9.

Syed EH, Poudel KC, Sakisaka K, Yasuoka J, Ahsan H, et al. Quality of life and mental health status of arsenic-affected patients in a Bangladeshi population. J Health Popul Nutr 2012;30:262-9.

Wu F, Chen Y, Parvez F, Segers S, Argos M, et al. A prospective study of tobacco smoking and mortality in Bangladesh. PLoS One 2013;8: e58516.

Yinon L, Chen Y, Parvez F, Bangalore S, Islam T, et al. A prospective study of variability in systolic blood pressure and mortality in a rural Bangladeshi population cohort. Prev Med 2013;57:807-12.

Additional submission

Argos M, Parvez F, Rahman M, Rakibuz-Zaman M, Ahmed A, Hore SK, Islam T, Chen Y, Pierce BL, Slavkovich V, Olopade C, Yunus M, Baron JA, Graziano JH, Ahsan H. A Prospective Cohort Study of Urinary Total Arsenic Concentration and Skin Lesion Status in relation to Malignant and Non-malignant Lung Disease Mortality in Bangladeshi Adults. Epidemiology 2014; In press.


Project 2: Consequences of Arsenic and Manganese Exposure on Children

Since this new study is still in the recruitment stage, there have been no publications yet.


Project 3: Impact of nutrition on arsenic-induced epigenetic dysregulation

Brocato J and Costa M. Basic mechanisms of DNA methylation and the unique landscape of the DNA methylome in metal-induced carcinogenesis. Crit Rev Toxicol 43(6):493-514. PMC3871623

Hall MN, Niedzwiecki MM, Liu X, Harper KN, Alam S, Slavkovich V, Ilievski V, Levy D, Siddique AB, Parvez F, Mey JL, van Geen A, Graziano JH and Gamble MV. (2013) Chronic arsenic exposure and blood glutathione and glutathione disulfide concentrations in Bangladeshi adults. Environ Health Persp 121(9):1068-74. PMCID: PMC3764071

Harper, KN, Peters, B, Gamble, MV (2013) Batch effects and pathway analysis: Two potential perils in cancer studies involving DNA methylation array analysis. Cancer Epidemiol Biomarkers Prev 22(6):1052-60. PMCID: PMC3687782.

Melkonian S, Argos M, Hall MN, Chen Y, Parvez F, Pierce B, Cao H, Aschebrook-Kilfoy B, Ahmed A, Islam T, Slavkovich V, Haris P, Gamble MV, Graziano J, Ahsan H. (2013) Urinary and Dietary Analysis of 18,470 Bangladeshis Reveal a Correlation of Rice Consumption with Arsenic Exposure and Toxicity. PLoS ONE 8(11):e80691. doi:10.1371/journal.pone.0080691 PMCID: PMC3829854

Niedzwiecki M, Hall MN, Liu X, Oka J, Harper K, Slavkovich V, Ilievski V, Levy D, van Geen A, Mey J, Alam S, Siddique A, Parvez F, Graziano JH, and Gamble MV. (2013) Blood glutathione redox status and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults. Epigenetics 8(7):730-8. PMCID: PMC3781192

Niedzwiecki MM, Hall MN, Liu X, Oka J, Harper K, Slavkovich V, Ilievski V, Levy D, van Geen A, Mey J, Alam S, Siddique AB, Parvez F, Graziano JH, and Gamble MV. (2013) A Dose-response study of arsenic exposure and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults. Environ Health Persp 121(11-12):1306-1312. PMCIID: PMC3855504

Additional submissions

Chervona Y, Munoz A, Hall M, Kluz T, Gamble MV, Costa M. Arsenic-contaminated drinking water deregulates human gene expression patterns in a gender-specific manner in Bangladeshi adults. (manuscript in preparation).

Hall MN, Liu X, Alam S, Slavkovich V, Ilievski V, Levy D, Siddique A, Parvez, F, Caudill M, Graziano JH and Gamble MV. Choline, betaine, and arsenic methylation in Bangladeshi adults (manuscript in preparation).

Harper K, Khan K, Hall M, Liu X, Graziano JH and Gamble MV. Arsenic exposure is not associated with urinary 8oxodG or risk for arsenic-induced skin lesions in Bangladesh J Occup Environ Med (accepted with minor revisions).

Harper KN, Liu X, Hall MN, Niedzwiecki M, Oka J, Ilievski V, Slavkovich V, Levy D, Siddique A, Graziano JH and Gamble MV. Low dose arsenic exposure is associated with sex-specific telomere length alterations in an arsenic-exposed population in Bangladesh (manuscript in preparation).

Howe CG, Niedzwiecki MM, Hall MN, Liu X, Ilievski V, Slavkovich V, Alam S, Siddique AB, Graziano JH, Gamble MV. Folate and cobalamin modify associations between s-adenosylmethionine and methylated arsenic metabolites in arsenic-exposed Bangladeshi adults. J Nutr (in revisions).

Niedzwiecki MM, Hall MN, Liu X, Slavkovich V, Ilievski V, Levy D, Alam S, Siddique AB, Parvez F, Graziano JH, and Gamble MV. Interactions of plasma glutathione redox and folate deficiency on arsenic methylation capacity in Bangladeshi adults. Am J Clin Nutr (submitted).

Peters BA, Hall MN, Liu X, Neugut YD, Pilsner JR, Levy D, Ilievski V, Slavkovich V, Islam T, Factor-Litvak P, Graziano JH, Gamble MV. Creatine, arsenic metabolism and renal function in an arsenic-exposed population in Bangladesh (manuscript in preparation).


Project 4: Arsenic, Iron, Sulfur and Organic Carbon Speciation

Bostick, B.C. Preliminary Results Characterizing Soils and Aerosols Associated with Ferroalloy Production. Tracing Sources and Identifying Soil Resuspension. My Sinai School of Medicine, New York NY. 28 June, 2013.

Mailloux, BJ, E. Trembath-Reichert, J. Cheung, M. Watson, M. Stute, G. A. Freyer, A. Ferguson, K. M. Ahmed, Md, J. Alam, B. A. Buchholz, J. Thomas, A. Layton, Y. Zheng, B. C. Bostick, A. van Geen. 2013. Advection of Surface-Derived Organic Carbon Fuels Microbial Reduction in Bangladesh Groundwater. Proc. Nat. Acad. Sci. USA 110 (14), 5331-5335.

Van Geen, A., B.C. Bostick, Pham T.K. Trang, Vi Mai Lan, Nguyen-Ngoc Mai, Phu Dao Manh, Pham Hung Viet, K. Radloff, Z. Aziz, J. L. Mey, M.O. Stahl, C.F. Harvey, P. Oates, B. Weinman, C. Stengel, F. Frei, R. Kipfer & M. Berg. 2013. Retardation of arsenic transport through a Pleistocene aquifer. Nature 501, 204–207 (12 September 2013) doi:10.1038/nature12444.

Additional submissions

Kraal, P, B. C. Bostick, C. P. Slomp, G.-J. Reichart. 2013. Spectroscopic approaches to quantify phosphorus forms of variable crystallinity in marine sediments. Soil Sci. Soc. Am. J., In Revision.

Nielsen, L. N. and B. C. Bostick.2013. Integrating Variable Aquifer Geochemistry and Sediment Properties into Models of Contaminant Retention. Appl. Geochem. Submitted.

Sun, J., S. N. Chillrud, B. J. Mailloux, M. Stute, B. C. Bostick. 2013. Magnetite Formation and Arsenic Retention Under Cyclical Redox Transformations. Environ. Sci. Technol. Submitted


Project 5: Application of enhanced mitigation methods for groundwater arsenic at US Superfund sites

Submission

Sun, J., S.N. Chillrud, B.J. Mailloux, M. Stute, B.C. Bostick. Magnetite Formation under Acidic Conditions in Arsenic Contaminated Aquifer Sediments. Environ. Sci. Technol., In preparation.


Project 6: Defining the Sustainable Uses of Low-Arsenic Aquifers in Bangladesh

Balasubramanya S, A Pfaff, L Bennear, A Tarozzi, KM Ahmed, A Schoenfeld, A van Geen, Evolution of households' responses to the groundwater arsenic crisis in Bangladesh: information on environmental health risks can have increasing behavioral impact over time. In press, Environment & Development Economics, September 2013. NIHMSID # 558341

Feighery F, BJ Mailloux, AS Ferguson, KM Ahmed, A van Geen, PJ Culligan, Transport of E. coli in aquifer sediments of Bangladesh: Implications for widespread microbial contamination of groundwater. Water Resources Research DOI: 10.1002/wrcr.20289, 2013.NIHMSID # 558342

Knappett, P.K., J. Du, P. Liu, V. Horvath, B. J. Mailloux, J. Feighery, A. van Geen, P. J. Culligan. Importance of reversible attachment in predicting E. coli transport in saturated aquifers from column experiments. Advances in Water Resources http://dx.doi.org/10.1016/j.advwatres.2013.11.005, 2013.NIHMSID # 558343

Mailloux BJ, E Trembath-Reichert, J Cheung, M Watson, M Stute, GA Freyer, AS Ferguson, KM Ahmed, MJ Alam, BA Buchholz, J Thomas, AC Layton, Y Zheng, BC Bostick, A van Geen, Advection of surface-derived organic carbon fuels microbial reduction in Bangladesh groundwater, PNAS 110: 5331-5335, 2013. PMCID 3619377

vanGeen, A, and CK Singh. Piloting a novel delivery mechanism of a critical public health service in India: arsenic testing of tube well water in the field for a fee.IGC Policy Note 13/0238, 2013.(http://www.theigc.org/project/piloting-a-novel-delivery-mechanism-of-a-c...)

vanGeen A, EB Ahmed, L Pitcher, JL Mey, H Ahsan, JH Graziano, KM Ahmed. Comparison of two blanket surveys of arsenic in tubewells conducted 12 years apart in a 25 km2 area of Bangladesh. Science of the Total Environment, accepted December 2013.NIHMSID #557871

vanGeen, BC Bostick, PTK Trang, VM Lan, NN Mai, PD Man, PH Viet, K Radloff, Z Aziz, JL Mey, MO Stahl, CF Harvey, P Oates, B Weinman, C Stengel, F Frei, R Kipfer, M Berg. Retardation of arsenic transport through a Pleistocene aquifer. Nature 501: 204–207, 2013.PMCID: PMC3772538

vanGeen A, KH Win, T Zaw, W Naing, JL Mey, B Mailloux. Confirmation of elevated arsenic levels in groundwater of Myanmar. Science of the Total Environment, accepted January 2014.NIHMSID #558340

Additional submission

Knappett, PSK, BJ Mailloux, I Choudhury, M Khan, H Michael, S Barua, DR Mondal, M Steckler, H Akter, KM Ahmed, B Bostick, C Harvey, M Shamsudduha, I Mihajlov, R Mozumder, A. van Geen. Vulnerability of intermediate and deep low-arsenic aquifers to municipal pumping in Bangladesh. Submitted to Environmental Sciences and Technology, January 2014.


Core A: Data Management Core

Every publication involving participant data has relied on the Data Management Core for datasets used for analyses.


Core B: Trace Metals Core Laboratory

Every publication listed for Projects 1, 2 and 3 has relied on the Trace Metal Core.


Core C: Biogeochemistry Core Laboratory

Balasubramanya S, A Pfaff, L Bennear, A Tarozzi, KM Ahmed, A Schoenfeld, A van Geen, Evolution of households' responses to the groundwater arsenic crisis in Bangladesh: information on environmental health risks can have increasing behavioral impact over time. In press, Environment & Development Economics, September 2013.

Mailloux BJ, E Trembath-Reichert, J Cheung, M Watson, M Stute, GA Freyer, AS Ferguson, KM Ahmed, MJ Alam, BA Buchholz, J Thomas, AC Layton, Y Zheng, BC Bostick, A van Geen, Advection of surface-derived organic carbon fuels microbial reduction in Bangladesh groundwater, PNAS 110: 5331-5335, 2013.

vanGeen, BC Bostick, PTK Trang, VM Lan, NN Mai, PD Man, PH Viet, K Radloff, Z Aziz, JL Mey, MO Stahl, CF Harvey, P Oates, B Weinman, C Stengel, F Frei, R Kipfer, M Berg. Retardation of arsenic transport through a Pleistocene aquifer. Nature 501: 204–207, 2013.

Additional submissions

vanGeen A, EB Ahmed, L Pitcher, JL Mey, H Ahsan, JH Graziano, KM Ahmed. Comparison of two blanket surveys of arsenic in tubewells conducted 12 years apart in a 25 km2 area of Bangladesh. Science of the Total Environment, accepted December 2013.

vanGeen A, KH Win, T Zaw, W Naing, JL Mey, B Mailloux. Confirmation of elevated arsenic levels in groundwater of Myanmar. Science of the Total Environment, accepted January 2014.


Core D: Hydrogeology Support Laboratory

Knappett, P.K., J. Du, P. Liu, V. Horvath, B. J. Mailloux, J. Feighery, A. van Geen, P. J. Culligan. Importance of reversible attachment in predicting E. coli transport in saturated aquifers from column experiments. Advances in Water Resources http://dx.doi.org/10.1016/j.advwatres.2013.11.005, 2013.

Additional submissions

Knappett, PSK, BJ Mailloux, I Choudhury, M Khan, H Michael, S Barua, DR Mondal, M Steckler, H Akter, KM Ahmed, B Bostick, C Harvey, M Shamsudduha, I Mihajlov, R Mozumder, A. van Geen. Vulnerability of intermediate and deep low-arsenic aquifers to municipal pumping in Bangladesh. Submitted to Environmental Sciences and Technology, January 2014.

Stahl, MO, JB Ong, CF Harvey, CD Johnson, ABM Badruzzaman, MH Tarek, A. van Geen, JA Anderson, JW Lane. Well-casing leak detection: Applications of fluid replacement logging in arsenic-contaminated aquifers of Bangladesh. Revision submitted to Groundwater, September 2013.


Core E: Community Engagement Core

Submissions

Flanagan, S.V., R.G. Marvinney, and Y. Zheng (2013a).Influences on domestic well water testing behavior in a Central Maine area with frequent groundwater arsenic occurrence. Science of the Total Environment, submitted.

Flanagan, S.V., R.G. Marvinney, C.W. Culbertson, and Y. Zheng (2013b). Dissemination of well water arsenic results to homeowners in Central Maine: Influences on mitigation behavior and continued risks for exposure. Science of the Total Environment, submitted.

Research Translation Core

: No peer-reviewed publications


2012 Publications

2012 Annual Project and Core Updates (pdf)

All Projects and Cores

(*-denotes publications that resulted from collaborations between project and core activities)

Argos M, Ahsan H, Graziano JH. Arsenic and human health: epidemiologic progress and public health implications. Rev Environ Health. 2012;doi:10.1515/reveh-2012-0021. PMCID: In progress.

Arita A, Shamy MY, Chervona Y, Clancy HA, Sun H, Hall MN, Qu Q, Gamble MV, Costa M. The effect of exposure to carcinogenic metals on histone tail modifications and gene expression in human subjects. J Trace Elem Med Biol 2012;26:174-8. PMID: 22633395 doi: 10.1016/j.jtemb.2012.03.012

Bennear L, Tarozzi A, Pfaff A, Soumya HB, Ahmed KM, van Geen A. Impacts of a randomized controlled trial in arsenic risk communication on household water supply choices in Bangladesh, J Environ Econ Manage, 2012; in press.

Clancy HA, Sun H, Passantino L, Kluz T, Muñoz A, Zavadil J and Costa M. Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer. Metallomics 2012;4(8):784-93. PMID: 22714537 doi: 10.1039/c2mt20074k

Chen Y, McClintock TR, Segers S, Parvez F, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Ahsan H. Prospective investigation of major dietary patterns and risk of cardiovascular mortality in Bangladesh. Int J Cardiol. 2012;doi.org/10.1016/j.ijcard.2012.04.041. PMCID: In progress.

*Chervona Y, Hall MN, Arita A, Wu F, Sun H, Tseng HC, Ali E, Uddin MN, Liu X, Zoroddu MA, Gamble MV*, Costa M. Association Between Arsenic Exposure and Global Post-translational Histone Modifications Among Adults in Bangladesh. Cancer Epidemiol Biomarkers Prev. 2012;12:2252-60. doi: 10.1158/1055-9965. PMCID: PMC3518638

Chervona Y, Costa M. The control of histone methylation and gene expression by oxidative stress, hypoxia and metals. Free Radic Biol Med 2012;53(5):1041-7. PMCID: PMC3432141

*Ferguson AS, Layton AC, Mailloux BJ, Culligan PJ, Williams DE, Smartt AE, Feighery J, McKay L, Knappett P, Alexandrova E, Arbit T, Emch M, Escamilla V, Ahmed KM, Alam MJ, Streatfield PK, Yunus M, van Geen A. Comparison of fecal indicators with pathogenic bacteria and rotavirus in groundwater, Sci Total Environ, 2012;431:314–22. PMID: 22705866 NIHMS387725

Gamble MV and Hall MN. Relationship of nutrition and urinary creatinine with arsenic metabolism. Commentary. Environ Health Perspect. 2012;120(4):A145-6. PMCID: PMC3339472

*George CM, Zheng Y, Graziano JH, Rasul SB, Mey JL, van Geen A. Evaluation of an arsenic test kit for rapid well screening in Bangladesh, Environ Sci Technol 2012;46:11213–9. PMID: 22866936

*George CM, Khan K, Islam T, Singha A, Moon-Howard J, Factor-Litvak P, van Geen A, Graziano JH. Approaches to increase arsenic awareness in Bangladesh: An evaluation of an arsenic education program. Health Educ Behav. 2012;Sep 14. [Epub ahead of print] doi: 10.1177/1090198112454735, PMID: 22984214

*George CM, van Geen A, Slavkovich V, Singha A, Levy D, Islam T, Ahmed KM, Moon-Howard J, Tarozzi A, Liu X, Factor-Litvak P, Graziano JH. A cluster-based randomized controlled trial promoting community participation in arsenic mitigation efforts in Bangladesh. Environ Health. 2012;11:41. doi: 10.1186/1476-069X-11-41. PMCID: PMC3506475

*George CM, Graziano JH, Mey JL, van Geen A. Impact on arsenic exposure of a growing proportion of untested wells in Bangladesh, Environ Health 2012;11:7. doi: 10.1186/1476-069X-11-7. PMCID: PMC3334680

Hall MN, Gamble MV. Nutritional manipulation of one-carbon metabolism: effects on arsenic methylation and toxicity. J Toxicol 2012;2012:595307. PMCID: PMC3317163

*Khan K, Wasserman GA, Liu X, Ahmed E, Parvez F, Slavkovich V, Levy D, Mey J, van Geen A, Graziano JH, Factor-Litvak P. Manganese exposure from drinking water and children’s academic achievement, NeuroToxicology 2012;33:91-7. PMCID: PMC3282923

*Knappett PSK, LD McKay, A Layton, DE Williams, MJ Alam, MR Huq, J Mey, JE Feighery, PJ Culligan, BJ Mailloux, J Zhuang, V Escamilla, M Emch, E Perfect, GS Sayler, KM Ahmed, A van Geen, Implications of fecal bacteria input from latrine-polluted ponds for wells in sandy aquifers, Environ Sci Technology 2012;46: 1361–70. PMID: 22191430 NIHMS349773 doi: 10.1021/es202773w

*Knappett P, McKay LD, Layton A, Williams DE, Alam MJ, Mailloux BJ, Ferguson AS, Culligan PJ, Serre ML, Emch M, Ahmed KM, Sayler GS, van Geen A. Unsealed tubewells lead to increased fecal contamination of drinking water. J Water Health 2012;10(4):565-78. doi: 10.2166/wh.2012.102. PMID: 23165714

*Mailloux BJ, Trembath-Reichert E, Cheung J, Watson M, Stute M, Freyer GA, Ferguson AS, Ahmed KM, Alam MJ, Buchholz BA, Thomas J, Layton AC, Zheng Y, Bostick BC, van Geen A. Advection of surface-derived organic carbon fuels microbial reduction in Bangladesh groundwater. PNAS, 2013; in press.

Melkonian S, Argos M, Chen Y, Parvez F, Pierce B, Ahmed A, Islam T, Ahsan H. Intakes of several nutrients are associated with incidence of arsenic-related keratotic skin lesions in Bangladesh. J Nutr. 2012;142(12):2128-34. PMCID: PMC3497963.

Morain, SA and AM Budge,eds. International Society for Photogrammetry and Remote Sensing (ISPRS) Book Series: Environmental Tracking For Public Health Surveillance, Chapter 6 Data discovery, access and retrieval contributions by ML Golden on “Populations near Superfund Sites”. 2012. London: CRC Press,Taylor & Francis Group. Print ISBN: 978-0-415-58471-5. eBook ISBN: 978-0-203-09327-6. http://dx.doi.org/10.1201/b12680

Pesola GR, Parvez F, Chen Y, Ahmed A, Hasan R, Ahsan H. Arsenic exposure from drinking water and dyspnoea risk in Araihazar, Bangladesh: a population-based study. Eur Respir J. 2012;39(5):1076-83. PMCID: In progress.

Pierce BL, Kibriya MG, Tong L, Jasmine F, Argos M, Roy S, Paul-Brutus R, Rahaman R, Rakibuz-Zaman M, Parvez F, Ahmed A, Quasem I, Hore SK, Alam S, Islam T, Slavkovich V, Gamble MV, Yunus M, Rahman M, Baron JA, Graziano JH, Ahsan H. Genome-wide association study identifies chromosome 10q24.32 variants associated with arsenic metabolism and toxicity phenotypes in Bangladesh. PLoS Genet 2012;8:e1002522. PMCID: PMC3285587

Pilsner JR, Hall MN, Liu X, Ilievski V, Slavkovich V, Levy D, Factor-Litvak P, Yunus M, Rahman M, Graziano JH, Gamble MV. Influence of prenatal arsenic exposure and newborn sex on global methylation of cord blood DNA. PLoS One 2012;7:e37147. PMCID: PMC3360698

Syed EH, Melkonian S, Poudel KC, Yasuoka J, Otsuka K, Ahmed A, Islam T, Parvez F, Slavkovich V, Graziano JH, Ahsan H, Jimba M. Arsenic Exposure and Oral Cavity Lesions in Bangladesh. J Occup Environ Med. 2013;55(1):59-66. PMCID: In progress.

Wovkulich, K, Mailloux BJ, Bostick BC, Dong H, Bishop ME, Chillrud SN. Use of Microfocused X-ray Techniques to Investigate Mobilization of Arsenic by Oxalic Acid. Geochim Cosmo Acta, 2012;91:254-70. PMCID: PMC3501129

*Wu F, Jasmine, F, Kibriya MG, Liu ML, Wojcik O, Parvez F, Rahaman R, Roy S, Paul-Brutus R, Segers S, Slavkovich V, Islam T, Levy D, Mey JL, van Geen A, Graziano JH, Ahsan H, Chen Y. Association between arsenic exposure from drinking water and plasma levels of cardiovascular markers, Am J Epidemiol 2012;175(12):1252-61. PMCID: PMC3372314


Project 1: A Cohort Study of Health Effects of Arsenic Exposure in Bangladesh

Argos M, Ahsan H, Graziano JH. Arsenic and human health: epidemiologic progress and public health implications. Rev Environ Health: Volume 27, Issue 4, Pages 191–195, ISSN (Online) 2191-0308, ISSN (Print) 0048-7554, DOI: 10.1515/reveh-2012-0021, September 2012.

Chen Y, McClintock TR, Segers S, Parvez F, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Ahsan H. Prospective investigation of major dietary patterns and risk of cardiovascular mortality in Bangladesh. Int J Cardiol. 2012;dx.doi.org/10.1016/j.ijcard.2012.04.041. PMCID: In progress.

Chen Y, Wu F, Liu M, Parvez F, Slavkovich V, Eunus M, Ahmed A, Segers S, Argos M, Islam T, Rakibuz-Zaman M, Hasan R, Sarwar G, Levy D, Graziano J, Ahsan H. A Prospective Study of Arsenic Exposure, Arsenic Methylation Capacity, and Risk of Cardiovascular Disease in Bangladesh. Environmental Health Perspectives (tba). doi:10.1289/ehp.1205797 Online publication: May 10, 2013.

Chen Y, Wu F, Parvez F, Ahmed A, Eunus M, McClintock TR, Patwary TI, Islam T, Ghosal AK, Islam S, Hasan R, Levy D, Sarwar G, Slavkovich V, van Geen A, Graziano JH, Ahsan H. Arsenic Exposure from Drinking Water and QT-Interval Prolongation: Results from the Health Effects of Arsenic Longitudinal Study. Environ Health Perspect 121:427-432 (2013). http://dx.doi.org/10.1289/ehp.1205197 [online 05 February 2013]

Melkonian S, Argos M, Chen Y, Parvez F, Pierce B, Ahmed A, Islam T, Ahsan H. Intakes of several nutrients are associated with incidence of arsenic-related keratotic skin lesions in Bangladesh. J Nutr. 2012;142(12):2128-34. PMCID: PMC3497963

Pierce BL, Kibriya MG, Tong L, Jasmine F, Argos M, Roy S, Paul-Brutus R, Rahaman R, Rakibuz-Zaman M, Parvez F, Ahmed A, Quasem I, Hore SK, Alam S, Islam T, Slavkovich V, Gamble MV, Yunus M, Rahman M, Baron JA, Graziano JH, Ahsan H. Genome-wide association study identifies chromosome 10q24.32 variants associated with arsenic metabolism and toxicity phenotypes in Bangladesh. PLoS Genet. 2012;8(2):e1002522. PMCID: PMC3285587.

Pesola GR, Parvez F, Chen Y, Ahmed A, Hasan R, Ahsan H. Arsenic exposure from drinking water and dyspnoea risk in Araihazar, Bangladesh: a population-based study. Eur Respir J. 2012; 39(5):1076-83. doi: 10.1183/09031936.00042611. Epub 2011 Nov 16. PMCID: In progress.

Syed EH, Melkonian S, Poudel KC, Yasuoka J, Otsuka K, Ahmed A, Islam T, Parvez F, Slavkovich V, Graziano JH, Ahsan H, Jimba M. Arsenic Exposure and Oral Cavity Lesions in Bangladesh. J Occup Environ Med. 2013;55(1):59-66. doi: 10.1097/JOM.0b013e31826bb686. PMCID: In progress.

Wu F, Jasmine F, Kibriya MG, Liu M, Wójcik O, Parvez F, Rahaman R, Roy S, Paul-Brutus R, Segers S, Slavkovich V, Islam T, Levy D, Mey JL, van Geen A, Graziano JH, Ahsan H, Chen Y. Association between arsenic exposure from drinking water and plasma levels of cardiovascular markers. Am J Epidemiol. 2012;175(12):1252-61. PMCID: PMC3372314.


Project 2: Consequences of Arsenic and Manganese Exposure on Children

Submission

Wasserman G, Liu X, Kline J, Factor-Litvak P, LoIacono N, van Geen A, Mey J, Levy D, Abramson R, Schwartz, A, Graziano, JH.Exposure to arsenic from household wells and intelligence, in Maine schoolchildren. Environ Health Perspect, in review, 2013.


Project 3: Impact of nutrition on arsenic-induced epigenetic dysregulation

Arita A, Shamy MY, Chervona Y, Clancy HA, Sun H, Hall MN, Qu Q, Gamble MV, Costa M. The effect of exposure to carcinogenic metals on histone tail modifications and gene expression in human subjects. J Trace Elem Med Biol 2012;26:174-8. PMID: 22633395 doi: 10.1016/j.jtemb.2012.03.012

Chervona Y, Costa M. The control of histone methylation and gene expression by oxidative stress, hypoxia and metals. Free Radic Biol Med 2012;53(5):1041-7. PMCID: PMC3432141

Chervona Y, Hall MN, Arita A, Wu F, Sun H, Tseng HC, Ali E, Uddin MN, Liu X, Zoroddu MA, Gamble MV*, Costa M*. Association Between Arsenic Exposure and Global Post-translational Histone Modifications Among Adults in Bangladesh. Cancer Epidemiol Biomarkers Prev. 2012;12:2252-60. doi: 10.1158/1055-9965. PMCID: PMC3518638

Clancy, HA, Sun H, Passantino L, Kluz T, Muñoz A, Zavadil J and Costa M. Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer. Metallomics 2012;4(8):784-93. PMID: 22714537 doi: 10.1039/c2mt20074k

Gamble MV and Hall MN. Relationship of nutrition and urinary creatinine with arsenic metabolism. Commentary. Environ Health Perspect. 2012;120(4):A145-6. PMCID: PMC3339472

Hall MN, Gamble MV. Nutritional manipulation of one-carbon metabolism: effects on arsenic methylation and toxicity. J Toxicol 2012;2012:595307. PMCID: PMC3317163

Hall MN, Niedzwiecki M, Liu X, Harper KN, Alam S, Slavkovich V, Ilievski V, Levy D, Siddique S, Parvez F, Mey JL, van Geen A, Graziano J, and Gamble MV. Chronic Arsenic Exposure and Blood Glutathione and Glutathione Disulfide Concentrations in Bangladeshi Adults. Environmental Health Perspectives http://dx.doi.org/10.1289/ehp.1205727 . Advance Publication: 21 June 2013.

Harper KN, Peters BA, Gamble MV. In Press. Batch Effects and pathway analysis: Two potential perils in cancer studies involving DNA methylation array analysis. Cancer Epidemiol Biomarkers Prev 2013; 22(6); 1–9. Published OnlineFirst April 29, 2013; doi:10.1158/1055-9965.EPI-13-0114.

Niedzwiecki M, Hall MN, Liu X, Oka J, Harper KN, Slavkovich V, Ilievski V, Levy D, van Geen A, Mey JL, Alam S, Siddique AB, Parvez F, Graziano JH, and Gamble MV. Blood glutathione redox status and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults. Landes Bioscience 2013:8(7):730-738. http://dx.doi.org/10.4161/epi.25012. Published Online: May 17, 2013.

Pilsner JR, Hall MN, Liu X, Ilievski V, Slavkovich V, Levy D, Factor-Litvak P, Yunus M, Rahman M, Graziano JH, Gamble MV. Influence of prenatal arsenic exposure and newborn sex on global methylation of cord blood DNA. PLoS One 2012;7:e37147. PMCID: PMC3360698

Pierce BL, Kibriya MG, Tong L, Jasmine F, Argos M, Roy S, Paul-Brutus R, Rahaman R, Rakibuz-Zaman M, Parvez F, Ahmed A, Quasem I, Hore SK, Alam S, Islam T, Slavkovich V, Gamble MV, Yunus M, Rahman M, Baron JA, Graziano JH, Ahsan H. Genome-wide association study identifies chromosome 10q24.32 variants associated with arsenic metabolism and toxicity phenotypes in Bangladesh. PLoS Genet 2012;8:e1002522. PMCID: PMC3285587

Additional submission

Harper KN, Hall MN, Liu X, Ilievski V, Oka J, Calancie L, Slavkovich V, Levy D, Mey JL, van Geen L, Graziano JH and Gamble MV. (2013) Arsenic and oxidative damage: A dose-response study of drinking water arsenic exposure in humans. Amer J Occup and Env Med (in review).


Project 4: Arsenic, Iron, Sulfur and Organic Carbon Speciation

Wovkulich, K, B.J. Mailloux, B.C. Bostick, H. Dong, M.E. Bishop, S.N. Chillrud. Use of Microfocused X-ray Techniques to Investigate Mobilization of Arsenic by Oxalic Acid. Geochim Cosmo Acta, 2012;91:254-70. PMCID: PMC3501129

Additional Submissions

Mailloux, BJ, E. Trembath-Reichert, J. Cheung, M. Watson, M. Stute, G. A. Freyer, A. Ferguson, K. M. Ahmed, Md, J. Alam, B. A. Buchholz, Y. Zheng, B. C. Bostick, A. van Geen. 2012. Advection of Surface-Derived Organic Carbon Fuels Microbial Reduction in Bangladesh Groundwater. Proc. Nat. Acad. Sci. USA, 2013; in press.

Nielsen, L. N. and B. C. Bostick. Integrating Variable Aquifer Geochemistry and Sediment Properties into Models of Contaminant Retention. Appl. Geochem. Submitted 2012.

Quicksall A.N. and B. C. Bostick. 2012. Variable Rates of Microbially-Mediated Iron and Sulfate Reduction: Impact on Aqueous Arsenic Levels. Geochim. Cosmochim. Acta. Submitted.

Sun, J., S.N. Chillrud, B.J. Mailloux, M. Stute, B.C. Bostick. Magnetite Formation under Acidic Conditions in Arsenic Contaminated Aquifer Sediments. Environ. Sci. Technol., Submitted, 2012.


Project 5: Application of enhanced mitigation methods for groundwater arsenic at US Superfund sites

Wovkulich, K, Mailloux BJ, Bostick BC, Dong H, Bishop ME, Chillrud SN. Use of Microfocused X-ray Techniques to Investigate Mobilization of Arsenic by Oxalic Acid. Geochim Cosmo Acta, 2012;91:254-70. PMCID: PMC3501129

Additional submission

Sun, J., S.N. Chillrud, B.J. Mailloux, M. Stute and B.C. Bostick. Magnetite Formation under Acidic Conditions in Arsenic Contaminated Aquifer Sediments. Environ. Sci. & Technol., Submitted, 2012.


Project 6: Defining the Sustainable Uses of Low-Arsenic Aquifers in Bangladesh

Ferguson AS, AC Layton, BJ Mailloux, PJ Culligan, DE Williams, AE Smartt, J Feighery, L McKay, P Knappett, E Alexandrova, T Arbit, M Emch, V Escamilla, KM Ahmed, MJ Alam, PK Streatfield, M Yunus, A van Geen, Comparison of fecal indicators with pathogenic bacteria and rotavirus in groundwater, Sci Total Environ, 2012;431:314–22. PMID: 22705866 NIHMS387725

George CM, Graziano JH, Mey JL, van Geen A, Impact on arsenic exposure of a growing proportion of untested wells in Bangladesh, Environ Health 2012;11:7. doi: 10.1186/1476-069X-11-7. PMCID: PMC3334680

George CM, Khan K, Islam T, Singha A, Moon-Howard J, Factor-Litvak P, van Geen A, Graziano JH. Approaches to increase arsenic awareness in Bangladesh: An evaluation of an arsenic education program. Health Educ Behav. 2012;Sep 14. [Epub ahead of print] doi: 10.1177/1090198112454735, PMID: 22984214

George CM, van Geen A, Slavkovich V, Singha A, Levy D, Islam T, Ahmed KM, Moon-Howard J, Tarozzi A, Liu X, Factor-Litvak P, Graziano A cluster-based randomized controlled trial promoting community participation in arsenic mitigation efforts in Bangladesh. Environ Health. 2012;11:41. doi: 10.1186/1476-069X-11-41. PMCID: PMC3506475

George CM, Zheng Y, Graziano JH, Rasul SB, Mey JL, van Geen A. Evaluation of an arsenic test kit for rapid well screening in Bangladesh, Environ Sci Technol 2012;46:11213–9. PMID: 22866936

Khan K, Wasserman GA, Liu X, Ahmed E, Parvez F, Slavkovich V, Levy D, Mey J, van Geen A, Graziano JH, Factor-Litvak P. Manganese exposure from drinking water and children’s academic achievement, NeuroToxicology 2012;33:91-7. PMCID: PMC3282923

Knappett PSK, LD McKay, A Layton, DE Williams, MJ Alam, MR Huq, J Mey, JE Feighery, PJ Culligan, BJ Mailloux, J Zhuang, V Escamilla, M Emch, E Perfect, GS Sayler, KM Ahmed, A van Geen, Implications of fecal bacteria input from latrine-polluted ponds for wells in sandy aquifers, Environ Sci Technology 2012;46: 1361–70. PMID: 22191430 NIHMS349773 doi: 10.1021/es202773w

Knappett P, McKay LD, Layton A, Williams DE, Alam MJ, Mailloux BJ, Ferguson AS, Culligan PJ, Serre ML, Emch M, Ahmed KM, Sayler GS, van Geen A. Unsealed tubewells lead to increased fecal contamination of drinking water. J Water Health 2012;10(4):565-78. doi: 10.2166/wh.2012.102. PMID: 23165714

Wu F, Jasmine F, Kibriya MG, Liu ML, Wojcik O, Parvez F, Rahaman R, Roy S, Paul-Brutus R, Segers S, Slavkovich V, Islam T, Levy D, Mey JL, van Geen A, Graziano JH, Ahsan H, Chen Y. Association between arsenic exposure from drinking water and plasma levels of cardiovascular markers, Am J Epidemiol 2012;175:1252-61. PMCID: PMC3372314

Additional submissions

Bennear L, Tarozzi A, Pfaff A, Soumya HB, Ahmed KM, van Geen A. Impacts of a randomized controlled trial in arsenic risk communication on household water supply choices in Bangladesh, J Environ Econ Manage, 2012;in press

Feighery J, BJ Mailloux, AS Ferguson, KM Ahmed, A van Geen, PJ Culligan, Transport of E. coli in aquifer sediments of Bangladesh: Implications for widespread microbial contamination of groundwater. Water Resources Res, under revision January 2012.

Mailloux BJ, Trembath-Reichert E, Cheung J, Watson M, Stute M, Freyer GA, Ferguson AS, Ahmed KM, Alam MJ, Buchholz BA, Thomas J, Layton AC, Zheng Y, Bostick BC, van Geen A. Advection of surface-derived organic carbon fuels microbial reduction in Bangladesh groundwater. PNAS, 2013; in press.

van Geen, BC Bostick, PTK Trang, VM Lan, NN Mai, PD Man, PH Viet, K Radloff, Z Aziz, JL Mey, MO Stahl, CF Harvey, P Oates, B Weinman, C Stengel, F Frei, R Kipfer, M Berg, Delayed contamination of an aquifer with high-arsenic groundwater drawn by the municipal supply of Hanoi, Vietnam, Nature, submitted December 2012.


Core A: Data Management Core

Every publication involving participant data has relied on the Data Management Core for datasets used for analyses.


Core B: Trace Metals Core Laboratory

Every publication listed for Projects 2, 3 and 4 has relied on the Trace Metal Core.


Core C: Biogeochemistry Core Laboratory

George CM, Graziano JH, Mey JL, van Geen A, Impact on arsenic exposure of a growing proportion of untested wells in Bangladesh, Environ Health 2012;11:7. doi: 10.1186/1476-069X-11-7. PMCID: PMC3334680

George CM, Zheng Y, Graziano JH, Rasul SB, Mey JL, van Geen A. Evaluation of an arsenic test kit for rapid well screening in Bangladesh. Environ Sci Technol 2012;46:11213–9. PMID: 22866936

Khan K, Wasserman GA, Liu X, Ahmed E, Parvez F, Slavkovich V, Levy D, Mey J, van Geen A, Graziano JH, Factor-Litvak P. Manganese exposure from drinking water and children’s academic achievement, NeuroToxicology 2012;33:91-7. PMCID: PMC3282923

Wovkulich, K, Mailloux BJ, Bostick BC, Chillrud SN. Use of microfocused x-ray techniques to investigate mobilization of Arsenic by Oxalic Acid. Geochim. Cosmo. Acta, 2012;91:254-70. PMCID: PMC3501129

Wu F, Jasmine, F, Kibriya MG, Liu ML, Wojcik O, Parvez F, Rahaman R, Roy S, Paul-Brutus R, Segers S, Slavkovich V, Islam T, Levy D, Mey JL, van Geen A, Graziano JH, Ahsan H, Chen Y. Association between arsenic exposure from drinking water and plasma levels of cardiovascular markers, Am J Epidemiol 2012;175:1252-61. PMCID: PMC3372314

Additional Submission

van Geen, BC Bostick, PTK Trang, VM Lan, NN Mai, PD Man, PH Viet, K Radloff, Z Aziz, JL Mey, MO Stahl, CF Harvey, P Oates, B Weinman, C Stengel, F Frei, R Kipfer, M Berg, Delayed contamination of an aquifer with high-arsenic groundwater drawn by the municipal supply of Hanoi, Vietnam, Nature, sent out for review December 2012.


Core D: Hydrogeology Support Laboratory

Knappett PSK, LD McKay, A Layton, DE Williams, MJ Alam, MR Huq, J Mey, JE Feighery, PJ Culligan, BJ Mailloux, J Zhuang, V Escamilla, M Emch, E Perfect, GS Sayler, KM Ahmed, A van Geen, Implications of fecal bacteria input from latrine-polluted ponds for wells in sandy aquifers, Environ Sci Technol 2012;46:1361–70. PMID: 22191430 NIHMS349773

Knappett P, LD McKay, A Layton, DE Williams, MJ Alam, BJ Mailloux, AS Ferguson, PJ Culligan, ML Serre, M Emch, KM Ahmed, GS Sayler, A van Geen, Unsealed tubewells lead to increased fecal contamination of drinking water, J Water Health 2012;10(4):565-78. PMID: 23165714

Additional Submission

van Geen, BC Bostick, PTK Trang, VM Lan, NN Mai, PD Man, PH Viet, K Radloff, Z Aziz, JL Mey, MO Stahl, CF Harvey, P Oates, B Weinman, C Stengel, F Frei, R Kipfer, M Berg, Delayed contamination of an aquifer with high-arsenic groundwater drawn by the municipal supply of Hanoi, Vietnam, Nature, sent out for review December 2012.


Core E: Community Engagement Core

No peer-reviewed publications


Research Translation Core

Morain, SA and AM Budge,eds. International Society for Photogrammetry and Remote Sensing (ISPRS) Book Series: Environmental Tracking For Public Health Surveillance, Chapter 6 Data discovery, access and retrieval contributions by ML Golden on “Populations near Superfund Sites”. 2012. London: CRC Press,Taylor & Francis Group. Print ISBN: 978-0-415-58471-5. eBook ISBN: 978-0-203-09327-6. http://dx.doi.org/10.1201/b12680


2011 Publications

Project 1: Genotoxic and Cell Signaling Pathways of Arsenic in Mammalian Cells

Huang, S.X., Jaurand, M. C., Kamp, D. W., Whysner, J., and Hei, T.K. Role of mutagenicity in asbestos fiber induced carcinogenicity and other diseases.  J. Toxicol. Environ. Hlth. B Crit Rev 2011;14:179-245. PMCID: PMC3118525

Ivanov,V., and Hei, T.K.  Regulation of apoptosis in human melanoma and neuroblastoma cells by statins, sodium arsenite and TRAIL: a role of combined treatment versus monotherpy.  Apoptosis: 16:1268-1284, 2011. PMID: 21910007 PMCID: in process.

Ivanov, V., Partridge, M.A., Huang, S.X., and Hei, T.K. Suppression of the proinflammatory response of metastatic melanoma cells increases TRAIL induced apoptosis. J. Cell Biochem. 112(2):463-75, 2011. PMID: 21268068. doi: 10.1002/jcb.22934.

Wen, G., Hong, M., Li, B., Liao, W., Cheng, S.K., Hu, B., Calaf, G., Partridge, M.A., Tong, J., and Hei, T.K., Transforming growth factor-B induced protein (TGFBI) suppresses mesothelioma progression through the AKT/mTOR pathway.  Int. J. Oncology 2011;39(4):1001-9, 2011. doi: 10.3892/ijo.2011 PMCID: in process.


Project 2:  A Cohort Study of Health Effects of Arsenic Exposure in Bangladesh

Argos M, Kalra T, Rathouz PJ, Chen Y, Pierce B, Islam T, Ahmed A, Hassan R, Parvez F, Graziano J, Ahsan H. A Prospective Study of Arsenic Exposure from Drinking Water and Incidence of Skin Lesions in Bangladesh. Amer J Epidemiol 2011;174(2):185-94. PMCID: PMC3167679

Chen Y, Graziano JH, Parvez F, Liu M, Slavkovich V, Kalra T, Argos M, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Levy D, van Geen A, Ahsan H. Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort study.  BMJ. 2011;5:342:d2431. PMCID: PMC3088786

Chen Y, Parvez F, Liu M, Pesola GR, Gamble MV, Slavkovich V, Islam T, Ahmed A, Hasan R, Graziano JH, Ahsan H. “Association between arsenic exposure from drinking water and proteinuria: results from the Health Effects of Arsenic Longitudinal Study”. Int J Epidemiol. 2011;40(3):828-35. PMCID: PMC3147073

Louis ED, Hafeman D, Parvez F, Alcalay RN, Islam T, Siddique AB, Patwary TI, Melkonian S, Argos M, Levy D, Ahsan H. Prevalence of essential tremor in Araihazar, Bangladesh: a population-based study. Neuroepidemiology. 2011;36(2):71-6. Epub 2011 Jan 19. PMCID: PMC3047762.

Louis ED, Hafeman D, Parvez F, Liu X, Alcalay RN, Islam T, Ahmed A, Siddique AB, Patwary    TI, Melkonian S, Argos M, Levy D, Ahsan H. Tremor severity and age: A cross-sectional, population-based study of 2,524 young and midlife normal adults. Mov Disord. 2011;26(8):1515-20. doi: 10.1002/mds.23674. Epub 2011 Mar 25. PMID: 21442657. PMCID: in process.

Melkonian S, Argos M, Pierce BL, Chen Y, Islam T, Ahmed A, Syed EH, Parvez F, Graziano J, Rathouz PJ, Ahsan H. A Prospective Study of the Synergistic Effects of Arsenic Exposure and Smoking, Sun Exposure, Fertilizer Use, and Pesticide Use on Risk of Premalignant Skin Lesions in Bangladeshi Men. Amer J Epidemiol 2011;173(2):183-91 PMCID: PMC3011951

Parvez F, Chen Y, Brandt-Rauf PW, Slavkovich V, Islam T, Ahmed A, Argos M, Hassan R, Yunus M, Haque SE, Balac O, Graziano JH, Ahsan H. A prospective study of respiratory symptoms associated with chronic arsenic exposure in Bangladesh: findings from the Health Effects of Arsenic Longitudinal Study (HEALS). Thorax. 2010; 65(6):528-33. PMID: 20522851.

Pierce BL, Kalra T, Argos M, Parvez F, Chen Y, Islam T, Ahmed A, Hasan R, Rakibuz-Zaman M, Graziano J, Rathouz PJ, Ahsan H. A prospective study of body mass index and mortality in Bangladesh. Int J Epidemiol. 2010; 39(4): 1037-45. PMCID: PMC2929350. Pierce BL, Argos M, Chen Y, Melkonian S, Parvez F, Islam T, Ahmed A, Hasan R, Rathouz PJ, Ahsan H. Arsenic exposure, dietary patterns, and skin lesion risk in Bangladesh: A prospective study. Am J Epidemiol. 2011 Feb 1;173(3):345-54. PMCID: PMC3105269.

Wu Fen, Jasmine F, Kibriya MG, Liu M, Wóojcik O, Parvez F, Roy S, Rahaman R, Segers S, Slavkovich V, Islam T, Levy D, van Geen A, Graziano J, Ahsan H,  and Chen Y.  Association between arsenic exposure from drinking water and serum levels of cardiovascular markers. Amer J Epidemiol.  In press, 2011.


Project 3:  Consequences of Arsenic and Manganese Exposure on Childhood Intelligence

George, CM, van Geen, A, Slavkovich, V, Singha, A, Levy, D, Islam, T, Ahmed, KM, Moon-Howard, J, Tarozzi, A, Liu, X, Factor-Litvak, P, Graziano, J:  A cluster-based randomized controlled trial promoting community participation in arsenic mitigation efforts in Singair, Bangladesh.  Submitted.

Khan, K, Factor-Litvak, P, Wasserman, GA, Liu, X, Ahmed, E, Parvez, F, Slavkovich, V, Levy, D, Mey, J, van Geen, A, Graziano, JG:  Manganese exposure from drinking water and children’s classroom behavior in Bangladesh.  Environ Health Perspect 2011;119:1501-6.  PMID:  21493178. PMCID: in process.

Khan, K, Wasserman, G, Liu, X, Ahmed, E, Parvez, F, Slavkovic, V, Levy, D, Mey, J, van Geen, A, Graziano, J, Factor-Litvak, P:  Manganese exposure from drinking water and children’s academic achievement.  Neurotoxicology, in press, 2011.

Parvez, F, Wasserman, GA, Factor-Litvak, P, Liu, X, Ahsan, H, Slavkovich, V, Sultana, Re, Sultana, Ru, Levy, D, Kline, J, Siddique, A, Islam, T, Graziano, JH:  Arsenic exposure and motor function among children in Bangladesh.    Environ Health Perspect, 2011;119(11):1665-70. PMID: 21742576 PMCID: in process.

Wasserman, GA, Liu, X, Parvez, F, Factor-Litvak, P, Ahsan, H, Levy, D, Kline, J, van Geen, A, Mey, J, Slavkovich, V, Siddique, A, Islam, T, Graziano, JH:  Arsenic and manganese exposure and children’s intellectual function.  Neurotoxicology 2011;32:450-7. PMID:  21453714. PMCID: in process.


Project 4: One-Carbon Metabolism, Oxidative Stress and Arsenic Toxicity in Bangladesh

Chen Y, Parvez F, Liu M, Pesola GR, Gamble MV, Slavkovich V, Islam T, Ahmed A, Hasan R, Graziano JH, and Ahsan H. (2011). Association between arsenic exposure from drinking water and proteinuria: results from the Health Effects of Arsenic Longitudinal Study. Int J Epidemiol 2011;40:828-35. PMCID: PMC3147073.

Gonda TA, Takaishi S, Salas MC, Kim Y, Gamble MV, Shibata W, Muthupalani S, Abrams J, Fox JG, Wang TC, Tycko B.  Folic acid increases global DNA methylation and reduces inflammation to prevent Helicobacter associated gastric cancer in mice.  Gastroenterology, 2011; in press.

Lawley SD, Cinderella M, Hall MN, Gamble MV, Nijhout HF, and Reed MC. Mathematical model insights into arsenic detoxification. Theor Biol Med Model. 2011;8:31. PMCID: PMC3224592

Pilsner JR, Hall MN, Liu X, Ahsan H, Ilievski V, Slavkovich V, Levy D, Factor-Litvak P, Graziano JH, Gamble MV. Associations of Plasma Selenium with Arsenic and Genomic Methylation of Leukocyte DNA in Bangladesh. Environ Health Perspect 2011;119(1):113-8. PMCID: PMC3018489


Project 5: Mobilization of Natural Arsenic in Groundwater

Dhar RK, Y Zheng, CW Saltikov, KA Radloff, B Mailloux, KM Ahmed, A van Geen, Microbes enhance mobility of arsenic in Pleistocene aquifer sand from Bangladesh, Environ Sci Technol, 2011;45(7):2648-54. PMID: 21405115.  dx.doi.org/10.1021/es1022015.

Radloff KA, Y Zheng, HA Michael, M Stute, B Bostick, I Mihajlov, M Bounds, MR Huq, I Choudhury, MW Rahman, P Schlosser, KM Ahmed, A van Geen. Arsenic adsorption protects deep groundwater from widespread contamination in Bangladesh.  Nature Geoscience 2011;4:793-8.


Project 6: Mobilization of anthropogenic arsenic in groundwater

Wovkulich, K. B.J. Mailloux, B.C. Bostick, H. Dong, M.E. Bishop, S.N. Chillrud. Use of microfocused x-ray techniques to investigate mobilization of Arsenic by Oxalic Acid. Geochim. Cosmo. Acta, submitted 2011.

Wovkulich, K., Stute, M., Protus, T. J., Mailloux, B. J. and Chillrud, S. N. (2011), Injection System for Multiwell Injection Using a Single Pump. Ground Water Monitoring & Remediation, 31: 79–85. doi: 10.1111/j.1745-6592.2011.01325.x


Project 7:  Mitigation of Arsenic Mobilization in Groundwater

Aziz, Z, M. Stute, R. Versteeg, P. Schlosser, MR Huq, KM Ahmed, A van Geen, Distribution of As in shallow Bangladesh aquifers of Bangladesh controlled by desorption and flushing: An evaluation at the village-scale using a 3-D groundwater flow model, Water Resources Res, in revision.

Bennear L, A Tarozzi, A Pfaff, HB Soumya, KM Ahmed, A van Geen, Bright lines, risk beliefs, and risk avoidance: Evidence from a randomized intervention in Bangladesh, revision submitted to J Enviro Econom Manage, October 2011.

Chen Y, JH Graziano, F Parvez, M Liu, V Slavkovich, T Kalra, M Argos, T Islam, A Ahmed, M Rakibuz-Zaman, R Hasan, D Levy, A van Geen, and H Ahsan, Arsenic exposure from drinking water and cardiovascular disease mortality: A prospective cohort study in Bangladesh, British Med J 2011;342:d2431.

Dhar, RK, Y Zheng, CW Saltikov, KA Radloff, B Mailloux, KM Ahmed, A van Geen, Microbes enhance mobility of arsenic in Pleistocene aquifer sand from Bangladesh, Environ Science Technol, 2011;45(7):2648-54. dx.doi.org/10.1021/es1022015.

Escamilla, V., B. Wagner, M. Yunus, P.K. Streatfield, A. van Geen, M. Emch, Effect of deep tube well use on childhood diarrhoea in Bangladesh, Bull World Health Organ 2011;89:521-7. PMCID:PMC3127267.

Ferguson AS, AC Layton, BJ Mailloux, PJ Culligan, DE Williams, AE Smartt, J Feighery, L McKay, P Knappett, E Alexandrova, T Arbit, M Emch, V Escamilla, KM Ahmed, MJ Alam, PK Streatfield, M Yunus, A van Geen, Comparison of fecal indicators with pathogenic bacteria and rotavirus in groundwater, submitted to Environ Sci Technol, submitted

Ferguson AS, BJ Mailloux, KM Ahmed, A van Geen, LD McKay, and PJ Culligan, Hand-pumps as reservoirs for microbial contamination of well water, J Water Health 2011;9(4):708-17.

George CM, JH Graziano, Y Zheng, JL Mey, A van Geen,  Evaluation of the effectiveness of building local capacity to conduct arsenic testing services in Bangladesh, Environmental Health, in revision.

George CM, D Levy, T Islam, KM Ahmed, J Moon-Howard, A Tarozzi, X Liu, P Factor-Litvak, A van Geen, JH Graziano, A cluster-based randomized controlled trial promoting community participation in arsenic mitigation efforts in Singair, Bangladesh, submitted.

Khan, K, Factor-Litvak, P, Wasserman, GA, Liu, X, Ahmed, E, Parvez, F, Slavkovich, V, Levy, D, Mey, J, van Geen, A, Graziano, JG:  Manganese exposure from drinking water and children’s classroom behavior in Bangladesh.  Environ Health Perspect 2011;119:1501-6. PMID: 21493178. PMCID: in process.

Khan, K, GA Wasserman, X Liu, E Ahmed, F Parvez, V Slavkovich, D Levy, J Mey, A van Geen, JH Graziano, P Factor-Litvak, Manganese exposure from drinking water and children’s academic achievement, revision submitted to Neurotoxicology, 2011; in press.

Knappett, PSK, V Escamilla, A Layton, LD McKay, M Emch, DE Williams, MR Huq, MJ Alam, L Farhana, BJ Mailloux, A Ferguson, GS Sayler, KM Ahmed, A van Geen. Impact of population and latrines on fecal contamination of ponds in rural Bangladesh. Sci Tot Environ, 2011; 409(17):3174-82. PMCID: PMC3150537.

Knappett PSK, LD McKay, A Layton, DE Williams, MJ Alam, MR Huq, J Mey, JE Feighery, PJ Culligan, BJ Mailloux, J Zhuang, V Escamilla, M Emch, E Perfect, GS Sayler, KM Ahmed, A van Geen, Fecal contamination of shallow groundwater modulated by the geological setting of ponds, Environ Sci Technol, in revision.

Parvez F, GA Wasserman, P Factor-Litvak, X Liu, V Slavkovich, AB Siddique, Rebeka Sultana, Ruksana Sultana, T Islam, D Levy, JL Mey, A van Geen, KM Khan, J Kline, H Ahsan, JH Graziano, Arsenic exposure and motor function among children in Bangladesh, Environ Health Perspect 2011;119:1665-70.

Radloff KA, Y Zheng, HA Michael, M Stute, B Bostick, I Mihajlov, M Bounds, MR Huq, I Choudhury, MW Rahman, P Schlosser, KM Ahmed, A van Geen. Arsenic adsorption protects deep groundwater from widespread contamination in Bangladesh.  Nature Geoscience 2011;4:793-8.

Soumya HB, A Pfaff, L Bennear, A Tarozzi, KM Ahmed, A Schoenfeld, A van Geen, Rising gains over time from the provision of health-risk information: evidence from the groundwater arsenic crisis in Bangladesh, submitted to Bulletin of the World Health Organization, August 2011.

van Geen A, KM Ahmed, Y Akita, MJ Alam, PJ Culligan, J Feighery, A Ferguson, M Emch, V Escamilla, P Knappett, AC Layton, BJ Mailloux, LD McKay, JL Mey, ML Serre, PK Streatfield, J Wu, M Yunus, Fecal contamination of shallow tubewells in Bangladesh inversely related to arsenic, Environ Sci Technol, DOI: 10.1021/es103192b, 2011; in press.  PMCID: PMC3037737

Wasserman, GA, X Liu, F Parvez, P Factor-Litvak, H Ahsan, D Levy, J Kline, A van Geen, J Mey, V Slavkovich, AB Siddique, T Islam, JH Graziano, Arsenic and manganese exposure and children's intellectual function, Neurotoxicology 2011;32:450-7.

Wu, F,  F Jasmine, MG Kibriya, M Liu, O Wojcik, F Parvez, S Roy, R Rahaman, S Segers, V Slavkovich, T Islam, D Levy, A van Geen, J Graziano, H Ahsan, Y Chen, Association between arsenic exposure from drinking water and plasma levels of cardiovascular markers, Amer J Epidemiol, in press, 2011.

Wu J, A van Geen, KM Ahmed,Y Akita, MJ Alam, PJ Culligan, V Escamilla, J Feighery, AS Ferguson, P Knappett, BJ Mailloux, LD McKay, ML Serre, PK Streatfield, M Yunus, M Emch, Increase in diarrheal disease associated with arsenic mitigation in Bangladesh, PLoS ONE, 2011; in press.

Wu, J, M Yunus, PK Streatfield, A van Geen, V Escamilla, Y Akita, M Serre,  M Emch, Impact of tubewell access and depth on childhood diarrhea in Matlab, Bangladesh, 2nd revision submitted to J Environ Health, December 2011.


Core B:  Trace Metals Core Laboratory

Every publication listed for Projects 2, 3 and 4 has relied on the Trace Metal Core.


Core C: Biogeochemistry Core

Aziz, Z, M. Stute, R. Versteeg, P. Schlosser, MR Huq, KM Ahmed, A van Geen, Distribution of As in shallow Bangladesh aquifers of Bangladesh controlled by desorption and flushing: An evaluation at the village-scale using a 3-D groundwater flow model, Water Resources Research, under revision February 2011.

Chen Y, JH Graziano, F Parvez, M Liu, V Slavkovich, T Kalra, M Argos, T Islam, A Ahmed, M Rakibuz-Zaman, R Hasan, D Levy, A van Geen, and H Ahsan, Arsenic exposure from drinking water and cardiovascular disease mortality: A prospective cohort study in Bangladesh, British Med J 342:d2431, 2011.

Dhar, RK, Y Zheng, CW Saltikov, KA Radloff, B Mailloux, KM Ahmed, A van Geen, Microbes enhance mobility of arsenic in Pleistocene aquifer sand from Bangladesh, Environ Science Technol, 2011;45(7):2648-54. dx.doi.org/10.1021/es1022015.

George CM, JH Graziano, Y Zheng, JL Mey, A van Geen,  Evaluation of the effectiveness of building local capacity to conduct arsenic testing services in Bangladesh, Environ Health, in revision.

Khan, K, Factor-Litvak, P, Wasserman, GA, Liu, X, Ahmed, E, Parvez, F, Slavkovich, V, Levy, D, Mey, J, van Geen, A, Graziano, JG:  Manganese exposure from drinking water and children’s classroom behavior in Bangladesh.  Environ Health Perspect 2011;119:1501-6.  PMID:  21493178. PMCID: in process.

Khan, K, Wasserman, G, Liu, X, Ahmed, E, Parvez, F, Slavkovic, V, Levy, D, Mey, J, van Geen, A, Graziano, J, Factor-Litvak, P:  Manganese exposure from drinking water and children’s academic achievement.  Neurotoxicology, in press, 2011.

Knappett PSK, LD McKay, A Layton, DE Williams, MJ Alam, MR Huq, J Mey, JE Feighery, PJ Culligan, BJ Mailloux, J Zhuang, V Escamilla, M Emch, E Perfect, GS Sayler, KM Ahmed, A van Geen, Fecal contamination of shallow groundwater modulated by the geological setting of ponds, Environ Sci Technol, revision requested November 2011.

Parvez, F, Wasserman, GA, Factor-Litvak, P, Liu, X, Ahsan, H, Slavkovich, V, Sultana, Re, Sultana, Ru, Levy, D, Kline, J, Siddique, A, Islam, T, Graziano, JH:  Arsenic exposure and motor function among children in Bangladesh.    Environ Health Perspect, 2011;119(11):1665-70. PMID: 21742576 PMCID: in process.

Radloff KA, Y Zheng, HA Michael, M Stute, B Bostick, I Mihajlov, M Bounds, MR Huq, I Choudhury, MW Rahman, P Schlosser, KM Ahmed, A van Geen. Arsenic adsorption protects deep groundwater from widespread contamination in Bangladesh.  Nature Geoscience 2011;4:793-8.

van Geen A, KM Ahmed, Y Akita, MJ Alam, PJ Culligan, J Feighery, A Ferguson, M Emch, V Escamilla, P Knappett, AC Layton, BJ Mailloux, LD McKay, JL Mey, ML Serre, PK Streatfield, J Wu, M Yunus, Fecal contamination of shallow tubewells in Bangladesh inversely related to arsenic, Environ Sci Technol, DOI: 10.1021/es103192b, 2011; in press.  PMCID: PMC3037737

Wasserman, GA, Liu, X, Parvez, F, Factor-Litvak, P, Ahsan, H, Levy, D, Kline, J, van Geen, A, Mey, J, Slavkovich, V, Siddique, A, Islam, T, Graziano, JH:  Arsenic and manganese exposure and children’s intellectual function.  Neurotoxicology 2011;32:450-7. PMID:  21453714. PMCID: in process.

Wu, F,  F Jasmine, MG Kibriya, M Liu, O Wojcik, F Parvez, S Roy, R Rahaman, S Segers, V Slavkovich, T Islam, D Levy, A van Geen, J Graziano, H Ahsan, Y Chen, Association between arsenic exposure from drinking water and plasma levels of cardiovascular markers, Amer J Epidemiol, in press,  2011.


Core D: Hydrogeology Support Laboratory

All publications listed in Projects 5, 6, 7 and RTC have been supported by the Hydrogeology Core. Of particular relevance are the following:

Aziz, Z. et al. Distribution of As in shallow aquifers of Bangladesh controlled by desorption and flushing: An evaluation at the village-scale using a 3-D groundwater flow model. Water Resources Research, under revision, Nov. 2011.

Radloff KA, Y Zheng, HA Michael, M Stute, B Bostick, I Mihajlov, M Bounds, MR Huq, I Choudhury, MW Rahman, P Schlosser, KM Ahmed, A van Geen. Arsenic adsorption protects deep groundwater from widespread contamination in Bangladesh.  Nature Geoscience 2011;4:793-8.


Research Translation Core: Collaborating with Government & the Public:  Arsenic & Manganese Exposure via Groundwater

Braman S, S Gruber, Hurdles to incorporating conservation into long-term water supply planning: a Rockland County NY case study, published in the AWWA Symposium Showcase Conference Proceedings, 2011,Tuesday 2C-2: 1-15.  Papers selected from the AWWA Water Conservation Symposium, March 2011, Orlando, Fl.

Bostick BC, J Sun, K Wovkulich, M Stute, B Mailloux, SN Chillrud. Evaluation of Potential Strategies for the Effective Remediation of Arsenic- Contaminated Superfund Sites. Presented at the 12th annual Research & Industrial Collaboration Conference (RICC) at Northeastern University on October 13, 2011, Boston, MA (invited).

Chai-Onn T, G Yetman, and M Golden (presenter). 2011. Interactive Mapping Service: Superfund Sites and Vulnerable Populations: Computer Demonstration of Work in Progress. Superfund Research Program Annual Meeting. Lexington, KY, 23 October 2011.

Golden M. 2011. Breakout Session 1: GIS Applications for SRP . Discussion Leader. Superfund Research Program RTC Annual Meeting. Lexington, KY, 26 October 2011.

Wovkulich K, Stute M, Protus TJ, Mailloux BJ and Chillrud SN. (2011), Injection System for Multiwell Injection Using a Single Pump. Ground Water Monitoring & Remediation, 31: 79–85. doi: 10.1111/j.1745-6592.2011.01325.x


2010 Publications

2010 Annual Project and Core Updates (pdf)

Project 1: Genotoxic and Cell Signaling Pathways of Arsenic in Mammalian Cells

Karasic, T., Tom K. Hei, and Vladimir N. Ivanov. 2010. “Disruption of IGF-1R signaling increases TRAIL-induced apoptosis: a new potential therapy for the treatment of melanoma.” Experimental Cell Research,. 316:1994-2007. doi:10.1016/j.yexcr.2010.04.014.


Project 2: A Cohort Study of Health Effects of Arsenic Exposure in Bangladesh

Argos, Maria, T. Kalra, Paul J. Rathouz, Yu Chen, B.L. Pierce, Faruque Parvez, Tariqul Islam, Alaudinn Ahmed, Muhammad Rakibuz-Zaman, R. Hasan, Golam Sarwar, Vesna Slavkovich, Alexander F. Van Geen, Joseph H. Graziano, and Habibul Ahsan. 2010. “Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study”. Lancet. 376:252-258. doi:10.1016/S0140-6736(10)60481-3.

Heck, J., J. Nieves, Yu Chen, Faruque Parvez, Paul W. Brandt-Rauf, Geoffrey R. Howe, and Habibul Ahsan. 2010. “Protein and amino acid intakes in a rural area of Bangladesh.” Food and Nutrition Bulletin. 31:206-213.

Parvez, Faruque, Yu Chen, Paul W. Brandt-Rauf, Vesna Slavkovich, Tariqul Islam, Maria Argos, R. Hassan, M. Yunus, S. Haque, O. Balac, Joseph H. Graziano, and Habibul Ahsan. 2010. “A prospective study of respiratory symptoms associated with chronic arsenic exposure in Bangladesh: findings from the Health Effects of Arsenic Longitudinal Study (HEALS).” Thorax. 65:528-533. doi:10.1136/thx.2009.119347.

Pierce, B.L., T. Kalra, Maria Argos, Faruque Parvez, Yu Chen, Tariqul Islam, Alaudinn Ahmed, R. Hasan, Muhammad Rakibuz-Zaman, Joseph H. Graziano, Paul J. Rathouz, and Habibul Ahsan. 2010. “A prospective study of body mass index and mortality in Bangladesh.” International Journal of Epidemiology. 39:1037-1045.doi:10.1093/ije/dyp364.


Project 5: Mobilization of Natural Arsenic in Groundwater

Garnier, J.M., V. Lenoble, J. Rose, Y. Zheng, M. Hossain, S. Chowdhury, Abir Biswas, Kazi Matin Ahmed, Zhongqi Cheng, and Alexander F. Van Geen. 2010. “Temporal variations in arsenic uptake by rice plants in Bangladesh: The role of iron plaque in paddy fields irrigated with groundwater.” Science of the Total Environment. 408:4185-4193. doi:10.1016/j.scitotenv.2010.05.019.


Project 7: Mitigation of Arsenic Mobilization in Groundwater

Argos, Maria, T. Kalra, Paul J. Rathouz, Yu Chen, B.L. Pierce, Faruque Parvez, Tariqul Islam, Alaudinn Ahmed, Muhammad Rakibuz-Zaman, R. Hasan, Golam Sarwar, Vesna Slavkovich, Alexander F. Van Geen, Joseph H. Graziano, and Habibul Ahsan. 2010. “Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study.” Lancet. 376:252-258. doi:10.1016/S0140-6736(10)60481-3.

Fendorf, S., H. Michael, and Alexander F. Van Geen. 2010. “Spatial and Temporal Variations of Groundwater Arsenic in South and Southeast Asia.” Science. 328:1123-1127. doi:10.1126/science.1172974.

Garnier, J.M., V. Lenoble, J. Rose, Y. Zheng, M. Hossain, S. Chowdhury, Abir Biswas, Kazi Matin Ahmed, Zhongqi Cheng, and Alexander F. Van Geen. 2010. “Temporal variations in arsenic uptake by rice plants in Bangladesh: The role of iron plaque in paddy fields irrigated with groundwater.” Science of the Total Environment. 408:4185-4193. doi:10.1016/j.scitotenv.2010.05.019.


2009 Publications

2009 Annual Project and Core Updates (pdf)

Project 1: Genotoxic and Cell Signaling Pathways of Arsenic in Mammalian Cells

Partridge, MA, Huang, SX, Kibriya, MG, Ahsan, H, Davidson, M and Hei, TK. “Environmental mutagens induced transversions but not translations in regulatory region of mitochondrial DNA.” J. Toxicology & Environmental Health 2009;72:301-4..

Wen, GY, Partridge, MA, Calaf, M, Meador, J, Hu, B, Chau-Echiburu, C, Hong, M, and Hei, TK. “Increased susceptibility of human small airway epithelial cells to apoptosis after long term arsenate treatment.” Sci Total Environ. 2009;407:1174-81.

Ivanov, VN, Zhou, H, Partridge, MA, and Hei, TK. “Inhibition of ATM kinase activity enhanced TRAIL-mediated apoptosis in human melanoma cells.” Cancer Res., 2009;69:3510-9.


Project 2: A Cohort Study of Health Effects of Arsenic Exposure in Bangladesh

Chen Y, Parvez F, Gamble M, Islam T, Ahmed A, Argos M, Graziano JH, Ahsan H. “Arsenic exposure at low-to-moderate levels and skin lesions, arsenic metabolism, neurological functions, and biomarkers for respiratory and cardiovascular diseases: review of recent findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh.” Toxicol Appl Pharmacol 2009;239(2):184-92. PMID: 19371619.

Pierce BL, Kalra T, Argos M, Parvez F, Chen Y, Islam T, Ahmed A, Hasan R, Rakibuz-Zaman M, Graziano J, Rathouz PJ, Ahsan H. “A prospective study of body mass index and mortality in Bangladesh.” Int J Epidemiol (In press), 2009.

Additional submissions
Argos M, Rathouz PJ, Pierce BL, Kalra T, Chen Y, Parvez F, Slavkovich V, Ahsan H. “Dietary B vitamin group intakes and urinary total arsenic concentration in the Health Effects of Arsenic Longitudinal Study (HEALS) cohort, Bangladesh.” Under Review (2009).

Argos M, Kalra T, Rathouz PJ, Chen Y, Pierce B, Islam T, Ahmed A, Hassan R, Parvez F, Graziano J, Ahsan H. “A Prospective Study of Arsenic Exposure from Drinking Water and Incidence of Skin Lesions in Bangladesh.” Under Review (2009).

Kalra T, Argos M, Rathouz PJ, Chen Y, Pierce B, Parvez F, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Graziano J, Ahsan H. “A Prospective Cohort Study of Arsenic Exposure from Drinking Water and All-cause and Chronic Disease Mortality in Bangladesh.” Under Review (2009).


Project 3: Consequences of Arsenic and Manganese Exposure on Childhood Intelligence

There have been no publications from project #3 during the past year, though the PI has been a co-author of 5 other publications derived from projects #2 and #4. This is due to the fact that we have been conducting field work throughout the year. We anticipate, however, that the fruits of that fieldwork, and the ongoing statistical analyses, will very soon yield a series of novel findings and publications concerning the effects of As and Mn exposure in children.

Manuscripts in progress
Wasserman, G, Liu, X, Parvez, F, Siddiqui, S, Factor-Litvak, P, Kline, J, van Geen, A, Slavkovich, V, LoIacono, N, Levy, D, Graziano, JH. “Adverse associations of arsenic and manganese exposure with child intelligence in 7-9 year old children in Bangladesh.” In preparation.

Wasserman, G, Liu, X, Parvez, F, Siddiqui, S, Factor-Litvak, P, Kline, J, van Geen, A, Slavkovich, V, LoIacono, N, Levy, D, Graziano, JH. “Positive associations between blood selenium and motor function in 7-9 year old children in Bangladesh.” In preparation.


Project 4: One-Carbon Metabolism, Oxidative Stress and Arsenic Toxicity in Bangladesh

Hall MN, Liu X, Slavkovich V, Ilievski V, Pilsner JR, Alam S, Factor-Litvak P, Graziano JH, Gamble MV. “Folate, Cobalamin, Cysteine, Homocysteine, and Arsenic Metabolism among Children in Bangladesh.” Environ Health Perspect 2009;117(5):825-31.

Pilsner JR, Liu X, Ahsan H, Ilievski V, Slavkovich V, Levy D, Factor-Litvak P, Graziano JH, Gamble MV. “Folate deficiency, hyperhomocysteinemia, low urinary creatinine and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions.” Environ Health Perspect 2009;117(2):254-60. PMCID:PMC2649228

Chen Y, Parvez F, Gamble M, Islam T, Ahmed A, Argos M, Graziano JH, and Ahsan H. “Arsenic exposure at low-to-moderate levels and skin lesions, arsenic metabolism, neurological functions, and biomarkers for respiratory and cardiovascular diseases: review of recent findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh. Toxicol.” Applied Pharmacol, 2009;239(2):184-92.

Hall MN, Liu X, Slavkovich V, Ilievski V, Mi Z, Alam S, Factor-Litvak P, Ahsan H, Graziano JH, and Gamble MV. “Influence of Cobalamin on Arsenic Metabolism in Bangladesh.”Environ Health Perspect, 2009;117(11):1724-29.

Additional submissions and manuscripts in progress
Pilsner JR, Hall M, Liu X, Ahsan G, Ilievski V, Slavkovich V, Levy D, Factor-Litvak P, Graziano JH and Gamble MV. “The Influence of Selenium Nutritional Status on Blood and Urinary Arsenic Concentrations, Arsenic Methylation, and Genomic Methylation of Leukocyte DNA.” Environ Health Perspect (submitted).

Pilsner JR, Liu X, Hall M, Rahman M, Factor-Litvak P, Graziano JH, and Gamble MV. “Influence of maternal arsenic exposure on genomic DNA methylation in maternal-newborn pairs.” (manuscript in preparation).

Pilsner JR, Liu X, Ahsan H, Ilievski V, Slavkovich V, Levy D, Factor-Litvak P, Graziano JH, Gamble MV. “Influence of folic acid supplementation on DNA methylation in Bangladeshi adults.” (manuscript in preparation).


Project 5: Mobilization of Natural Arsenic in Groundwater

Datta S, Mailloux B, Jung HB, Hoque MA, Stute M, Ahmed KM, and Zheng Y. “Redox trapping of arsenic during groundwater discharge in sediments from the Meghna riverbank in Bangladesh.” Proceedings of the National Academy of Sciences 2009;106(40):16930-5. PMCID: 2761342

Jung HB, Charette MA, and Zheng Y. “Field, Laboratory, and Modeling Study of Reactive Transport of Groundwater Arsenic in a Coastal Aquifer.” Environmental Science & Technology 2009;43(14):5333-8. PMCID: 2761342

Radloff, KA, Zheng, Y, Stute, M, Ahmed, KM, Schlosser, P, and van Geen, A. “Effect of groundwater flow on dissolved As in a Bangladesh aquifer.” Geochimica Et Cosmochimica Acta 2009;73:A1067-A1067.

Stute, M, Horneman, A, and Fried, R. “Environmental tracers in hydrogeology: Principles, applications, and challenges.” Geochimica Et Cosmochimica Acta 2009;73:A1287-A1287.

Yang Q., Jung H. B., Culbertson C. W., Marvinney R. G., Loiselle M. C., Locke D. B., Cheek H., Thibodeau H., and Zheng Y. (2009) “Spatial Pattern of Groundwater Arsenic Occurrence and Association with Bedrock Geology in Greater Augusta, Maine.” Environmental Science & Technology 2009;43(8):2714-9.

Additional submissions
He Y and Zheng Y. (submitted) “Mass Balance Approach for Evaluation of Urinary Excretion of Arsenic Metabolites Before and After Rice Diet.” Science of the Total Environment.

Jung HB and Zheng Y. (submitted-a) “Fate of Arsenic during Groundwater Discharge to Meghna River Part II: Aqueous Geochemistry.” Geochimica Cosmochimica Acta.

Jung HB and Zheng Y. (submitted-b) “Mobility of Arsenic in Sediment from Meghna Riverbank, Bangladesh Evaluated by Sorption and Desorption Experiments.” Env. Sci. Tech.

Jung HB, Zheng Y, Bostick B, Datta S, Rahman MW, Rahman MM, and Ahmed KM. (submitted) “Fate of Arsenic during Groundwater Discharge to Meghna River Part I: Sediment Geochemistry.” Geochimica Cosmochimica Acta.


Project 6: Mobilization of anthropogenic arsenic in groundwater

Submissions
Wovkulich, K., M. Stute, T. Protus, B. Mailloux, S. Chillrud, “Injection System for Multi-Well Injection Using a Single Pump” (submitted to Ground Water, Nov 2009).

Wovkulich, K., Mailloux, B. J., Lacko, A., Keimowitz, A. R., Stute, M., Simpson, H. J., Chillrud, S.N., “Chemical Treatments for Mobilizing Arsenic from Contaminated Aquifer Solids to Accelerate Remediation” (submitted to Applied Geochemistry Dec 2009).

Meetings
Wovkulich, K., M. Stute, T. Protus, B. Mailloux, S. Chillrud, “Design of an Inexpenseive Injection System as an Example of Technology Transfer from Working Directly at a Superfund Site”, Poster at the annual Superfund Research Program Meeting, New York, NY, Nov 2009.

Wovkulich, K., M. Stute, B. Mailloux, A.R. Keimowitz, D. Ntarlagiannis, L. Slater, H.J. Simpson, S. Chillrud, “Laboratory and Field Studies to Accelerate Arsenic Remediation at the Vineland Superfund Site,” Presentation at the annual Superfund Research Program Meeting, New York, NY, Nov 2009.


Project 7: Mitigation of Arsenic Mobilization in Groundwater

Leber, J, MM Rahman, MT, Chowdury, KM Ahmed, B. Mailloux, A. van Geen, “Seasonal variation of E. coli concentrations in the shallow aquifer of two geologically contrasting villages in Bangladesh”, Ground Water, provisionally accepted by the Guest Editor, November 2009.

van Geen, A, JM. Duxbury, Comment on “Growing rice aerobically markedly decreases arsenic accumulation”, Environmental Science and Technology, DOI: 10.1021/es9002982, 2009.

Additional submissions
Aziz, Z, B Bostick, Y Zheng, MR Huq, MM Rahman, KM. Ahmed, and A. van Geen, “Suppression of arsenic release to shallow groundwater of Bangladesh by reduced sulfur”, submitted to PNAS, October 2009.

Fendorf, F, HA. Michael, A van Geen, “Does the distribution of arsenic in groundwater change over time in South and Southeast Asia? Biogeochemical and hydrological factors to consider”, Review commissioned by Science, submitted December 2009.

Garnier, J.-M, F. Travassac, V. Lenoble, J. Rose, Y. Zheng, M. Hossain, S. Chowdhury, A. Biswas, K.M. Ahmed; Z. Cheng, A. van Geen, “Temporal variations in arsenic uptake by rice plants: The role of iron plaque in paddy fields of Bangladesh irrigated with groundwater”, submitted to Science of the Total Environment, October 2009.


Trace Metals Core Laboratory (Core B)

Hall MN, Liu X, Slavkovich V, Ilievski V, Mi Z, Alam S, Factor-Litvak P, Ahsan H, Graziano JH, and Gamble MV. “Influence of Cobalamin on Arsenic Metabolism in Bangladesh”, Environ Health Perspect, 2009;117(11):1724-9.

Every publication listed for Projects 2, 3 and 4 has relied on the Trace Metal Core.


Biogeochemistry Core (Core C)

Mailloux, B. J., Alexandrova, E., Keimowitz, A., Wovkulich, K., Freyer, G., Herron, M. M., Stolz, J. F., Kenna, T., Pichler, T., P. Knappett, 2007. “Microbial mineral weathering for nutrient acquisition releases arsenic.” Appl. Environ. Microbiol., published 2009.

Additional submissions
Aziz, Z., B. Bostick, Y. Zheng, M.R Huq, M.M. Rahman, K.M. Ahmed, and A. van Geen, “Suppression of arsenic release to shallow groundwater of Bangladesh by reduced sulfur”, submitted to PNAS, November 2009.


Hydrogeology Core (Core D)

All publications listed in Projects 5, 6, 7 and RTC have been supported by the Hydrogeology Core. Of particular relevance are the following:

Datta, S, Mailloux, B, Jung, HB, Hoque, MA, Stute, M, Ahmed, KM, and Zheng, Y. “Redox trapping of arsenic during groundwater discharge in sediments from the Meghna riverbank in Bangladesh.” Proc Natl Acad Sci USA 2009;106:16930-5. PMCID: 2761342.

Friedrich, R, Schlosser, P, Turrin, B, Newton, R, Stute, M, and Plummer, LN. “The Lamont-Doherty Tritium/He-3 Dataset for Age Dating of Groundwater.” Geochim Cosmochim Acta 2009;73:A397-A397.

Loose, B, Stute, M, Alexander, P, and Smethie, WM. (2009). “Design and deployment of a portable membrane equilibrator for sampling aqueous dissolved gases.” Water Res Research 2009;45. W00D34, doi:10.1029/2008WR006969.

Stute, M., Horneman, A., and Fried, R. (2009). “Environmental tracers in hydrogeology: Principles, applications, and challenges.” Geochim Cosmochim Acta 2009;73, A1287-A1287.

Additional submissions
Wovkulich, K., M. Stute, T. Protus, B. Mailloux, S. Chillrud, “Injection System for Multi-Well Injection Using a Single Pump”, submitted to Ground Water, Nov 2009.

Wovkulich, K., M. Stute, T. Protus, B. Mailloux, S. Chillrud, “Injection System for Multi-Well Injection Using a Single Pump”, Provisional Patent Application filed Nov. 2009.


Research Translation Core: Collaborating with Government & the Public: As & Mn Exposure via Groundwater

Balletta, M. 2009. “Arsenic in Iron Floc and Groundwater Downgradient of Unlined Landiflls in Southeastern New York State.” Undergraduate Dissertation, Second University of Naples, Naples, Italy, 182 pp.

Yang, Q, HB Jung, CW Culbertson, RG Marvinney, MC Loiselle, DB Locke, H Cheek, H Thibodeau, Y Zheng. “Spatial Pattern of Groundwater Arsenic Occurrence and Association with Bedrock Geology in Greater Augusta, Maine.” Environ. Sci. Technol., 2009;43(8):2714-9 DOI: 10.1021/es803141m.

Meetings
Golden, M, S Chillrud and T Chai-Onn. “SRP Research Translation: Past, Present, and Future” Poster exhibited at the SRP Annual Meeting in NYC on November 3-4, 2009.

Golden, M. “Research Translation Cores: Promoting and Improving the Use of SRP Science to Enhance Public Health.” Presentation at the SRP Annual Meeting in NYC on November 4, 2009.


2008 Publications

2008 Annual Project and Core Updates (pdf)

Project 1: Genotoxic and Cell Signaling Pathways of Arsenic in Mammalian Cells

Ivanov, V., Partridge, M.A., Johnson, J.E., Huang, S.X.L., Zhou, H., and Hei, T.K., “Resveratrol sensitizes human melanomas to TRAIL through modulation of anti-apoptotic gene expression in conditions of partial suppression of mitochondrial function.” Exp. Cell Research 314: 1163-1176, 2008.

Wen, G.Y., Calaf, G.M., Partridge, M.A., Chau-Echiburu, C., Zhao, Y., Huang., S.X.L., Chai, Y.L., Li, B.Y., Hu, B. and Hei, T.K., “Neoplastic transformation of human small airway epithelial cells induced by arsenic.” Mol. Medicine 14: 2-10, 2008.

Wen, G.Y., Partridge, M.A., Calaf, M., Meador, J., Hu, B., Chau-Echiburu, C., Hong, M., and Hei, T.K., “Increased susceptibility of human small airway epithelial cells to apoptosis after long term arsenate treatment.” Sc. Total Environment: 2008 Oct 30. [Epub ahead of print]

Partridge, M.A., Huang, S. X.L., Kibriya, M.G., Ahsan, H., Davidson, M.and Hei, T.K., “Environmental mutagens induced transversions but not translations in regulatory region of mitochondrial DNA.” J. Toxicology & Environmental Health (In press, 2008).

Project 2: A Cohort Study of Health Effects of Arsenic Exposure in Bangladesh

Chen, Y., R. M. Santella, et al. (2007). “Association between arsenic exposure from drinking water and plasma levels of soluble cell adhesion molecules.” Environ Health Perspect 115(10): 1415-20.

Heck, J. E., Y. Chen, et al. (2008). “Arsenic exposure and anemia in Bangladesh: a population-based study.” J Occup Environ Med 50(1): 80-7.

Parvez F, Chen Y, Brandt-Rauf PW, et al. “Nonmalignant respiratory effects of chronic arsenic exposure from drinking water among never-smokers in Bangladesh.” Environ Health Perspect. Feb 2008;116(2):190-195.

Zablotska, L. B., Y. Chen, et al. (2008). “Protective effects of B vitamins and antioxidants on the risk of arsenic-related skin lesions in Bangladesh.” Environ Health Perspect 116(8): 1056-62.

Additional submissions
Kalra, T.K. Ahsan, H. (Submitted 2008) “Arsenic Exposure from Drinking Water and All-Cause and Chronic Disease Mortality in Bangladesh” JAMA

Project 3: Consequences of Arsenic and Manganese Exposure on Childhood Intelligence

There have been no publications from project #3 during the past year, though the PI has been a co-author of 6 other publications derived from projects #2 and #4. This is due to the fact that we have been conducting field work throughout the year. We anticipate, however, that the fruits of that fieldwork, and the ongoing statistical analyses, will very soon yield a series of novel findings and publications concerning the effects of As and Mn exposure in children.

Project 4: One-Carbon Metabolism, Oxidative Stress and Arsenic Toxicity in Bangladesh

Gamble MV, Liu X, Ahsan H et al. “Folate, homocysteine and arsenic metabolism in Bangladesh.” Environ Health Perspect 2005;113:1683-8.

Gamble MV, Liu X, Ahsan H et al. “Folate and Arsenic Metabolism: A double-blind placebo controlled folic acid supplementation trial in Bangladesh.” Am J Clin Nutr 2006;84:1093-101.

Gamble MV, Liu X, Slavkovich V et al. “Folic Acid Supplementation Lowers Blood Arsenic.” Am J Clin Nutr 2007;86:1202-9.

Pilsner JR, Liu X, Ahsan H et al. “Folate deficiency, hyperhomocysteinemia, low urinary creatinine and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions.” Environ Health Perspect 2008;(in press).

Additional submissions and manuscripts in preparation
Chen Y, Parvez F, Gamble M, Islam T, Graziano JH, and Ahsan H. “Health Effects of Arsenic Exposure from Drinking Water in Bangladesh: Key Findings from the Health Effects of Arsenic Longitudinal Study (HEALS)” (in review, Toxicology and Applied Pharmacology).

Hall MN, Liu X, Slavkovich V, Ilievski V, Alam S, Factor-Litvak P, Graziano JH, and Gamble MV. “Influence of Cobalamin on Arsenic Metabolism” (manuscript in preparation).

Pilsner JR, Liu X, Hall M, Rahman M, Factor-Litvak P, Graziano JH, and Gamble MV. “Influence of maternal arsenic exposure on genomic DNA methylation in maternal-newborn pairs” (manuscript in preparation).

Pilsner JR, Liu X, Ahsan H, Ilievski V, Slavkovich V, Levy D, Factor-Litvak P, Graziano JH, Gamble MV. “Influence of folic acid supplementation on DNA methylation in Bangladeshi adults” (manuscript in preparation).

Project 5: Mobilization of Natural Arsenic in Groundwater

Aziz Z, van Geen A, Stute M, Versteeg R, Horneman A, Zheng Y, Goodbred S, Steckler M, Weinman B, Gavrieli I, Hoque MA, Shamsudduha M, Ahmed KM. (2008) “Impact of local recharge on arsenic concentrations in shallow aquifers inferred from the electro-magnetic conductivity of soils in Araihazar, Bangladesh.” Water Resources Res 44(7).

Dhar RK, Zheng Y, Stute M, van Geen A, Cheng Z, Shanewaz M, Shamsudduha M, Hoque MA, Rahman MW, Ahmed KM. (2008) “Temporal variability of groundwater chemistry in shallow and deep aquifers of Araihazar, Bangladesh.” J Contaminant Hydrology 99(1-4), 97-111.

Horneman A, Stute M, Schlosser P, Smethie W, Santella N, Ho DT, Mailloux B, Gorman E, Zheng Y, van Geen A. (2008) “Degradation rates of CFC-11, CFC-12 and CFC-113 in anoxic shallow aquifers of Araihazar, Bangladesh.” J Contaminant Hydrology 97(1-2), 27-41.

Radloff KA, Manning AR, Mailloux B, Zheng Y, Moshiur Rahman M, Rezaul Huq M, Ahmed KM, and Geen Av. (2008) “Considerations for conducting incubations to study the mechanisms of As release in reducing groundwater aquifers.” Applied Geochemistry 23(11), 3224.

van Geen A., Radloff K., Aziz Z., Cheng Z., Huq M. R., Ahmed K. M., Weinman B., Goodbred S., Jung H. B., Zheng Y., Berg M., Trang P. T. K., Charlet L., Metral J., Tisserand D., Guillot S., Chakraborty S., Gajurel A. P., and Upreti B. N. (2008a) “Comparison of arsenic concentrations in simultaneously-collected groundwater and aquifer particles from Bangladesh, India, Vietnam, and Nepal.” Applied Geochemistry 23(11), 3244.

van Geen A., Zheng Y., Goodbred S., Horneman A., Aziz Z., Cheng Z., Stute M., Mailloux B., Weinman B., Hoque M. A., Seddique A. A., Hossain M. S., Chowdhury S. H., and Ahmed K. M. (2008b) “Flushing history as a hydrogeological control on the regional distribution of arsenic in shallow groundwater of the Bengal Basin.” Environmental Science & Technology 42(7), 2283-2288.

Weinman B., Goodbred S. L., Zheng Y., Aziz Z., Steckler M., van Geen A., Singhvi A. K., and Nagar Y. C. (2008) “Contributions of floodplain stratigraphy and evolution to the spatial patterns of groundwater arsenic in Araihazar, Bangladesh.” Geological Society of America Bulletin 120(11-12), 1567-1580.

Additional submissions
He Y. and Zheng Y. (2008) “Comparison of the Urinary Excretion of Arsenic Metabolites Before and After Rice Diet.” Toxicol. Appl. Pharmacol.submitted.

Jung HB, Charette MA, Zheng Y. (2008) “A field, laboratory and modeling study of reactive transport of groundwater arsenic in a coastal aquifer.” Env. Sci. Tech. submitted.

Loose B, Stute M, Alexander P, Smethie WM. (2008) “Design and deployment of a portable membrane equilibrator for sampling aqueous dissolved gases.” Water Res. Res., submitted.

Yang Q., Jung H. B., Culbertson C. W., Marvinney R. G., Loiselle M. C., Locke D. B., Cheek H., Thibodeau H., and Zheng Y. (2008) “Spatial Pattern of Groundwater Arsenic Occurrence and Association with Bedrock Geology in Greater Augusta, Maine, USA.” Env. Sci. Tech. submitted.

Project 6: Mobilization of anthropogenic arsenic in groundwater

Abstracts and meetings
Keimowitz, A. R., S. N. Chillrud, J. N. Ross, B. J. Mailloux, M. Stute, and R. Waldholz. 2008. “Arsenic Cycling in Union Lake, NJ.” Geological Society of America Abstracts with Programs, Vol. 40, No. 6, p. 459.

Keimowitz, A. R., B. J. Mailloux, S. N. Chillrud, J. M. Ross, K. Wovkulich, P. McNamara, E. Alexandrova, and L. Thompson. 2008. “Arsenic Movement From Sediment to Water: Microbes and Mobilization in a Contaminated Lake.” Eos Trans. AGU, 89:Fall Meet. Suppl., Abstract H41E-0916.

Wagner, P. J., B. J. Mailloux, R. Foster, J. F. Stolz, M. Scholz, K. Wovkulich, A. R. Keimowitz, B. Lanoil, A. Van Geen, and G. Freyer. 2008. “Worldwide Diversity and Occurrence of Arsenite Transporter acr3(2) Suggests An Important and Overlooked Pathway.” Geological Society of America Abstracts with Programs, Vol. 40, No. 6, p. 523.

Wovkulich, K., M. Stute, H.J. Simpson, B. Mailloux, A. Lacko, A.R. Keimowitz, Z. Cheng, S. Chillrud, “Increasing Arsenic Mobilization from Contaminated Sediments to Improve Remediation Efficiency, Poster at the 2nd International Congress on Arsenic, Valencia, Spain, May 2008.

Wovkulich, K., M. Stute, B. Mailloux, H.J. Simspon, A.R. Keimowitz, A. Powell, S.N. Chillrud, “Accelerating Pump-and-Treat Remediation of Arsenic: Preparations for In Situ Arsenic Mobilization”, Poster at the annual Superfund Basic Research Program Meeting, Pacific Grove, CA, Dec 2008.

Wovkulich K., B. Mailloux, M. Stute, H.J. Simpson, A.R. Keimowitz, A. Powell, A. Lacko, S.N. Chillrud, “Arsenic Remediation Enhancement through Chemical Additions to Pump-and Treat Operations”, Oral presentation at the fall annual American Geophysical Union Meeting, San Francisco, CA, Dec 2008.

Project 7: Mitigation of Arsenic Mobilization in Groundwater

Auffan, M., J. Rose, O. Proux, D. Borschneck, A. Masion, P. Chaurand, J.L. Hazemann, C. Chaneac, J.P. Jolivet, M. Wiesner, A. van Geen, J.Y. Bottero (2008) “Enhanced adsorption of arsenic onto maghemites nanoparticles: As(III) as a probe of the surface structure and heterogeneity.” Langmuir 24, 3215-3222.

Aziz Z., van Geen A., Stute M., Versteeg R., Horneman A., Zheng Y., Goodbred S., Steckler M., Weinman B., Gavrieli I., Hoque M. A., Shamsudduha M., and Ahmed K. M. (2008) “Impact of local recharge on arsenic concentrations in shallow aquifers inferred from the electromagnetic conductivity of soils in Araihazar, Bangladesh.” Water Resources Research 44(7).

Dhar R. K., Zheng Y., Stute M., van Geen A., Cheng Z., Shanewaz M., Shamsudduha M., Hoque M. A., Rahman M. W., and Ahmed K. M. (2008) “Temporal variability of groundwater chemistry in shallow and deep aquifers of Araihazar, Bangladesh.” Journal Of Contaminant Hydrology 99(1-4), 97-111.

Horneman A., Stute M., Schlosser P., Smethie W., Santella N., Ho D. T., Mailloux B., Gorman E., Zheng Y., and van Geen A. (2008) “Degradation rates of CFC-11, CFC-12 and CFC-113 in anoxic shallow aquifers of Araihazar, Bangladesh.” Journal Of Contaminant Hydrology 97(1-2), 27-41.

Métral, J., L. Charlet, S. Bureau, S. B. Mallik, S. Chakraborty, K.M. Ahmed, M.W. Rahman, Z. Cheng, and A.van Geen (2008). “Comparison of dissolved and particulate arsenic distributions in shallow aquifers of Chakdaha, India, and Araihazar, Bangladesh,” Geochemical Transactions 9:1 doi:10.1186/1467-4866-9-1.

Radloff K. A., Manning A. R., Mailloux B., Zheng Y., Moshiur Rahman M., Rezaul Huq M., Ahmed K. M., and Geen A. v. (2008) “Considerations for conducting incubations to study the mechanisms of As release in reducing groundwater aquifers.” Applied Geochemistry 23(11), 3224.

van Geen A., Zheng Y., Goodbred S., Horneman A., Aziz Z., Cheng Z., Stute M., Mailloux B., Weinman B., Hoque M. A., Seddique A. A., Hossain M. S., Chowdhury S. H., and Ahmed K. M. (2008a) “Flushing history as a hydrogeological control on the regional distribution of arsenic in shallow groundwater of the Bengal Basin.” Environmental Science & Technology 42(7), 2283-2288.

van Geen A., Radloff K., Aziz Z., Cheng Z., Huq M. R., Ahmed K. M., Weinman B., Goodbred S., Jung H. B., Zheng Y., Berg M., Trang P. T. K., Charlet L., Metral J., Tisserand D., Guillot S., Chakraborty S., Gajurel A. P., and Upreti B. N. (2008b) “Comparison of arsenic concentrations in simultaneously-collected groundwater and aquifer particles from Bangladesh, India, Vietnam, and Nepal.” Applied Geochemistry 23(11), 3244.

Weinman B., Goodbred S. L., Zheng Y., Aziz Z., Steckler M., van Geen A., Singhvi A. K., and Nagar Y. C. (2008) “Contributions of floodplain stratigraphy and evolution to the spatial patterns of groundwater arsenic in Araihazar, Bangladesh.” Geological Society of America Bulletin 120(11-12), 1567-1580.

Additional submissions
Aziz, Z., B. Bostick, Y. Zheng, M.R Huq, M.M. Rahman, K.M. Ahmed, and A. van Geen, “Suppression of arsenic release to shallow groundwater of Bangladesh by reduced sulfur”, submitted to Nature, December 2008.

Garnier, J.-M., F. Travassac, V. Lenoble, J. Rose, Y. Zheng, M. Hossain, S. Chowdhury, A. Biswas, K.M. Ahmed; Z. Cheng, A. van Geen, “Temporal variations in arsenic uptake by rice plants: The role of iron plaque in paddy fields of Bangladesh irrigated with groundwater”, submitted to New Phytologist, December 2008.

Leber, J., M.M. Rahman, M.T. Chowdury, K.M. Ahmed, B. Mailloux, A. van Geen, “Seasonal variation of E. coli concentrations in the shallow aquifer of two geologically contrasting villages in Bangladesh”, submitted to Ground Water, September 2008

Trace Metals Core Laboratory (Core B)

Virtually every publication listed for Projects 2, 3 and 4 has relied on the Trace Metal Core.

Biogeochemistry Core (Core C)

Submissions involving collaborators supported by Core C
Aziz, Z., B. Bostick, Y. Zheng, M.R Huq, M.M. Rahman, K.M. Ahmed, and A. van Geen, “Suppression of arsenic release to shallow groundwater of Bangladesh by reduced sulfur”, submitted to Nature, December 2008.

Mailloux, B. J., Alexandrova, E., Keimowitz, A., Wovkulich, K., Freyer, G., Herron, M. M., Stolz, J. F., Kenna, T., Pichler, T., P. Knappett, 2007. “Microbial mineral weathering for nutrient acquisition releases arsenic.” Resubmitted to Appl. Environ. Microbiol., October 2008.

Hydrogeology Support Laboratory (Core D)

All publications listed in Projects 5, 6, and 7 have been supported by the Hydrogeology Core.

Research Translation Core: Collaborating with Government & the Public: As & Mn Exposure via Groundwater

Abstracts and meetings
Balletta, M. S. Chillrud, A. Keimowitz, K. Wovkulich, H.J.. Simpson, J. Ross, M. Stute, R. Hon, B. Brandon, S. Parisio and J. Giordano. 2008. “Developing Triage Assessment Tools for Old Landfills and Arsenic.” 2008 Joint Meeting , The Geological Society of America. 5-9 October. Houston, Tx. Geological Society of America Abstracts with Programs, Vol. 40, No. 6, p. 355).

Chillrud, S., A. Keimowitz, M Balleto, K. Wovkulich, H.J. Simpson, J. Ross, M. Stute, R. Hon, B. Brandon, and S. Parisio. “Developing triage assessment tools for old landfills and arsenic.” Presented at the 2nd International Congress on Arsenic. Valencia, Spain, 2008.


2007 Publications

2007 Annual Project and Core Updates (pdf)

Project 1: Genotoxic and Cell Signaling Pathways of Arsenic in Mammalian cells

Partridge, M., Huang, S., Rosa, E., Davidson, M. and Hei, T.K., “Arsenic Induced Mitochondrial DNA Damage and Altered Mitochondrial Oxidative Function: Implications for Genotoxic Mechanisms in Mammalian Cells.” Cancer Research 67: 5239-5247, 2007.

Partridge, M.A., Davidson, M.M., and Hei, T.K., “The complete nucleotide sequence of Chinese hamster mitochondrial DNA.” DNA Sequence 18: 341-346. 2007.

Vladimir, I., Zhou, H., and Hei, T.K., “Gamma-irradiation or alpha-particle exposure sensitize human melanoma cells to TRAIL-mediated apoptosis through upregulation of TRAIL-R2/DR5 expression and translocation to the cell surface.” Cancer Research 67: 5397-5407, 2007.

Xu, A., Huang, S., Lien, Y., Yu., D., and Hei, T.K., “Genotoxic Mechanisms of Asbestos Fibers: Role of Extranuclear Targets.” Chem. Res. Toxicology 20: 724-733, 2007.

In Press
Ivanov, V., Partridge, M.A., Johnson, J.E., Huang, S.X.L., Zhou, H., and Hei, T.K., (In press). “Resveratrol sensitizes human melanomas to TRAIL through modulation of anti-apoptotic gene expression in conditions of partial suppression of mitochondrial function.” Exp. Cell Research(2007).

Wen, G.Y., Calaf, G.M., Partridge, M.A., Chau-Echiburu, C., Zhao, Y., Huang., S.X.L., Chai, Y.L., Li, B.Y., Hu, B. and Hei, T.K., (In press). “Neoplastic transformation of human small airway epithelial cells induced by arsenic.” Mol. Medicine (2007).


Project 2: A Cohort Study of Health Effects of Arsenic Exposure in Bangladesh

Ahsan H, Chen Y, Kibriya MG, Slavkovich V, Parvez F, Jasmine F, et al. “Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh.” Cancer Epidemiol Biomarkers Prev 2007;16(6):1270-8.

Argos M, Parvez F, Chen Y, Hussain AZ, Momotaj H, Howe GR, et al. “Socioeconomic status and risk for arsenic-related skin lesions in Bangladesh.” Am J Public Health 2007;97(5):825-31.

Chen Y, Factor-Litvak P, Howe GR, Graziano JH, Brandt-Rauf P, Parvez F, et al. “Arsenic exposure from drinking water, dietary intakes of B vitamins and folate, and risk of high blood pressure in Bangladesh: a population-based, cross-sectional study.” Am J Epidemiol 2007;165(5):541-52.

Chen Y, Hall M, Graziano JH, Slavkovich V, van Geen A, Parvez F, et al. “A prospective study of blood selenium levels and the risk of arsenic-related premalignant skin lesions.” Cancer Epidemiol Biomarkers Prev 2007;16(2):207-13.

Chen Y, Santella RM, Kibriya MG, Wang Q, Kappil M, Verret WJ, et al. “Association between arsenic exposure from drinking water and plasma levels of soluble cell adhesion molecules.” Environ Health Perspect 2007;115(10):1415-20.

Chen Y, van Geen A, Graziano JH, Pfaff A, Madajewicz M, Parvez F, et al. “Reduction in urinary arsenic levels in response to arsenic mitigation efforts in Araihazar, Bangladesh.” Environ Health Perspect 2007;115(6):917-23.

Hafeman D, Factor-Litvak P, Cheng Z, van Geen A, Ahsan H. “Association between manganese exposure through drinking water and infant mortality in Bangladesh.” Environ Health Perspect 2007;115(7):1107-12.

Heck JE, Gamble MV, Chen Y, Graziano JH, Slavkovich V, Parvez F, et al. “Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh.” Am J Clin Nutr 2007;85(5):1367-74.

Kibriya MG, Jasmine F, Argos M, Verret WJ, Rakibuz-Zaman M, Ahmed A, et al. “Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions.” Toxicol Lett 2007;169(2):162-76.

Li Y, Chen Y, Slavkovic V, Ahsan H, Parvez F, Graziano JH, et al. “Serum levels of the extracellular domain of the epidermal growth factor receptor in individuals exposed to arsenic in drinking water in Bangladesh.” Biomarkers 2007;12(3):256-65.

Pilsner JR, Liu X, Ahsan H, Ilievski V, Slavkovich V, Levy D, Factor-Litvak P, Graziano JH. Gamble MV. “Genomic methylation of peripheral blood leukocyte DNA: influences of arsenic and folate in Bangladeshi adults.” Am J Clin Nutr 2007 Oct;86(4):1179-86.

In Press:
Heck J, Graziano JH, et al. (In press). “Factors Associated with Anemia in an Arsenic-Exposed Population in Bangladesh.” J Occup Env Med.

Mahata J, Argos M, et al. (In press). “Effect of Selenium and Vitamin E Supplementation on Plasma Protein Carbonyl Levels in Patients with Arsenic Related Skin Lesions.” Nutrition and Cancer.

Parvez F, Brnadt-Rauf PW, et al. (In press). “Non-malignant Respiratory Effects of Chronic Arsenic Exposure from Dinking Water in Bangladesh: A Molecular Epidemiological Study.” Environ Health Perspect.


Project 3: Consequences of Arsenic and Manganese Exposure on Childhood Intelligence

Hall M, Gamble M, Slavkovich V, Liu X, Levy D, Cheng Z, van Geen A, Yunus M, Rahman M, Pilsner JR, Graziano J. “Determinants of arsenic metabolism: blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal-newborn pairs.” Environ Health Perspec 2007;115(10):1503-9.

Wasserman, G, Liu, X, Parvez, F, Ahsan, H, Factor-Litvak, P, Kline, J, van Geen, A, Slavkovich, V, LoIacono, N, Levy, D, Cheng, Z, Graziano, JH: “Water arsenic exposure and intellectual function in six year-old children in Araihazar, Bangladesh.” Environ Health Perspect 115(2) 285-289, February 2007.


Project 4: One-carbon Metabolism, Oxidative Stress and Arsenic Toxicity in Bangladesh

Gamble MV, Liu X, Slavkovich V et al. “Folic Acid Supplementation Lowers Blood Arsenic.” Am J Clin Nutr 2007;86:1202-9.


Project 5: Mobilization of Natural Arsenic in Groundwater (formerly Arsenic mobilization in Bangladesh Groundwater)

He, Y., Zheng, Y., Locke, D.C. “Cathodic stripping voltammetric analysis of arsenic species in environmental water samples.” Microchemical Journal 2007; 85, 265.

Stute, M., Zheng, Y., Schlosser, P., Horneman, A., Dhar, R.K., Datta, S., Hoque, M.A., Seddique, A.A., Shamsudduha, M., Ahmed, K.M., van Geen, A. “Hydrological Control of Arsenic Concentrations in Bangladesh aquifers.” Water Resources Research 2007; 43, doi:10.1029/2005WR004499.

Weinman, B., Goodbred, S.L., Zheng, Y., Aziz, Z., Singhvi, A.K., Nagar, Y.C., Steckler, M., van Geen, A. “Contributions of floodplain stratigraphy and evolution to the spatial patterns of groundwater arsenic in Araihazar, Bangladesh.” GSA Bulletin 2007(accepted).

Yu, G.Q., Sun, D.J., Zheng, Y. “Health effects of exposure to natural arsenic in groundwater and coal in China: An overview of occurrence.” Environ Health Perspect 2007;115, 636-642.

Zheng Y. (2007) “The heterogeneity of arsenic in the crust: A linkage to occurrence in Groundwater.” Quaternary Sciences (Chinese)27(1).

In Press or Revision:
Aziz, Z., van Geen, A., Versteeg, R., Horneman, A., Y. Zheng, Goodbred, S., Steckler, M., Stute, M., Weinman, B., Gavrieli, I., Hoque, M.A., Shamsudduha, M., Ahmed, K.M. “Impact of local recharge on arsenic concentrations in shallow aquifers inferred from the electromagnetic conductivity of soils in Araihazar.” Water Resources Research2007 (in revision).

Datta, S., Mailloux, B., Hoque, M.A., Jung, H.-B., Stute, M., Ahmed, K.M., Zheng, Y. “Enrichment of Arsenic in Sediments from the Meghna River Bank in Bangladesh: Implication for Recycling of Arsenic.” Proc Natl Acad Sci U S A 2007 (provisionally accepted).

Horneman, A., Stute, M., Schlosser, P., Smethie Jr, W., Santella, N., Ho, D.T., Mailloux, B., Gorman, E., Zheng, Y., van Geen, A. “Degradation rates of CFC-11, CFC-12 and CFC-113 in anoxic shallow aquifers of Araihazar, Bangladesh.” Journal of Contaminant Hydrology 2007 (in press).


Project 6: Mobilization of Anthropogenic Arsenic in Groundwater

Keimowitz, A.R., B. J. Mailloux, P. Cole, M. Stute, H. J. Simpson, S.N. Chillrud. “Laboratory investigations of sulfate reduction as a groundwater arsenic remediation strategy.” Environ. Sci. Tech 2007, 41, 6718-6724.


Project 7: Mitigation of Arsenic Mobilization in Groundwater

Chen, Y., P. Factor-Litvak, G.R. Howe, J.H. Graziano, P. Brandt-Rauf, F. Parvez, A. van Geen, and H. Ahsan, “Arsenic exposure from drinking water, dietary intakes of B vitamins and folate, and risk of high blood pressure in Bangladesh: A population-based, cross-sectional study.”American Journal of Epidemiology 165, 541-552, 2007.

Chen Y, Hall M, Graziano JH, Slavkovich V, van Geen A, Parvez F, Ahsan H. “A prospective study of blood selenium levels and the risk of arsenic-related premalignant skin lesions.” Cancer Epidemiol Biomarkers Prev 16:207-13, 2007.

Chen, Y., A. van Geen , J. Graziano , A. Pfaff, M. Madajewicz, F. Parvez , I. Hussain, Z. Cheng, V. Slavkovich, T. Islam, and H. Ahsan, “Reduction in urinary arsenic levels in response to arsenic mitigation in Araihazar, Bangladesh.” Environ Health Perspect 115, 917-923, 2007.

Cheng, Z., B.M. Buckley, B. Katz, W. Wright, R. Bailey, K.T. Smith, A. van Geen, “Arsenic in tree rings at a highly contaminated site.” Science of the Total Environment 376, 324-334, 2007.

Madajewicz, M., A. Pfaff, A. van Geen, J. Graziano, I. Hussein, H. Momotaj, R. Sylvi, and H. Ahsan, “Can information alone both improve awareness and change behavior? Response to arsenic contamination of groundwater in Bangladesh.” Journal of Development Economics 84, 731-754, 2007.

Opar, A., A. Pfaff, A. A. Seddique, K. M. Ahmed, J. H. Graziano, and A. van Geen, “Responses of 6500 households to arsenic mitigation in Araihazar, Bangladesh.” Health & Place 13, 164-172, 2007.

Radloff, K.A., Z. Cheng, M.W. Rahman, K.M. Ahmed, B.J. Mailloux, A.R. Juhl, P. Schlosser, and A. van Geen. “Mobilization of arsenic during one-year incubations of grey aquifer sands from Araihazar, Bangladesh.” Environ. Sci. Tech 41, 3639-3645, 2007.

Stute, M., Y. Zheng, P. Schlosser, A. Horneman, R.K. Dhar, M. A. Hoque, A. A. Seddique, M. Shamsudduha, K. M. Ahmed, and A. van Geen, “Hydrological control of As concentrations in Bangladesh groundwater.” Water Resources Research, 43, W09417, doi:10.1029/2005WR004499, 2007

Wasserman,G.A., Liu, X., Parvez, F., Ahsan, H., Factor-Litvak, P., Kline, J., van Geen, A., Slavkovich, V., LoIacono, N.J., Levy, D., Cheng Z., Graziano, J.H., “Water arsenic exposure and intellectual function in 6-year-old children in Araihazar, Bangladesh.” Environ Health Perspect 115, 285-289, 2007.

van Geen, A., Z. Cheng, Q. Jia, A. A. Seddique, M. W. Rahman, M. M. Rahman, and K. M. Ahmed, “Monitoring 51 deep community wells in Araihazar, Bangladesh, for up to 5 years: Implications for arsenic mitigation.” Journal of Environmental Science and Health 42, 1729-1740, 2007.

In Press:
Auffan, M., J. Rose, O. Proux, D. Borschneck, A. Masion, P. Chaurand, J.L. Hazemann, C. Chaneac, J.P. Jolivet, M. Wiesner, A. van Geen, J.Y. Bottero, “Enhanced adsorption of arsenic onto maghemites nanoparticles: As(III) as a probe of the surface structure and heterogeneity.” Langmuir, in press December 2007.

Hafeman, D., P. Factor-Litvak, Z. Cheng, A. van Geen, H. Ahsan, “Association between manganese exposure through drinking water and infant mortality in Bangladesh.” Environ Health Perspect in press March 2007.

Horneman, A., M. Stute, P. Schlosser, W. Smethie Jr, N. Santella, B. Mailloux, E. Gorman, Y. Zheng, and A. van Geen, “Degradation of CFC-11, CFC-12 and CFC-113 in anoxic shallow aquifers of Araihazar, Bangladesh”, submitted to Journal of Contaminant Hydrology, in press November 2007.

Métral, J., L. Charlet, S. Bureau, S. B. Mallik, S. Chakraborty, K.M. Ahmed, M.W. Rahman, Z. Cheng, and A.van Geen, “Comparison of dissolved and particulate arsenic distributions in shallow aquifers of Chakdaha, India, and Araihazar, Bangladesh.” Geochemical Transactions, in press November 2007.

Weinman, B, SL Goodbred Jr., Y. Zheng, Z. Aziz, AK Singhvi, YC Nagar, M. Steckler, A. van Geen, “Contributions of floodplain stratigraphy and evolution to the spatial patterns of groundwater arsenic in Araihazar, Bangladesh.” Geological Society of America Bulletin, in press October 2007.


Research Translation Core: Collaborating with Government & the Public: As & Mn Exposure via Groundwater

Keimowitz, A.R., B. J. Mailloux, P. Cole, M. Stute, H.J. Simpson and S.N. Chillrud. “Laboratory investigations of enhanced sulfate reduction as a groundwater arsenic remediation strategy.” Environ. Sci. Tech 41: 6718-6724, 2007.


Trace Metals Core Laboratory

Hall M, Gamble M, Slavkovich V, Liu X, Levy D, Cheng Z, van Geen A, Yunus M, Rahman M, Pilsner JR, Graziano J. “Determinants of arsenic metabolism: blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal-newborn pairs.” Environ Health Perspect 2007;115(10):1503-9.

Gamble MV, Liu X, Slavkovich V, Pilsner JR, Ilievski V, Factor-Litvak P, Levy D, Alam S, Islam M, Parvez F, Ahsan H, Graziano JH. “Folic acid supplementation lowers blood arsenic.” Am J Clin Nutr 2007;86(4):1202-9.


Hydrogeology Core

Alexander, P, Loose, B, and Stute, M. (2007) “A portable membrane-based gas sampler for gases Dissolved in Groundwater”, Eos Trans. AGU, 88(52), Fall Meet. Suppl., Abstract H11C-0680.


2005/2006 Publications

2006 Annual Project and Core Updates (pdf)

Project 1: Genotoxic and Cell Signaling Pathways of Arsenic in Mammalian cells

Ivanov, V.N., , and Hei, T.K., “Dual treatment with COX-2 inhibitor and sodium arsenite leads to induction of surface Fas Ligand expression and Fas-Ligand-mediated apoptosis in human melanoma cells.” Exp. Cell Research 312: 1401-1417, 2006.

Ivanov, V.N., Ze’ev, R., and Hei, T.K., “Opposite roles of FAP-1 and dynamin in the regulation of Fas (CD95) translocation to the cell surface and susceptibility to Fas ligand-mediated apoptosis.” J. Biol. Chem. 281: 1840-1852, 2006.

Ivanov, V. N. and Hei, T.K., “Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and down-regulation of cFLIP expression.” Exp. Cell Research 2006 Dec 10; 312(20); 4120-38. Epub 2006 Sep 28 .


Project 2: Health Effects of Arsenic Cohort Study

Ahsan, H., Y. Chen, et al. (2006). “Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh: baseline results from the Health Effects of Arsenic Longitudinal Study.” Am J Epidemiol 163(12): 1138-48.

Argos , M., M. G. Kibriya, et al. (2006). “Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population.” Cancer Epidemiol Biomarkers Prev 15(7): 1367-75.

Chen, Y., P. Factor-Litvak, et al. (2006). “Nutritional influence on risk of high blood pressure in Bangladesh: a population-based cross-sectional study.”Am J Clin Nutr 84(5): 1224-32.

Chen, Y., J. H. Graziano, et al. (2006). “Modification of risk of arsenic-induced skin lesions by sunlight exposure, smoking, and occupational exposures in Bangladesh.” Epidemiology 17(4): 459-67.

Chen Y, Hakim ME, Parvez F, Islam T, Rahman AM, and Ahsan H. “Arsenic exposure from drinking water and carotid artery intima-media thickness in healthy young adults in Bangladesh.” J Health Pop Res 2006; 24(2): 000-000.

Hafeman, D., H. Ahsan, et al. (2006). “Betel quid: Its tremor-producing effects in residents of Araihazar, Bangladesh.” Mov Disord 21(4): 567-71.

Hall, M., Y. Chen, et al. (2006). “Blood arsenic as a biomarker of arsenic exposure: results from a prospective study.” Toxicology 225(2-3): 225-33.

Parvez, F., Y. Chen, et al. (2006). “Prevalence of arsenic exposure from drinking water and awareness of its health risks in a Bangladeshi population: results from a large population based study.” Environ Health Perspect 114(3): 355-9.


Project 3: Consequences of Arsenic and Manganese Exposure on Childhood Intelligence

Wasserman, GA, Liu, X, Parvez, F, Ahsan, H, Levy, D, Factor-Litvak, P, Kline, J, van Geen, A, Slavkovich, V, LoIacono, NJ, Cheng, Z, Zheng, Y, Graziano, JH: “Water manganese exposure and children’s intellectual function in Araihazar, Bangladesh.” Environ Health Perspect 114: 124-129, 2006a.


Project 4: One-carbon Metabolism, Oxidative Stress and Arsenic Toxicity

Gamble MV, Ahsan H, Slavkovich V, Liu X, Parvez F, Hussain I, Momotaj H, and Graziano JH. “Folate and cobalamin deficiencies and hyperhomocysteinemia in Bangladesh.” Am J Clin Nutr 2005; 81(6):1372-1377.

Gamble MV and Liu X. Letter of Correspondence re: Barr et al., “Urinary creatinine concentrations in the u.s. Population: implications for urinary biologic monitoring measurements.” Env Health Perspect 2005; 113:A442.

Gamble MV, Liu X, Ahsan H, Pilsner JR, Ilievski V, Slavkovic V, Parvez F, Levy D, Factor-Litvak P, Graziano J. “Folate, homocysteine and arsenic metabolism in Bangladesh.” Env Health Perspect 2005; 113(12):1683-1688.

Gamble, MV, Liu X, Ahsan H, Pilsner JR, Ilievski V, Slavkovich V, Parvez F, Chen Y, Levy D, Factor-Litvak P, Graziano JH. “Folate and Arsenic Metabolism: A double-blind placebo controlled folic acid supplementation trial in Bangladesh.” Am J Clin Nutr 2006; 84:1093-1101.


Project 5: Mobilization of Natural Arsenic in Groundwater (formerly Arsenic mobilization in Bangladesh Groundwater)

Datta S., Mailloux B., Hoque M. A., Jung H.-B., Stute M., Ahmed K. M., and Zheng Y. (submitted) “Enrichment of Arsenic in Sediments from the Meghna River Bank in Bangladesh: Implication for Recycling of Arsenic.” Proc Natl Acad Sci U S A.

Jung H. B. and Zheng Y. (2006) “Enhanced recovery of arsenite sorbed onto synthetic oxides by l-ascorbic acid addition to phosphate solution: calibrating a sequential leaching method for the speciation analysis of arsenic in natural samples.” Water Research 40(11), 2168.

Yu G.-Q., Sun D.-J., and Zheng Y. (2006) “Health Effect of Exposure to Natural Arsenic from Groundwater and Coal in China: An Overview of Occurrence.” Environ Health Perspect doi:10.1289/ehp.9268 available via http://dx.doi.org/ [Online 9 January 2007].

Zheng Y. (2007) “The heterogeneity of arsenic in the crust: A linkage to occurrence in Groundwater. Quaternary Sciences (Chinese) 27(1).


Project 7: Mitigation of Arsenic Mobilization in Groundwater

Ahmed, M.F., S. Ahuja, M. Alauddin, S. J. Hug, J.R. Lloyd, A. Pfaff, T. Pichler, C. Saltikov, M. Stute, and A. van Geen, “Ensuring safe drinking water in Bangladesh.” Science (Policy Forum), December 2006.

Ahsan, H., A., Y. Chen, F. Parvez, L. Zablotska, M. Argos, A.Z.M. Iftikhar Hussain, H. Momotaj, D. Levy, Z. Cheng, V. Slavkovich, A. van Geen, G.R. Howe, J.H Graziano, “Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh: Baseline results from the Health Effects of Arsenic Longitudinal Study (HEALS).” Am J Epidemiol, available on-line on April 19, 2006; doi: doi:10.1093/aje/kwj154.

Ahsan H, Chen Y, Parvez F, Argos M, Hussain AI, Momotaj H, Levy D, Van Geen A, Geoffrey HA, Graziano J, “Health Effects of Arsenic Longitudinal Study (HEALS): Description of a multidisciplinary epidemiologic investigation.” J. Exposure Science and Environmental Epidemiology 16, 191-205, 2006.

Chen, Y., M. Hall, J. H. Graziano, V. Slavkovich, A.van Geen, F. Parvez, and H. Ahsan, A prospective study of blood selenium levels and the risk of arsenic-related premalignant skin lesions.” Cancer Epidemiol Biomarkers Prev, November 2006.

Chen, Y., J. H. Graziano, F. Parvez, I. Hussain, H. Momotaj, A. van Geen, G. R. Howe, H. Ahsan, “Modification of risk of arsenic-induced skin lesions by sunlight exposure, smoking, and occupational exposures in Bangladesh.” Epidemiology 17, 459-467, 2006.

Cheng, Z., A. van Geen, A. A. Seddique, and K.M. Ahmed, Response to comments on “Limited temporal variability of arsenic concentration in 20 wells monitored for 3 years in Araihazar, Bangladesh.” Environmental Science and Technology, 40, 1718-1720, 2006.

Hall, M., Y. Chen, H. Ahsan, V. Slavkovich, A. van Geen, F. Parvez and J. Graziano, “Blood arsenic as a biomarker of arsenic exposure: results from a prospective study.” Toxicology, available online 18 June 2006.

Parvez F, Chen Y, Argos M, Hussain AZMI, Momotaj H, Dhar R, van Geen A, Graziano JH, Ahsan H, “Prevalence of arsenic exposure from drinking water and awareness of its health risks in a Bangladeshi population: Results from a large population-based study.” Environ Health Perspect 114, 355-359, 2006.

van Geen, A., M. Trevisani, J. Immel, Md. Jakariya, N. Osman, Z. Cheng, A. Gelman, and K.M. Ahmed, “Targeting low-arsenic groundwater with mobile-phone technology in Araihazar.” J. Health Population and Nutrition, March 2006.

van Geen, A., Y. Zheng, Z. Cheng, H. Yi, R. Dhar, J. M. Garnier, J. Rose, A. A. Seddique, M. A. Hoque, and K.M. Ahmed, “Impact of irrigation with groundwater elevated in arsenic on rice paddies in Bangladesh.” Science of the Total Environment, 367, 769-777, 2006.

van Geen, A., Y. Zheng, Z. Cheng, Z. Aziz, A. Horneman, R. K. Dhar, B. Mailloux, M. Stute, B. Weinman, S. Goodbred, A. A. Seddique, M. A. Hoque, and K. M. Ahmed, “A transect of groundwater and sediment properties in Araihazar, Bangladesh: Further evidence of decoupling between As and Fe mobilization.” Chemical Geology 228, 85-96, 2006.

Wasserman, G. A., X. Liu, F. Parvez, H. Ahsan, D. Levy, P. Factor-Litvak, J. Kline, A. van Geen, V. Slavkovich, N.. J. LoIacono, Z. Cheng, Y. Zheng, J. H. Graziano, “Water manganese exposure and children’s intellectual function in Araihazar, Bangladesh.” Environ Health Perspect, 114, 124-129, 2006.


Research Translation Core: Collaborating with Government & the Public: As & Mn Exposure via Groundwater

Ahmed, M. F., et al. “Ensuring Safe Drinking Water in Bangladesh.” Science 314: 1687-1688, 15 December 2006.

Parisio, S., A.R. Keimowitz, H.J. Simpson, A. Lent, and V. Blackman. “Arsenic-rich iron floc deposits in seeps downgradient of solid waste landfills.”Soil & Sediment Contamination 15: 443-453, 2006.

Zaks, David. “Text messaging for Safe Water.” Published online 27 October 2006. http://www.worldchanging.com/archives/005170.html (reader comments included).
Link to the application: http://www.ldeo.columbia.edu/res/pi/welltracker/

 

 

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